polidocanol and Polycystic-Kidney-Diseases

Polycystic kidney disease (PKD) is a common genetic disorder that results in a proliferating and enlarging cyst and ultimately leads to loss of kidney function. Because an enlarged cyst is a primary factor for limited kidney function, the large cyst is surgically removed by laparoscopic deroofing or sclerosant. This a relatively nascent treatment method entails complications and sometimes fail due to the cyst fluid refilling and infection. This study proposes using a more stable and effective polidocanol foam with glycerol and Rose Bengal (GRP form) to prevent cyst regeneration and irritation, which is caused by the required body movement during the treatment. Specifically, the foam retention time and viscosity were increased by adding glycerol up to 10% (w/v). The GRP form inhibited cellular proliferation and disrupted cellular junctions, e-cadherin, and cyst formation, demonstrated by the LDH, Live and Dead, and re-plating culture assays. The GRP foam was shown to be a safe and effective treatment as a commercial grade polidocanol foam form by an in vivo study in which subcutaneously injected mice injected with commercial 3% polidocanol, and the GRP foam showed no difference in inflammation. Thus, this study provides an advanced polidocanol form by adding glycerol and Rose-Bengal to help existing sclerotherapy.

Topics: Animals; Biocompatible Materials; Dogs; Glycerol; Madin Darby Canine Kidney Cells; Male; Mice, Inbred BALB C; Polidocanol; Polycystic Kidney Diseases; Rose Bengal; Sclerosing Solutions

Topics: Aged; Female; Humans; Kidney Diseases, Cystic; Male; Middle Aged; Polidocanol; Polycystic Kidney Diseases; Polyethylene Glycols; Radiography; Sclerosing Solutions

A report is given on the medicinal sclerosing of renal cysts by percutaneous treatment of 15 patients of the age of about 50 to 70 years. By intracaval injection of Aethoxysklerol in a solution of 2% the vessels of the cysts wall are obliterated and the tissue is sclerosed. The described technique avoids incorrect application as well as complications and major strain for the patients. True recurrences are obviously seldom. The report indicates that any evidence of a tumour disease apart from the cysts must bei excluded. The successful treatment shows that the percutaneous sclerosing represents a recommendable alternative to surgical operations. The efficacy and compatibility of the sclerosing agent Aethoxysklerol are particularly mentioned.

Topics: Aged; Follow-Up Studies; Humans; Kidney Diseases, Cystic; Middle Aged; Nephrostomy, Percutaneous; Polidocanol; Polycystic Kidney Diseases; Polyethylene Glycols; Sclerosing Solutions; Ultrasonography