podophyllin and Skin-Neoplasms

A 9-year-old black girl with vertically acquired human immunodeficiency virus (HIV) and no history of condyloma acuminata presented with a 4-year history of enlarging and spreading dark brown flat papules in the perineum. Some of the lesions were confluent and extended from the clitoris to the labia majora and posteriorly to the buttocks and perianal region. A biopsy of one of the lesions showed bowenoid features. Our patient had a normal Pap smear, but vaginal and cervical biopsy specimens revealed human papillomavirus type 16. Therapy with topical imiquimod cream every other day was started, but little improvement was noted after 2 months. Application of 25% podophyllin every 4 to 8 weeks was added, and improvement was noted within 1 month. After 1 year of treatment, the patient had complete resolution of all lesions, and she has had no further appearance of lesions. Our case emphasizes the need for increased awareness of the potential for development of bowenoid papulosis in HIV-positive children as well as the successful treatment of our patient with topical therapy alone.

Topics: Acquired Immunodeficiency Syndrome; Adult; Aminoquinolines; Antineoplastic Agents, Phytogenic; Bowen's Disease; Child; Female; Humans; Imiquimod; Infectious Disease Transmission, Vertical; Maternal-Fetal Exchange; Papillomaviridae; Papillomavirus Infections; Perineum; Podophyllin; Pregnancy; Pregnancy Complications, Infectious; Remission Induction; Skin Neoplasms; Tumor Virus Infections; Vulvar Neoplasms

Topics: Antimetabolites; Antineoplastic Agents; Carcinoma, Basal Cell; Fluorouracil; Folic Acid Antagonists; Humans; Keratosis; Methotrexate; Mycosis Fungoides; Nitrogen Mustard Compounds; Ointments; Podophyllin; Precancerous Conditions; Skin Diseases; Skin Neoplasms; Virus Diseases

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease; relatively mild XP patients are sometimes designated as having pigmented xerodermoid or xerodermoid pigmentosum (XP-V), a variant of XP. It is commonly associated with many long-standing skin conditions and tumors, including malignancies, management of which is necessary to prevent the progress of the disease. The objective of the study was to report the use of a number of innovative therapeutic and prophylactic treatments, beyond surgery, such as topical 5-fluorouracil, topical imiquimod, other topical immunomodulators, or photodynamic therapy, in treating skin eruptions and their complications in XP patients. This was a prospective therapeutic interventional study in which 50 patients with XP-V were evaluated. Age of subjects ranged from 2 to 50 years with a mean age of 18 years. This study was divided into two parts. In part one, patients were treated by applying topical zinc sulfate 25% twice daily on entire face for 2 months, then once daily for several months or years. In another instance, two women were treated with heat dermabrasion with needle diathermy on the entire face under local anesthesia, followed by application of trichloroacetic acid 35% peeling in a single session. In part two, topical podophyllin 25% was used as therapy for 18 patients, all of whom had XP complications, such as keratoacanthoma, basal cell carcinomas and squamous cell cancers.

Topics: Adolescent; Adult; Child; Child, Preschool; Dermabrasion; Female; Hot Temperature; Humans; Keratosis, Actinic; Melanosis; Middle Aged; Podophyllin; Skin Neoplasms; Trichloroacetic Acid; Xeroderma Pigmentosum; Young Adult; Zinc Sulfate

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease; relatively mild XP patients are sometimes designated as having pigmented xerodermoid or xerodermoid pigmentosum (XP-V), a variant of XP. It is commonly associated with many long-standing skin conditions and tumors, including malignancies, management of which is necessary to prevent the progress of the disease. The objective of the study was to evaluate an innovative therapeutic treatment, beyond surgery, surgical excision, cryotherapy, electrocautery and curettage, or Mohs surgery, for the management of skin tumors in XP.This was a prospective therapeutic interventional study comprising 50 patients with XP-V. Age of subjects ranged from 2 to 50 years, with a mean age of 18 years. Several measures were evaluated in part one of this study, and a number of others (as reviewed in part one) were successful in prophylaxis of skin tumors in XP as well as in treating earlier stigmata of XP; however, these measures were notably less successful in treating well-developed skin tumors in XP patients, and 18 of the 50 patients evaluated in part one had well-developed tumors (total 22 lesions) refractory to treatments. Podophyllin 25% in 100-mL tincture of benzoin was applied topically to lesions until complete resolution was documented in 18 patients with XP complications, such as keratoacanthoma (KA), basal cell carcinoma, or squamous cell carcinoma. Topical podophyllin 25% in benzoin was a less destructive alternative treatment for skin cancer and KA in XP patients.

Topics: Adolescent; Adult; Benzoin; Carcinoma, Basal Cell; Child; Child, Preschool; DNA Repair; Humans; Keratoacanthoma; Middle Aged; Podophyllin; Skin Neoplasms; Xeroderma Pigmentosum; Young Adult

A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent mitotic figures in the basal and suprabasal layers of the epidermis and apoptotic keratinocytes. Histopathologically Bowen's disease was suspected, but was discounted after clinicopathological correlation was obtained and showed absence of epidermal atypia or disorganization. This case demonstrates the histological resemblance of podophyllin reaction to Bowen's disease. Differentiation of self-inflicted from organic skin disease may be difficult, especially where histopathological findings are confounded by cutaneous application of toxins.

Topics: Adult; Bowen's Disease; Caustics; Delusions; Diagnosis, Differential; Female; Humans; Parakeratosis; Podophyllin; Scalp Dermatoses; Self Medication; Skin Neoplasms; Warts

To check the clinical, histological, evolutionary and therapeutic characteristics of Bowen's Disease.. A descriptive study of a crossover type.. Primary Care and a Dermatology clinic at a Health Centre.. There were 4 adult males, aged between 25 and 31, with pigmented papulosis lesions on their external genitals. Two of them were HIV-positive.. Clinical records were used. The diagnosis was confirmed through histological analysis. In all cases the lesions were papulosis, multiple and affecting the external genitals. The patients were clinically controlled until the lesions disappeared. The patients' sexual partners were referred to Gynaecology clinics for examination, but no pathology was found in any of them.. Basic knowledge of Bowen's Disease in Primary Care is important given that it is essential to reach a diagnosis as early as possible, in order to monitor the patient and his partner and so avoid any future complications arising from the pathology's presence, such as tumour processes affecting the uterine cervix. The performance of histological analyses when faced with any suspicious genital lesion must be encouraged, given that this technique is non-aggressive.

Topics: Adult; Bowen's Disease; Electrocoagulation; HIV Seropositivity; Humans; Male; Penile Neoplasms; Podophyllin; Skin Neoplasms

This article deals with surgical as well as with conservative treatment of condylomata acuminata, e.g. 10% podophyllin in liquid paraffin. Both methods are equally successful and may be combined in special cases.

Topics: Combined Modality Therapy; Condylomata Acuminata; Humans; Neoplasm Recurrence, Local; Podophyllin; Skin Neoplasms

The effects of resin of podophyllin on lesions of condyloma acuminatum have posed problems to pathologists who sought to differentiate them histologically from squamous cell carcinoma in situ. The most striking histologic changes in lesions of condyloma acuminatum following application of resin of podophyllin occur within the first 48 hours. They are pallor of the epidermis secondary to both intracellular and intercellular edema, numerous necrotic keratinocytes in the lower half of the epidermis, and a marked increase in the number of mitotic figures there. Within the edematous papillary dermis, there is a scattered infiltrate of lymphocytes, histiocytes, and neutrophils. The absence of nuclear atypia, multinucleated keratinocytes, and dyskeratotic cells, and the presence of the orderly sequence of maturation of keratinocytes within the epidermis permit histologic differentiation of podophyllin-treated condyloma acuminatum from true squamous-cell carcinoma in situ. The acute histologic changes induced by podophyllin begin to wane by 72 hours after the resin has been applied. At this time, necrotic keratinocytes are found mostly within the upper portion of the epidermis and few mitotic figures are seen. By 1 week after application of podophyllin there are virtually no histologic abnormalities within the epidermis.

Topics: Adult; Carcinoma in Situ; Carcinoma, Squamous Cell; Condylomata Acuminata; Diagnosis, Differential; Humans; Podophyllin; Resins, Plant; Skin Neoplasms

Topics: Condylomata Acuminata; Humans; Neoplasm Recurrence, Local; Podophyllin; Skin Neoplasms

Topics: Adult; Female; Hemangioma; Humans; Male; Podophyllin; Skin Neoplasms; Vulvar Neoplasms

Topics: Condylomata Acuminata; Humans; Podophyllin; Skin Neoplasms

Topics: Aged; Antineoplastic Agents; Humans; Male; Melanoma; Neoplasm Metastasis; Podophyllin; Skin Neoplasms

Topics: Humans; Leukemia, Monocytic, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Podophyllin; Scalp; Skin Neoplasms

Topics: Colchicine; Diagnosis, Differential; Fluorouracil; Humans; Keratoacanthoma; Podophyllin; Skin Diseases; Skin Neoplasms

Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Fluorouracil; Humans; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Skin Neoplasms

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Fluorouracil; Humans; Methotrexate; Podophyllin; Skin Neoplasms; Triaziquone; Zinc

Topics: Buschke-Lowenstein Tumor; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Genitalia, Male; Humans; Lymphatic Metastasis; Male; Neoplasms; Papilloma; Pathology; Penile Neoplasms; Podophyllin; Podophyllum; Scrotum; Skin Neoplasms; Surgical Procedures, Operative

Topics: Humans; Nevus; Nevus, Pigmented; Occlusive Dressings; Ointments; Podophyllin; Podophyllum; Skin Neoplasms

Topics: Podophyllin; Podophyllum; Research Design; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Cell- and Tissue-Based Therapy; Humans; Podophyllin; Skin Neoplasms

Topics: Humans; Podophyllin; Skin Neoplasms

Topics: Humans; Neoplasms; Podophyllin; Skin; Skin Neoplasms

Topics: Humans; Podophyllin; Radiotherapy; Radium; Skin Neoplasms; X-Ray Therapy

Topics: Carcinoma; Carcinoma, Basal Cell; Cell- and Tissue-Based Therapy; Humans; Podophyllin; Skin Neoplasms

Topics: Eyelid Neoplasms; Eyelids; Humans; Podophyllin; Skin; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Cell- and Tissue-Based Therapy; Humans; Podophyllin; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Podophyllin; Skin Neoplasms

Topics: Humans; Neoplasms; Podophyllin; Skin Neoplasms

Topics: Humans; Podophyllin; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Humans; Podophyllin; Podophyllum; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Humans; Neoplasms, Glandular and Epithelial; Podophyllin; Skin Neoplasms

Topics: Carcinoma; Humans; Podophyllin; Skin; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Humans; Podophyllin; Skin; Skin Neoplasms

Topics: Podophyllin; Skin Neoplasms

Topics: Female; Humans; Male; Neoplasms; Papilloma; Podophyllin; Skin Neoplasms; Urethra; Vulva