podophyllin and Penile-Diseases

Human papillomaviruses (HPV) are found in most human epithelia and some tumors. Most HPV strains associated with cutaneous lesions belong to three types, named alpha, beta and gamma. Although the causal link between genital human papillomavirus infection and cervical neoplasia is well established, the role of beta-HPV in non melanoma skin cancers is unclear. HPV mainly causes benign cutaneous lesions on the hands and soles. Genital HPV infection is the most common sexually transmitted infection. It is generally asymptomatic. The genitals can be infected by two low-risk HPV types (6 and 11), which are responsible for benign anogenital warts (condylomata acuminata). The implications of anogenital warts in children are highly controversial as regards sexual abuse. Treatments (chemical, physical or immunological) are lengthy, expensive, inconvenient and often painful. Recurrence is frequent because of HPV persistence in perilesional skin.

Topics: Adult; Child; Condylomata Acuminata; Cryotherapy; Curettage; Female; Humans; Infant, Newborn; Keratolytic Agents; Male; Middle Aged; Papillomavirus Infections; Penile Diseases; Podophyllin; Recurrence; Time Factors; Uterine Cervical Diseases; Warts

Topics: Adult; Aminoquinolines; Condylomata Acuminata; Cryosurgery; Diagnosis, Differential; Drug Administration Schedule; Humans; Imiquimod; Keratolytic Agents; Male; Penile Diseases; Penis; Podophyllin; Podophyllotoxin; Self Administration; Skin Diseases, Papulosquamous; Treatment Outcome; Trichloroacetic Acid

The incidence of human papillomavirus infection is increasing. More than 60 types of human papillomavirus have been isolated; some types are known to have malignant potential. Differential diagnosis of the lesions includes condyloma latum, seborrheic keratoses, nevi, pearly penile papules and neoplasms. The goal in treating noncervical human papillomavirus infection is the elimination of lesions; eradication of the virus is not yet possible. Current forms of treatment include cryotherapy, podophyllum resin, podophilox, trichloroacetic acid, laser ablation, loop electrosurgical excision procedure (LEEP), fluorouracil and alpha interferon. Success in treating condyloma may be increased if the area is first soaked with 5 percent acetic acid to more clearly show the extent of the local infection. Recurrence is a problem no matter what form of therapy is used.

Topics: Condylomata Acuminata; Cryosurgery; Diagnosis, Differential; Electrocoagulation; Female; Fluorouracil; Humans; Injections, Intralesional; Interferon-alpha; Laser Therapy; Male; Papillomaviridae; Penile Diseases; Podophyllin; Trichloroacetic Acid; Vulvar Diseases

The aims of this study were to: 1) ascertain if podophyllin resin in 0.5% [PE(0.5%)] and 0.25% [PE(0.25%)] in ethanol (PE) self-applied sequentially for 3 days with 4 days break cycle is as effective as supervised podophyllin 25% in tincture benzoin (PB) applied in the clinic biweekly in treating penile warts and 2) ascertain if PE causes less skin irritation than PB.. The clearance rate of penile warts was 36.4% (4/11) in PE (0.5%) treated group, 66.7% (4/6) in the PE (0.25%) treated group and 33.3% (6/18) for PB treated group after 1 week (ns). The wart clearance rate at 6 weeks for PE (0.5%) treated group, PE (0.25%) treated group and PB treated group were 81.8% (9/11), 100% (6/6) and 83.3% (15/17) respectively (ns). There were 47 individual warts on the penis of the 17 patients in the PE treated group and 58 individual warts on the penis of the 18 patients in the PB treated group. Based on the response of individual warts to the 2 treatment regimens, the clearance rate was 42.6% (20/47) for the PE treated group and 25% (15/56) for the PB treated group after 1 week treatment (ns). At 6 weeks follow-up, the clearance rate for the PE treated group and the PB treated group were 85.1% (40/47) and 73.2% (41/56) respectively (ns). Skin irritation including superficial erosions, pain and itch were observed in 47% (8/17) in patients treated with PE compared to 38.9% (7/18) in patients treated with PB (ns) during the 6 weeks follow-up period. The clearance rate of patients treated with PE (0.25%) was compared to those treated with PE (0.5%). Four out of six of PE (0.25%) treated patients had clearance of warts after 1 week and 100% clearance at the end of 6 weeks. None experienced any skin irritation.. This study demonstrates that 0.5% podophyllin (and possibly 0.25% podophyllin) in ethanol is effective in eradicating penile warts. It can be used by patients for self-treatment at home with greater convenience and is more cost effective than the conventional podophyllin 25% in tincture benzoin paint.

Topics: Adult; Aged; Condylomata Acuminata; Emollients; Ethanol; Humans; Keratolytic Agents; Male; Middle Aged; Penile Diseases; Plant Extracts; Podophyllin; Solvents; Styrax

To compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and podophyllin 2.0% sourced from Podophyllum emodii.. A prospective double blind randomised study.. 315 patients with penile warts attending two departments of genitourinary medicine.. Absence of warts, cessation of treatment due to severe side effects at 5 weeks.. Of the 315 patients, 244 conformed to the protocol. Analysis was on an intention to treat basis. At 5 weeks no significant differences were found in the extent of healing of warts or in side effects for the three treatment groups. The costs of drug treatment (excluding staff time) are at least pounds 10.00 less for podophyllin than podophyllotoxin. A fourfold variation in the active constituents of the podophyllin preparations did not produce appreciably different clinical responses. In a subanalysis no evidence of deterioration in effectiveness of podophyllin over time was demonstrated.. Penile warts in selected cases can be safely treated with 0.5-2.0% podophyllin self applied by the patient at a fraction of the cost of commercially available podophyllotoxin. The shelf life of the podophyllin extracts is at least 3 months. These findings may be especially relevant in countries where resources for health care are limited.

Topics: Condylomata Acuminata; Double-Blind Method; Drug Stability; Humans; Keratolytic Agents; Male; Penile Diseases; Podophyllin; Podophyllotoxin; Prospective Studies; Self Administration

Topics: Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Penile Diseases; Podophyllin; Podophyllotoxin; Random Allocation; Recurrence; Warts

Topics: Administration, Cutaneous; Administration, Oral; Condylomata Acuminata; Dermatologic Agents; Drug Therapy, Combination; Humans; Isotretinoin; Keratolytic Agents; Male; Penile Diseases; Podophyllin; Recurrence

Topics: Adult; Humans; Male; Penile Diseases; Podophyllin

Topics: Condylomata Acuminata; Female; Genital Diseases, Female; Herpes Simplex; Humans; Male; Penile Diseases; Podophyllin; Sexually Transmitted Diseases; Uterine Cervical Neoplasms; Warts

Topics: Adult; Condylomata Acuminata; Diabetes Mellitus, Type 1; Electrocoagulation; Humans; Male; Oxytetracycline; Penile Diseases; Podophyllin

Topics: Adult; Carcinoma, Squamous Cell; Condylomata Acuminata; Diagnosis, Differential; Humans; Lymph Node Excision; Male; Penile Diseases; Penile Neoplasms; Podophyllin; Precancerous Conditions

Topics: Aluminum; Burns, Chemical; Circumcision, Male; Colchicine; Condylomata Acuminata; Female; Humans; Male; Mucous Membrane; Papilloma; Penile Diseases; Plants, Medicinal; Podophyllin; Syndrome; Urethral Diseases

Topics: Animals; Condylomata Acuminata; Humans; Male; Penile Diseases; Penis; Podophyllin; Thoracica; Warts

Topics: Balanitis; Condylomata Acuminata; Humans; Male; Penile Diseases; Penis; Podophyllin

Topics: Condylomata Acuminata; Humans; Male; Penile Diseases; Penis; Podophyllin