podophyllin and Vulvar-Diseases

The incidence of human papillomavirus infection is increasing. More than 60 types of human papillomavirus have been isolated; some types are known to have malignant potential. Differential diagnosis of the lesions includes condyloma latum, seborrheic keratoses, nevi, pearly penile papules and neoplasms. The goal in treating noncervical human papillomavirus infection is the elimination of lesions; eradication of the virus is not yet possible. Current forms of treatment include cryotherapy, podophyllum resin, podophilox, trichloroacetic acid, laser ablation, loop electrosurgical excision procedure (LEEP), fluorouracil and alpha interferon. Success in treating condyloma may be increased if the area is first soaked with 5 percent acetic acid to more clearly show the extent of the local infection. Recurrence is a problem no matter what form of therapy is used.

Topics: Condylomata Acuminata; Cryosurgery; Diagnosis, Differential; Electrocoagulation; Female; Fluorouracil; Humans; Injections, Intralesional; Interferon-alpha; Laser Therapy; Male; Papillomaviridae; Penile Diseases; Podophyllin; Trichloroacetic Acid; Vulvar Diseases

Zinc sulfate is beneficial in the treatment of epithelial warts. We conducted this study to compare the efficacy of combination therapy of oral zinc sulfate with conventional treatments in the treatment of vulvar warts.. This study was a randomized controlled trial. The sample size was 42 in each group. Women aged 20-50 years were placed by the block randomized method into six groups: the podophyllin-, imiquimod- and cryotherapy-treated groups, and another three groups receiving 8-week combination therapy of 400 mg oral zinc sulfate with one of the above-mentioned treatments. Data were analyzed using anova and Fischer's exact test with spss16.. A total of 228 patients were recruited and completed the study in six treatment groups. No significant difference was observed in the response to treatment among these groups. Relapse after 6 months was significantly higher in the podophyllin-, imiquimod- and cryotherapy-treated patients compared to patients receiving these treatments in combination with oral zinc sulfate (P<0.05).. Combined therapy of oral zinc sulfate with conventional treatments of vulvar warts appears to reduce the relapse rate.

Topics: Administration, Cutaneous; Administration, Oral; Adult; Aminoquinolines; Astringents; Combined Modality Therapy; Condylomata Acuminata; Cryosurgery; Female; Humans; Imiquimod; Interferon Inducers; Iran; Keratolytic Agents; Middle Aged; Patient Dropouts; Podophyllin; Secondary Prevention; Skin Cream; Vulvar Diseases; Young Adult; Zinc Sulfate

Topics: Condylomata Acuminata; Female; Humans; Infant; Keratolytic Agents; Podophyllin; Vulvar Diseases

Topics: Abscess; Bartholin's Glands; Condylomata Acuminata; Cryosurgery; Cysts; Electrosurgery; Female; Fluorouracil; Humans; Immunotherapy; Laser Therapy; Podophyllin; Testosterone; Vulva; Vulvar Diseases; Vulvar Neoplasms

Topics: Adult; Carcinoma, Squamous Cell; Condylomata Acuminata; Female; Humans; Neoplasm Metastasis; Podophyllin; Precancerous Conditions; Vulvar Diseases; Vulvar Neoplasms

Topics: Condylomata Acuminata; Disease; Female; Humans; Podophyllin; Podophyllum; Pregnancy; Pregnancy Complications; Vulva; Vulvar Diseases

Topics: Condylomata Acuminata; Disease; Female; Humans; Podophyllin; Vulva; Vulvar Diseases; Vulvar Neoplasms