polidocanol and Scalp-Dermatoses

Itch management can be particularly complicated in some small areas like the scalp or the anogenital region for many reasons: the frequently poor diagnosis of the causes of itch in these areas, the dense innervation of these areas, and the symbolic value of these areas for the human psyche. The diagnosis of itchy scalp is easier than that of anogenital pruritus. Clinical examination and a careful inventory of all diseases of the patient and of the local environment are necessary. Localized treatments are frequently used at both sites, whereas specific pharmaceutical formulations are necessary for the pilose or the mucous environment. Nonetheless, systemic treatments or psychological interventions can be very useful.

Topics: Antifungal Agents; Candidiasis; Carcinoma in Situ; Dermatitis, Seborrheic; Female; Genital Diseases, Male; Hemorrhoids; Humans; Keratolytic Agents; Lichenoid Eruptions; Male; Polidocanol; Polyethylene Glycols; Pruritus; Pruritus Ani; Pruritus Vulvae; Psoriasis; Scabies; Scalp Dermatoses

Dry, itchy and inflamed scalp conditions are common and often associated with diseases such as atopic dermatitis or psoriasis. To improve these symptoms, we investigated the efficacy of a new tonic containing the active ingredients urea, lactate, polidocanol, and Glycyrrhiza inflata root extract, containing licochalcone A.. 30 subjects with dry and itchy scalp conditions underwent a randomized half-head study for 4 weeks, applying the leave-on tonic three times a week on one side of the scalp. Tonic effects on skin hydration, itching, lipids, microinflammation, and substantivity of tonic compounds were determined using corneometry, middle-infrared spectroscopy, direct analysis in real-time mass spectrometry, and enzyme-linked immunosorbent assay. Volunteers performed a self-assessment; changes in scalp condition were documented by in vivo microscopy.. After tonic treatment, scalp moisture was significantly increased, whereas scalp itching and tautness were significantly reduced. Results also demonstrated a high substantivity of urea and lactate on the scalp, an increase in triglyceride, and a decrease in free fatty acid levels. The amount of total lipids was unchanged. Analyses of scalp wash-ups verified a significant reduction in important pro-inflammatory markers.. Due to the actives urea, lactate, polidocanol, and the anti-inflammatory licochalcone A, the new scalp tonic exhibited excellent performance in alleviating scalp dryness, itching, microinflammation, and in normalizing disturbances of scalp lipids.

Topics: Chalcones; Cytokines; Glycyrrhiza; Humans; Lactic Acid; Lipid Metabolism; Plant Extracts; Plant Roots; Polidocanol; Polyethylene Glycols; Pruritus; Scalp; Scalp Dermatoses; Urea

Topics: Adult; Cellulitis; Humans; Male; Middle Aged; Polidocanol; Scalp Dermatoses; Sclerosing Solutions; Sclerotherapy; Skin Diseases, Genetic; Sodium Tetradecyl Sulfate

Topics: Adult; Angiolymphoid Hyperplasia with Eosinophilia; Female; Humans; Polidocanol; Polyethylene Glycols; Scalp Dermatoses; Sclerosing Solutions; Sclerotherapy

Topics: Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Hair Dyes; Humans; Hydroquinones; Middle Aged; Patch Tests; Polidocanol; Polyethylene Glycols; Scalp Dermatoses

Topics: Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Hair Preparations; Humans; Middle Aged; Patch Tests; Polidocanol; Polyethylene Glycols; Scalp Dermatoses