podophyllin and Warts

30% of people with anogenital warts (AGW) have spontaneous regression of lesions but there is no way to determine whether a specific lesion will remain. There are a wide range of options available for treating people with AGW and selection is based on clinician's experience, patient preferences and adverse effects. The imiquimod could offer the advantages of patient-applied therapies without incurring the limitations of provider-administered treatments.. To assess the effectiveness and safety of imiquimod for the treatment of AGW in non-immunocompromised adults.. We searched the Cochrane Sexually Transmitted Infections Group Specialized Register (15 April 2014), CENTRAL (1991 to 15 April 2014), MEDLINE (1946 to 15 April 2014), EMBASE (1947 to 15 April 2014), LILACS (1982 to 15 April 2014), World Health Organization International Clinical Trials Registry (ICTRP) (15 April 2014), ClinicalTrials.gov (15 April 2014), Web of Science (2001 to 15 April 2014) and OpenGrey (15 April 2014). We also handsearched conference proceedings, contacted trial authors and reviewed the reference lists of retrieved studies.. Randomized controlled trials (RCTs) comparing the use of imiquimod with placebo, any other patient-applied or any other provider-administered treatment (excluding interferon and 5-fluorouracil which are assessed in other Cochrane Reviews) for the treatment of AGW in non-immunocompromised adults.. Three review authors independently assessed trials for inclusion, extracted data and assessed risk of bias. We resolved any disagreements through consensus. The quality of the evidence was assessed using the GRADE approach.. Ten RCTs (1734 participants) met our inclusion criteria of which six were funded by industry. We judged the risk of bias of the included trials as high. Six trials (1294 participants) compared the use of imiquimod versus placebo. There was very low quality evidence that imiquimod was superior to placebo in achieving complete and partial regression (RR 4.03, 95% CI 2.03 to 7.99; RR 2.56, 95% CI 2.05 to 3.20, respectively). When compared with placebo, the effects of imiquimod on recurrence (RR 2.76, 95% CI 0.70 to 10.91), appearance of new warts (RR 0.76, 95% CI 0.58 to 1.00) and frequency of systemic adverse reactions (RR 0.91, 95% CI 0.63 to 1.32) were imprecise. We downgraded the quality of evidence to low or very low. There was low quality evidence that imiquimod led to more local adverse reactions (RR 1.73, 95% CI 1.18 to 2.53) and pain (RR 11.84, 95% CI 3.36 to 41.63).Two trials (105 participants) compared the use of imiquimod versus any other patient-applied treatment (podophyllotoxin and podophyllin). The estimated effects of imiquimod on complete regression (RR 1.09, 95% CI 0.80 to 1.48), partial regression (RR 0.77, 95% CI 0.40 to 1.47), recurrence (RR 0.49, 95% CI 0.21 to 1.11) or the presence of local adverse reactions (RR 1.24, 95% CI 1.00 to 1.54) were imprecise (very low quality evidence). There was low quality evidence that systemic adverse reactions were less frequent with imiquimod (RR 0.30, 95% CI 0.09 to 0.98).Finally, two trials (335 participants) compared imiquimod with any other provider-administered treatment (ablative methods and cryotherapy). There was very low quality of evidence that imiquimod did not have a lower frequency of complete regression (RR 0.84, 95% CI 0.56 to 1.28). There was very low quality evidence that imiquimod led to a lower rate of recurrence during six-month follow-up (RR 0.24, 95% CI 0.10 to 0.56) but this did not translate in to a lower recurrence from six to 12 months (RR 0.71, 95% CI 0.40 to 1.25; very low quality evidence). There was very low quality evidence that imiquimod was associated with less pain (RR 0.30, 95% CI 0.17 to 0.54) and fewer local reactions (RR 0.55, 95% CI 0.40 to 0.74).. The benefits and harms of imiquimod compared with placebo should be regarded with caution due to the risk of bias, imprecision and inconsistency for many of the outcomes we assessed in this Cochrane Review. The evidence for many of the outcomes that show imiquimod and patient-applied treatment (podophyllotoxin or podophyllin) confer similar benefits but fewer systematic reactions with the Imiquimod, is of low or very low quality. The quality of evidence for the outcomes assessing imiquimod and other provider-administered treatment were of very low quality.

Topics: Adult; Aminoquinolines; Anus Diseases; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Imiquimod; Immunocompetence; Interferon Inducers; Keratolytic Agents; Male; Podophyllin; Podophyllotoxin; Randomized Controlled Trials as Topic; Recurrence; Self Administration; Warts

Although cutaneous warts are one of the most common skin conditions affecting children, their management can be challenging, especially in complex cases and even more so during a single emergency department encounter. Anogenital warts require particular attention because of their possible but nonspecific association with sexual abuse. This review will focus on cutaneous warts and anogenital warts, with a discussion of their recognition and treatment, especially in the emergency department. The medicolegal implications of anogenital warts in children are also reviewed.

Topics: Adolescent; Child; Child Abuse, Sexual; Condylomata Acuminata; Cryotherapy; Diagnosis, Differential; Emergency Service, Hospital; Female; Humans; Keratolytic Agents; Medicine, Traditional; Papillomavirus Infections; Papillomavirus Vaccines; Pediatrics; Podophyllin; Salicylic Acid; Skin Diseases; Uterine Cervical Neoplasms; Warts

Human papillomaviruses (HPV) are found in most human epithelia and some tumors. Most HPV strains associated with cutaneous lesions belong to three types, named alpha, beta and gamma. Although the causal link between genital human papillomavirus infection and cervical neoplasia is well established, the role of beta-HPV in non melanoma skin cancers is unclear. HPV mainly causes benign cutaneous lesions on the hands and soles. Genital HPV infection is the most common sexually transmitted infection. It is generally asymptomatic. The genitals can be infected by two low-risk HPV types (6 and 11), which are responsible for benign anogenital warts (condylomata acuminata). The implications of anogenital warts in children are highly controversial as regards sexual abuse. Treatments (chemical, physical or immunological) are lengthy, expensive, inconvenient and often painful. Recurrence is frequent because of HPV persistence in perilesional skin.

Topics: Adult; Child; Condylomata Acuminata; Cryotherapy; Curettage; Female; Humans; Infant, Newborn; Keratolytic Agents; Male; Middle Aged; Papillomavirus Infections; Penile Diseases; Podophyllin; Recurrence; Time Factors; Uterine Cervical Diseases; Warts

Warts and molluscum contagiosum are common skin diseases in children and are usually self-limiting. The decision of whether to treat children with molluscum or warts should be individualized to the patient and his or her family. Considerations include how symptomatic the lesions are, the extent and duration of disease, the ability of the child and the parents to tolerate and comply with treatment recommendations, and any underlying medical conditions (Table, see page 219). Recurrences of molluscum contagiosum and especially warts are common, and realistic expectations regarding the potential for treatment failure and recurrence should be discussed with the child and his or her family prior to initiating any therapy. As pediatric practitioners, we all remain acutely aware of our patients' physical and psychological development and the potential for any intervention to influence this development. Although various treatment modalities now exist for the treatment of these viral diseases, any intervention should be balanced against these considerations.

Topics: Adhesives; Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Cantharidin; Child; Cimetidine; Cryotherapy; Curettage; Fluorouracil; Hot Temperature; Humans; Imiquimod; Immunotherapy; Irritants; Keratolytic Agents; Laser Therapy; Molluscum Contagiosum; Occlusive Dressings; Pediatrics; Podophyllin; Salicylic Acid; Tretinoin; Warts

The therapeutic approaches to the five common skin problems described range from standard topical and systemic agents to newly introduced alternative medications and techniques. In acne, the type of lesion found on physical examination determines the severity of the disease and its subsequent treatment. When necessary, appropriate precautions must be taken before and during therapy. Fortunately, with the drugs available today, only the most extreme cases of acne should progress to the stage where physical and/or psychological scarring occurs. The number of therapeutic approaches to psoriasis, from steroids to UV light, pays testament to the difficulty in treating this cyclic disease. Until an effective and safe medication is developed, research is sure to continue. Sources of the antigen causing contact dermatitis are sometimes unusual, but the lesions have a characteristic appearance. Several topical and systemic agents are available. Patient education and prophylactic measures play an important role. Therapies for both venereal and nonvenereal warts are proliferating. The evolving understanding of viral oncogenesis in both types of warts promises that this will be an area of continued intense research in the next few years.

Topics: Acne Vulgaris; Adrenal Cortex Hormones; Condylomata Acuminata; Cryosurgery; Dermatitis, Contact; Dermatologic Agents; Humans; Keratolytic Agents; Photochemotherapy; Podophyllin; Psoriasis; Retinoids; Ultraviolet Therapy; Warts

Topics: Antiviral Agents; Bleomycin; Condylomata Acuminata; Cryosurgery; Dinitrofluorobenzene; Electrocoagulation; Female; Fluorouracil; Formaldehyde; Genital Diseases, Female; Genital Diseases, Male; Genital Neoplasms, Female; Genital Neoplasms, Male; Humans; Immunotherapy; Laser Therapy; Male; Podophyllin; Salicylates; Warts

Topics: Antiviral Agents; Bleomycin; Cryosurgery; Fluorouracil; Formaldehyde; Humans; Interferons; Papillomaviridae; Podophyllin; Psychotherapy; Retinoids; Salicylates; Salicylic Acid; Tumor Virus Infections; Warts; Wounds and Injuries

Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial.. To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts.. This study included 57 patients, divided randomly into two groups. Group (A): diphenylcyclopropenone (. Higher clearance was achieved in group A, with 19 of 29 (65.5%) patients, than in group B, with 9 of 28 (32.1%) (. Diphenylcyclopropenone shows a higher success rate than podophyllin in treating genital warts and a lower recurrence rate.

Topics: Condylomata Acuminata; Cyclopropanes; Humans; Podophyllin; Warts

Topics: Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Penile Diseases; Podophyllin; Podophyllotoxin; Random Allocation; Recurrence; Warts

One hundred and sixty five heterosexual men and women with genital warts were treated with inosine pranobex (Imunovir) or conventional treatment, or both. Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts of a shorter duration. Supplementation of conventional treatment with inosine pranobex increased the success rate from 41% to 94%. Immunological studies in 134 patients with genital warts showed an increased number of B cells in 21% of peripheral blood samples. Absence of major defects among circulating lymphocytes suggested that patients with genital warts may have a local immune reaction.

Topics: Adjuvants, Immunologic; Adult; Clinical Trials as Topic; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Inosine; Inosine Pranobex; Male; Podophyllin; Prospective Studies; Random Allocation; Warts

Seventy-three patients with anogenital warts were randomly allocated to a double-blind comparison of treatment with trichloracetic acid (50%) and podophyllin (25%) versus podophyllin (25%) alone. There was no significant difference in the resolution of warts in the two treatment groups among patients followed for three months. Of patients free of warts at six weeks, treatment with trichloracetic acid/podophyllin required significantly fewer applications (mean 2.9) compared with podophyllin alone (mean 4.0). Five (17%) patients in the former group reported side effects but none in the latter group.

Topics: Anus Diseases; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Genital Diseases, Male; Humans; Male; Podophyllin; Trichloroacetic Acid; Warts

One hundred and forty male patients with ano-genital warts were randomly allocated to a double-blind study of 10% and 25% podophyllin in tincture of benzoin compound. One hundred and nine patients attended for a three-month period of surveillance. Only 24 (22%) patients were free of warts after having podophyllin treatment alone, 12 each after treatment with 10% and 25% podophyllin. There was no significant difference in the number of applications needed with each treatment. Neither hypersensitivity nor chemical ulceration occurred.

Topics: Anus Diseases; Clinical Trials as Topic; Double-Blind Method; Genital Diseases, Male; Humans; Male; Podophyllin; Random Allocation; Warts

Topics: Adolescent; Adult; Antibodies; Bromine; Child; Child, Preschool; Clinical Trials as Topic; Foot Diseases; Humans; Immunoglobulin G; Lactates; Podophyllin; Quaternary Ammonium Compounds; Salicylates; Warts

The purpose of this study is to investigate disease trend of genital wart through changes in each treatment method over the past 10 years in Korea.. From 2010 to 2019, surgical treatment including cauterization, excision, cryotherapy, and laser therapy, non-surgical treatment such as podophyllin, and surgical treatment for anorectal lesion were extracted and analyzed from 2010 to 2019. For each treatment method, characteristics such as sex, age, region, medical cost and average number of procedures were analyzed.. The number of patients following all treatment modalities increased every year. Surgical treatment of genital wart and anorectal wart showed a significant increase in male patients. Number of non-surgical treatment decreased in males but increased in females. Surgical removal of the anorectal wart increased more than 250% in over 10 years, and males underwent surgery 4 times more than females. In both surgery and non-surgery, the mean session was higher in males. Most of them were carried out in primary medical institutions. In Seoul and Gyeonggi-do, the largest number of patients received treatment regardless of treatment method.. Treatment for genital warts has increased rapidly over the past 10 years, and the increase in males is remarkable. The main treatment was surgery, and males mainly received surgical treatment, and females mainly received drug treatment. The primary medical institution was in charge of the most treatment. As the number of patients and related medical expenses are increasing rapidly, more attention and response to diseases are needed.

Topics: Condylomata Acuminata; Delivery of Health Care; Female; Humans; Male; Podophyllin; Republic of Korea; Warts

A role of human papilloma virus (HPV) vaccines as a therapy for genital warts was suggested, nevertheless; it has not been established in clinical trials and has yet to be determined. The objective of this study is to evaluate a potential benefit of intralesional injection of bivalent HPV (Cervarix) vaccine as a treatment for anogenital warts versus topical podophyllin resin 25%. Forty-four patients with anogenital warts were included in the study, 22 patients received intralesional Cervarix every 2 weeks until clearance of lesions or for a maximum of five sessions. The other 22 patients received topical podophyllin resin 25% twice weekly until complete resolution or for a maximum of 4 weeks. Follow up was done for 6 months. Dermatology life quality index (DLQI) was measured. Complete clearance of warts was achieved in 10 patients (45.5%) in Cervarix group versus six patients (27.3%) in Podophyllin group. The difference was statistically insignificant. No recurrence of warts was reported in Cervarix group while two patients (33.3%) showed recurrence in Podophyllin group. Both treatments were well tolerated. All patients reported significant improvement of their DLQI. Intralesional Cervarix is a promising modality showing higher rates of complete response, high safety, and no recurrence.

Topics: Condylomata Acuminata; Humans; Injections, Intralesional; Papillomavirus Infections; Papillomavirus Vaccines; Pilot Projects; Podophyllin; Warts

BACKGROUND Plantar warts are benign skin tumors caused by the human papillomavirus (HPV). There are multiple treatments, but none ensure absolute success. Successful treatment depends on several factors, such as the location, number of lesions, HPV biotype, and the patient's health condition. This report presents a 53-year-old woman who had multiple recalcitrant plantar warts with HPV biotype 27 that were treated using a cantharidin-podophyllin-salicylic acid (CPS) formulation after 2 failed treatments. CASE REPORT A 53-year-old woman was seen on October 25, 2021. She had 6 plantar warts due to HPV biotype 27, which was confirmed by polymerase chain reaction using a sample of hyperkeratosis scales obtained from the wart after debridement. Five cryotherapy sessions were applied, without clinical improvement. Two sessions of nitric-acid-zinc complex were then applied, from which the patient reported severe pain, without clinical improvement. Finally, 3 sessions of CPS formulation were applied, and the HPV remitted in all warts. CONCLUSIONS Conservative treatments, such as cryotherapy, have not been effective in a case of multiple recalcitrant plantar warts. The combined action of the 3 compounds of CPS formulation was key in the resolution of this case. Plantar wart treatment should be easy to apply, effective, fast, and efficient. In cases of recalcitrant or numerous warts, treatment should be more aggressive from the beginning if the patient's lifestyle allows it. It would be interesting to conduct randomized clinical trials to find out which patients could be indicated for the CPS formulation as a first line of treatment.

Topics: Alphapapillomavirus; Cantharidin; Female; Humans; Middle Aged; Papillomaviridae; Papillomavirus Infections; Podophyllin; Salicylic Acid; Treatment Outcome; Warts

Topics: Administration, Cutaneous; Condylomata Acuminata; Humans; Podophyllin; Salicylic Acid; Warts

Patients often request treatment of their burdensome cutaneous warts. However, a safe and effective treatment for cutaneous warts is lacking. This study evaluates treatment outcome, side effects, and patient satisfaction after topical application of cantharidin 1% podophyllin 2% salicylic acid 30% (CPS1) solution in a large series of children and adults with cutaneous warts. Fifty-two children and 83 adults with warts, treated with CPS1 solution between October 2012 and October 2014, were included. Complete clearance of warts occurred in 86.5% of children and 62.7% of adults treated with CPS1 solution (p < .01). Resolution of warts was partial in 3.9 and 24.1% and absent in 9.6 and 13.2% of children and adults respectively. Side effects were present in 41.2% of children and 46.3% of adults (p = .7). Most common side effects were blistering, pain, and burning sensation. No serious adverse events occurred. On a 10-point scale, median patient satisfaction score was 9.0 (interquartile range 7.8-10.0) and 8.0 (interquartile range 5.1-9.7) for children and adults respectively (p < .01). CPS1 solution is a safe and promising treatment modality with a high clearance and high patient satisfaction rate for the management of cutaneous warts, particularly in children.

Topics: Administration, Cutaneous; Adult; Age Factors; Cantharidin; Child; Cohort Studies; Female; Humans; Keratolytic Agents; Male; Patient Satisfaction; Podophyllin; Retrospective Studies; Salicylic Acid; Treatment Outcome; Warts

A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent mitotic figures in the basal and suprabasal layers of the epidermis and apoptotic keratinocytes. Histopathologically Bowen's disease was suspected, but was discounted after clinicopathological correlation was obtained and showed absence of epidermal atypia or disorganization. This case demonstrates the histological resemblance of podophyllin reaction to Bowen's disease. Differentiation of self-inflicted from organic skin disease may be difficult, especially where histopathological findings are confounded by cutaneous application of toxins.

Topics: Adult; Bowen's Disease; Caustics; Delusions; Diagnosis, Differential; Female; Humans; Parakeratosis; Podophyllin; Scalp Dermatoses; Self Medication; Skin Neoplasms; Warts

A 57-year-old depressive and alcohol-dependent man was admitted because of frequent nausea and vomiting and abdominal complaints after he had ingested 40 ml of a tincture for treating warts. He was under the influence of alcohol, but normally oriented and without contributory findings other than his gastrointestinal complaints and tachypnea.. Transaminases were raised (GOT 1197 U/l, GPT 170 U/l, gammaGT 150 U/l, LDH 2047 U/l), as were creatine phosphokinase (426 U/l) and ferritin (12 200 ng/ml). Platelet count was 36000 mm3, Leucocytes count 11 700/mm (3). Gastroscopy showed marked mucosal necrosis along the entire esophagus and the pulled-up small intestine (state after gastrectomy).. The patient became comatose within 5 hours, acidotic, oliguric, required ventilation and went into severe shock. The symptoms and the fact that podophyllin (pod.) was the main agent in the wart preparation confirmed the suspicion of pod. poisoning. Symptomatic and intensive care measures stabilized his critically grave condition. He was extubated on the 7th day after ingestion and on the 10th day was discharged at his own request in a relatively good general state. When he was re-admitted after 4 weeks he was without psychiatric symptoms but deeply depressed, and he had signs of a polyneuropathy in all limbs, typical of pod. toxin poisoning.. Pod. toxin, a spindle poison, is the toxic agent of pod., the resin from the roots and rhizomes of various Berberis plants. While the potential toxicity of the resin, taken either orally or applied externally, has been long known, the poorly definied raw product is still being added to anti-wart tinctures.

Topics: Administration, Oral; Alcoholism; Coma; Depression; Esophagus; Hospitalization; Humans; Keratolytic Agents; Male; Middle Aged; Platelet Count; Podophyllin; Podophyllotoxin; Polyneuropathies; Warts

Human papilloma virus (HPV)-related cutaneous manifestations occur with increased frequency and severity among HIV-infected persons. In this report, we describe an HIV-infected man with persistent, severe cutaneous hand warts that did not respond to multiple therapies, including liquid nitrogen cryotherapy, topical dinitrochlorobenzene, topical podophyllin, and intralesional interferon-alfa injections. Approximately 1 year after starting a potent protease inhibitor-containing antiretroviral regimen, the patient's recalcitrant cutaneous warts markedly diminished in size, even though the patient did not receive any specific therapy for the warts after starting aggressive antiretroviral therapy. The patient continued on a potent protease inhibitor-containing antiretroviral regimen and, approximately 2 years later, the warts completely resolved. Our patient's dramatic clinical improvement of cutaneous HPV infection that followed protease inhibitor-containing antiretroviral therapy provides a clear-cut example that protease inhibitor-containing combination antiretroviral therapy can produce significant clinical benefit.

Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cryosurgery; Dinitrochlorobenzene; Hand Dermatoses; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Interferon-alpha; Keratolytic Agents; Male; Papillomaviridae; Papillomavirus Infections; Podophyllin; Treatment Outcome; Tumor Virus Infections; Warts

Topics: Child; Female; Foot Diseases; Humans; Injections, Intradermal; Podophyllin; Warts

In Northern Ireland in 1984 anogenital warts were diagnosed in 592 (352 male, 240 female) genitourinary medicine clinic attenders. Of these patients, 561 were heterosexual, 28 homosexual and three male bisexual. In the male patients 290 had penile warts, 67 meatal warts, 59 perianal warts, 25 anal canal warts and five rectal warts. In the female patients, 193 had vulval warts, 27 vaginal warts, 25 cervical warts, 107 perianal warts, 30 anal canal warts and one a rectal wart. Sexual partners were brought to the clinic by 345 patients and of these 93 male and 100 female partners had genital warts.The mean time from exposure to development of warts was 17 weeks SE +/- 1.5 (range 1 week - 12 months). As treatment, podophyllin 25% was used alone in 218 patients, and 132 were known to have had clearance of warts. At least one other sexually transmissible infection was found in 407 (69%) of patients. Cervical smears were taken in 164 women and were abnormal in 40 (24%). Cervical cytology was recorded in 89 regular sexual partners of male patients and was abnormal in 23 (26%).

Topics: Female; Humans; Male; Northern Ireland; Papillomaviridae; Podophyllin; Sexually Transmitted Diseases; Tumor Virus Infections; Vaginal Smears; Warts

Topics: Administration, Topical; Genitalia; Humans; Podophyllin; Warts

572 patients with solitary or multiple genital warts attending the Department of Genitourinary Medicine at the Royal Victoria Hospital, Bournemouth, U.K. between January 1981 and December 1981 were allocated to either podophyllin or cryotherapy for the treatment of their warts. Of 350 patients successfully treated for their warts and returned for a follow-up examination 6 weeks or more after completing their treatment, 206 (139 men and 67 women) were treated with podophyllin, and 144 (86 men and 58 women) with cryotherapy. One hundred five (51%) of those treated with podophyllin and 114 (79%) treated with cryotherapy were free of warts at their follow-up examination. Patients treated with podophyllin required a mean of 6.7 +/- SD 3.5 treatments over a mean of 4.7 +/- SD 2.4 weeks, whereas those receiving cryotherapy required a mean of 2.6 +/- SD 2.0 applications over a mean of 2.3 +/- SD 1.2 weeks.

Topics: Cryosurgery; Female; Follow-Up Studies; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Podophyllin; Warts

Topics: Anus Diseases; Drug Therapy, Combination; Humans; Podophyllin; Trichloroacetic Acid; Warts

One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%. One hundred patients or their families were reached 6 months to 1 year later. This treatment was effective in 81 cases.

Topics: Adolescent; Cantharidin; Child; Child, Preschool; Combined Modality Therapy; Debridement; Drug Therapy, Combination; Foot; Humans; Podophyllin; Salicylates; Salicylic Acid; Skin Diseases; Warts

Topics: Administration, Topical; Adult; Benzalkonium Compounds; Bleomycin; Child; Cryotherapy; Formaldehyde; Glutaral; Humans; Nitrogen; Podophyllin; Salicylates; Skin Diseases; Warts

Topics: Cautery; Cresols; Curettage; Dermatologic Agents; Foot Dermatoses; Hand Dermatoses; Humans; Keratolytic Agents; Ointments; Podophyllin; Trichloroacetic Acid; Warts

Topics: Adult; Child; Cryosurgery; Female; Formaldehyde; Humans; Male; Podophyllin; Salicylates; Salicylic Acid; Warts

Topics: Female; Fluorouracil; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Podophyllin; Warts

Topics: 1-Propanol; Humans; Immunity, Cellular; Immunoglobulin G; Papillomaviridae; Podophyllin; Salicylates; Warts

The authors describe a patient who developed delirium secondary to the topical absorption of podophyllin; this may be the first known case of delirium after topical application of the drug. Other serious medical and neurological complications of podophyllin poisoning are also discussed.

Topics: Administration, Topical; Adult; Delirium; Female; Humans; Podophyllin; Psychoses, Substance-Induced; Sexually Transmitted Diseases; Warts

Topics: Administration, Topical; Adolescent; Adult; Child; Electrocoagulation; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Male; Middle Aged; Ointments; Podophyllin; Vitamin A; Warts

A delineation of the medical problems associated with anal sexual eroticism has been presented. Our method of approach to both the patient and the various disease states has been described. Treatment of the most commonly encountered condition, condyloma acuminata, has been detailed. Precautionary measures to be taken and possible diagnostic pitfalls have been mentioned.

Topics: Anal Canal; Anus Diseases; Anus Neoplasms; Condylomata Acuminata; Enterobacteriaceae; Female; Foreign Bodies; Gonorrhea; Humans; Male; Podophyllin; Rectal Diseases; Sexual Behavior; Syndrome; Syphilis; Ulcer; Urinary Fistula; Warts

A total of 56 cases with warts in which podophyllin treatment was either contraindicated or a failure, were treated with nitrous oxide using a Keymed 500 cryosurgical appliance. Forty-three patients who completed treatment were followed-up for three months. Thirty-seven of these had received applications of podophyllin twice weekly for an average period of three months before cryosurgery. The remaining cases in whom podophyllin was considered to be contraindicated included five with vulval warts (two were pregnant, two were bronchial asthmatics taking oral prednisolone, and one was taking oral clomiphene citrate), and a diabetic patients with penile warts. Thirty-two were cured and 11 relapsed. The latter were re-treated at the end of the follow-up period with two freezing cycles of 45 seconds at an interval of 30 minutes. Seven were cured and the remaining four men who failed to respond belonged to the podophyllin-resistant group and included three with metal warts and one homosexual with anogenital warts. Cryosurgery gave a cumulative success rate of 91%. A single freezing cycle was free from complications but a double freezing cycle was often followed by severe local reaction.

Topics: Cryosurgery; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Podophyllin; Warts

Topics: Anus Neoplasms; Condylomata Acuminata; Formaldehyde; Genitalia; Humans; Immunotherapy; Nitrogen; Podophyllin; Salicylates; Skin Diseases, Infectious; Warts

Warts are common skin lesions caused by a papova virus. Their clinical appearance is variable. There is no definitive therapy. Therapy must be individually modified to get the best result with the least discomfort to the patient. Most warts will spontaneously resolve after an average of two years, so any therapy that has serious side effects or results in scarring should not be used. New modes of therapy, particularly immunotherapy, look promising but are still in the experimental stage.

Topics: Adolescent; Adult; Child; Child, Preschool; Cryosurgery; Humans; Nitrates; Nitrogen; Papillomaviridae; Phenols; Podophyllin; Polyomaviridae; Psychotherapy; Salicylates; Silver Nitrate; Trichloroacetic Acid; Warts

Topics: Condylomata Acuminata; Female; Genital Diseases, Female; Herpes Simplex; Humans; Male; Penile Diseases; Podophyllin; Sexually Transmitted Diseases; Uterine Cervical Neoplasms; Warts

Topics: Female; Genital Diseases, Female; Humans; Podophyllin; Pregnancy; Pregnancy Complications, Infectious; Vulva; Warts

Topics: Adolescent; Blood Pressure; Cyanosis; Diplopia; Female; Fetal Death; Humans; Paresthesia; Podophyllin; Potassium; Pregnancy; Pregnancy Complications; Uterine Diseases; Vomiting; Vulva; Warts

Topics: Adult; Darier Disease; Female; Humans; Leg Dermatoses; Nevus; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Warts

Topics: Antineoplastic Agents; Fluorouracil; Gels; Humans; Methotrexate; Occlusive Dressings; Podophyllin; Vinblastine; Warts

Topics: Adolescent; Cautery; Child; England; Family Practice; General Practice; Humans; Podophyllin; Podophyllum; Salicylates; Silver Nitrate; Statistics as Topic; Trichloroacetic Acid; Warts

Topics: Child; Dry Ice; Formaldehyde; Humans; Minor Surgical Procedures; Nitrogen; Ointments; Podophyllin; Podophyllum; Resorcinols; Salicylic Acid; Silver Nitrate; Trichloroacetic Acid; Warts

Topics: Lactates; Podophyllin; Podophyllum; Salicylic Acid; Trichloroacetic Acid; Warts

Topics: Cough; Morphine; Podophyllin; Podophyllum; Poisoning; Pregnancy; Toxicology; Warts

Topics: Humans; Papilloma; Podophyllin; Podophyllum; Warts

Topics: Animals; Condylomata Acuminata; Disease; Humans; Military Personnel; Podophyllin; Podophyllum; Thoracica; Warts

Topics: Anal Canal; Anus Diseases; Condylomata Acuminata; Disease; Genitalia; Humans; Podophyllin; Warts

Topics: Condylomata Acuminata; Humans; Podophyllin; Poisoning; Warts

Topics: Animals; Foot Diseases; Humans; Podophyllin; Thoracica; Warts

Topics: Animals; Condylomata Acuminata; Humans; Male; Penile Diseases; Penis; Podophyllin; Thoracica; Warts

Topics: Animals; Foot Diseases; Humans; Podophyllin; Thoracica; Warts

Topics: Condylomata Acuminata; Humans; Podophyllin; Warts

Topics: Animals; Foot; Foot Diseases; Humans; Podophyllin; Thoracica; Warts

Topics: Foot Diseases; Humans; Podophyllin; Podophyllum; Warts

Topics: Colchicine; Condylomata Acuminata; Humans; Podophyllin; Warts

Topics: Condylomata Acuminata; Humans; Podophyllin; Podophyllum; Resins, Plant; Warts

Topics: Adenoma; Humans; Neoplasms; Podophyllin; Podophyllum; Warts

Topics: Condylomata Acuminata; Humans; Podophyllin; Warts