podophyllin and Uterine-Cervical-Neoplasms

Although cutaneous warts are one of the most common skin conditions affecting children, their management can be challenging, especially in complex cases and even more so during a single emergency department encounter. Anogenital warts require particular attention because of their possible but nonspecific association with sexual abuse. This review will focus on cutaneous warts and anogenital warts, with a discussion of their recognition and treatment, especially in the emergency department. The medicolegal implications of anogenital warts in children are also reviewed.

Topics: Adolescent; Child; Child Abuse, Sexual; Condylomata Acuminata; Cryotherapy; Diagnosis, Differential; Emergency Service, Hospital; Female; Humans; Keratolytic Agents; Medicine, Traditional; Papillomavirus Infections; Papillomavirus Vaccines; Pediatrics; Podophyllin; Salicylic Acid; Skin Diseases; Uterine Cervical Neoplasms; Warts

The main goal of the therapy of human papillomavirus (HPV) infection is the management of the virus. There is no cure for HPV infections. The treatment goal for the female patient is to destroy lesions that are malignant or premalignant. The male patient is treated because he is a carrier of HPV who can infect previously uninfected women and possibly reinfect an already treated partner with a potentially oncogenic virus. Various treatment modalities are discussed.

Topics: Condylomata Acuminata; Cryosurgery; Female; Fluorouracil; Humans; Laser Therapy; Male; Papillomaviridae; Podophyllin; Trichloroacetic Acid; Tumor Virus Infections; Uterine Cervical Neoplasms

Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Drug Resistance; Drug Therapy; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lymphatic System; Mechlorethamine; Methotrexate; Mitomycins; Podophyllin; Preoperative Care; Thiotepa; Triaziquone; Uterine Cervical Neoplasms; Vinblastine

This article describes an approach to the evaluation and treatment of condyloma acuminatum (anogenital warts) that is based on the results of new clinical research on the biology of the human papillomavirus. A more extensive diagnostic protocol, including routine cervicovaginal examination and Papanicolaou smear, is proposed for female patients because of the close association of genital human papillomavirus infections with cervical carcinoma. Two highly effective therapies, cryosurgery and carbon dioxide laser photocoagulation, are described and compared with older regimens. Recent developments in immunotherapy for resistant condyloma acuminatum are also discussed.

Topics: Clinical Trials as Topic; Condylomata Acuminata; Cryosurgery; Electrocoagulation; Female; Fluorouracil; Genital Neoplasms, Female; Genital Neoplasms, Male; Humans; Immunotherapy; Interferons; Laser Therapy; Male; Ointments; Papanicolaou Test; Podophyllin; Urethral Neoplasms; Uterine Cervical Neoplasms; Vaginal Neoplasms; Vaginal Smears

A prospective study was performed for a new model concerning the potentiation of radiation with Podophyllum (Proresid) and the radioprotection with Acethylhomocystein-thiolactone (Reducdyn) in cases of the squamous cell carcinoma of the uterine cervix. The study was carried out on the basis of alternated data of birth. The total number of the randomization was 256, consisting of 173 stages II und 83 stages III. All patients were irradiated with 6000 mgeh Ra and 4500 R 60Co. In addition to the irradiation one group of 128 patients received an infusion of 1g Podophyllum/day after irradiation. Another group of 46 patients was treated prior to irradiation with 1g Acethyl-homocystein-thiolactone (AHCT) and with Podophyllum after exposure. The total dosage was between 30 and 50g Pod. and 30 and 50g AHCT. It could be shown that the survival rate after three years was increased up to 15%. An earlier study revealed a five-year-survival rate of 23%.

Topics: Female; Homocysteine; Humans; Methods; Podophyllin; Prospective Studies; Uterine Cervical Neoplasms

Topics: Antineoplastic Agents; Clinical Trials as Topic; Cobalt Isotopes; Female; Follow-Up Studies; Humans; Mouth Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Radiotherapy Dosage; Uterine Cervical Neoplasms; Vaginal Smears; Vitamin K

Topics: Condylomata Acuminata; Female; Genital Diseases, Female; Herpes Simplex; Humans; Male; Penile Diseases; Podophyllin; Sexually Transmitted Diseases; Uterine Cervical Neoplasms; Warts

Topics: Animals; Carcinoma in Situ; Cervix Uteri; Drug Interactions; Epithelium; Estradiol; Female; Haplorhini; Methylcholanthrene; Mice; Podophyllin; Progesterone; Uterine Cervical Diseases; Uterine Cervical Neoplasms

Topics: Cell Division; Cobalt Radioisotopes; Female; Humans; Methods; Podophyllin; Radioisotope Teletherapy; Uterine Cervical Neoplasms

Topics: Aftercare; Alkaloids; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Bone Neoplasms; Breast Neoplasms; Colchicine; Cyclophosphamide; Female; Genital Neoplasms, Female; Hormones; Humans; Neoplasm Metastasis; Ovarian Neoplasms; Peptide Hydrolases; Peptides; Pleurisy; Podophyllin; Uterine Cervical Neoplasms; Uterine Neoplasms; Vinblastine

Topics: Antineoplastic Agents; Cyclophosphamide; Female; Genital Neoplasms, Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Ovarian Neoplasms; Perchlorates; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Tryptophan; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Animals; Antineoplastic Agents; Benzopyrenes; Carcinoma, Squamous Cell; Cervix Uteri; Female; Mice; Neoplasms, Experimental; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Uterine Cervical Neoplasms

Topics: Antineoplastic Agents; Choriocarcinoma; Cytostatic Agents; Female; Humans; Podophyllin; Podophyllum; Uterine Cervical Neoplasms; Uterine Neoplasms; Vaginal Neoplasms

Topics: Animals; Cervix Uteri; Female; Humans; Mice; Neoplasms, Experimental; Podophyllin; Podophyllum; Uterine Cervical Neoplasms

Topics: Cervix Uteri; Female; Humans; Podophyllin; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

Topics: Carcinoma in Situ; Female; Humans; Hyperplasia; Podophyllin; Podophyllum; Uterine Cervical Neoplasms