polidocanol and Esophagitis

For a duration of three years, endoscopic hemostasis was carried out in the Department for Gastroenterology at the State Hospital of the Canton of St. Gall on 20 patients suffering from acute upper gastrointestinal hemorrhage. 13 cases were of the hemorrhage type Forest IA, seven cases of the type Forest IB. By way of injecting adrenalin and/or Polidocanol, in all cases an initial hemostasis and in 80% of the cases a definite effect was attained. We judge the injection-method to be a simple, effective and inexpensive way of stopping hemorrhage. This method helps to avoid operating on high-risk patients to stop hemorrhage in the upper gastrointestinal parts.

Topics: Adult; Aged; Aged, 80 and over; Esophagitis; Female; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Polidocanol; Polyethylene Glycols; Sclerosing Solutions

The sclerosing effect of injections of ethoxysklerol, phenol-almondoil, and 10% NaCl-solution into the esophageal walls of 64 wistar-rats was histologically investigated after 2 days, 1 week, 3 weeks, and 4 months. Inflammatory reaction and subsequent sclerosis were of the same kind with all substances. Nevertheless ethoxysklerol showed a slight dependence on concentration. Injection of phenol-almondoil resulted in a less diffuse inflammation than the aqueous solutions. But after 4 months all cases exhibited the same patchy sclerosis despite of the solution used. Our findings and those of the literature allow the conclusion that the sclerosing effect is less dependent from the inflammation-inducing substance itself but from its concentration and localization.

Topics: Animals; Collagen; Dose-Response Relationship, Drug; Esophagitis; Esophagus; Male; Necrosis; Phenols; Plant Oils; Polidocanol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Sclerosing Solutions