podophyllin and Ovarian-Neoplasms

The authors have analysed the influence exercised by the combined therapy of the ovary carcinoma on the plasma ribonuclease activity in Wistar rats. The medicaments "Proresid", "VM-26", and "Methotrexat" together with a percutaneous irradiation of the abdomen did not alterate perceptibly the enzyme activity during the experiment, but there was a considerable reduction of the enzyme activity after an application of "Endoxan", "Adriblastin" and "Methotrexat" with subsequent administration of "Leukovorin". The most violent ribonuclease suppression, however, was obtained by an intraperitoneal instillation of radiogold and a fractioned percutaneous irradiation of the abdomen with intercalated administration of "Endoxan".

Topics: Animals; Cyclophosphamide; Doxorubicin; Female; Leucovorin; Methotrexate; Ovarian Neoplasms; Podophyllin; Podophyllotoxin; Rats; Ribonucleases

A case report is given of a peritoneal pseudomyxoma originating from pseudomucineous cystadenomata of both ovaries. The diagnosis was established by peritoneoscopy and histological examination. Both ovaries were removed surgically and cytostatic treatment initiated thereafter; hyperthermic peritoneal perfusion was done as well. The patient lives after surgery now for more than a year without recurrence of the disease.

Topics: Ascites; Cystadenoma; Female; Fluorouracil; Humans; Hydrazines; Methotrexate; Middle Aged; Myxoma; Ovarian Neoplasms; Peritoneal Diseases; Podophyllin; Prednisolone

Cells from three carcinomas of the uterine corpus and from 14 ovarian carcinomas have been cultured in vitro by the monlayer and sandwich methods. They were evaluated on the basis of morphological criteria after 24 hours of incubation with 4-hydroperoxicyclophosphamide, amethopterine, mitopodozide and VM-26 Sandoz, using two dose ranges in each case. The index of 3H-thymidine was determined by means of two parallel experiments. Later results concerning pharmacokinetics of the cyclophosphamide have lead us to apply the technique of primary culture. Owing to the long duration of the incubation period, the 4-hydroperoxicyclophosphamide with its secondary and degradation products can influence the greatest possible numbers of cells through several phases of the cell cycle, thus obtaining an approach to in-vivo kinetics. A concentration of substrate per unit of volume, higher than the actually in vivo expected, is to compensate the short half-life of 4-hydroperoxicyclophosphamide as well as the lack of the supply-function of current dynamics. 4-hydroperoxicyclophosphamide was the cytostatic agent with the largest range of effectiveness, followed by amethopterine, while the mitotic poisons mitopodozide and VM-26 Sandoz were less effective. The histology and degree of differentiating of the tumors as well as the proliferation rate are not correlated in a distinct manner with sensitivity to cytostatics. Pretreatment with cytostatics of with irradiation revealed no certain influence upon subsequent sensitivity to cytostatics.

Topics: Adult; Aged; Cell Differentiation; Cell Division; Culture Techniques; Cyclophosphamide; Drug Resistance; Female; Humans; Hydrazines; Methotrexate; Middle Aged; Ovarian Neoplasms; Podophyllin; Podophyllotoxin; Uterine Neoplasms

Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; In Vitro Techniques; Methods; Methotrexate; Neoplasms; Ovarian Neoplasms; Podophyllin; Suspensions; Time Factors; Triaziquone; Tritium; Uridine

Topics: Adolescent; Dysgerminoma; Female; Humans; Neoplasm Metastasis; Ovarian Neoplasms; Podophyllin; Triaziquone

Topics: Carcinoma; Cyclophosphamide; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Leukopenia; Long-Term Care; Methotrexate; Ovarian Neoplasms; Podophyllin; Prognosis

Topics: Cyclophosphamide; Drug Combinations; Female; Humans; Methotrexate; Ovarian Neoplasms; Podophyllin; Radioisotope Teletherapy

Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Female; Genital Neoplasms, Female; Humans; Ovarian Neoplasms; Podophyllin; Sarcoma; Uterine Neoplasms

Topics: Aftercare; Alkaloids; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Bone Neoplasms; Breast Neoplasms; Colchicine; Cyclophosphamide; Female; Genital Neoplasms, Female; Hormones; Humans; Neoplasm Metastasis; Ovarian Neoplasms; Peptide Hydrolases; Peptides; Pleurisy; Podophyllin; Uterine Cervical Neoplasms; Uterine Neoplasms; Vinblastine

Topics: Adult; Cystadenoma; Female; Humans; Ovarian Neoplasms; Peritoneal Neoplasms; Peritonitis; Podophyllin; Pregnancy; Puerperal Disorders

Topics: Adrenalectomy; Aged; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Cortisone; Cyclophosphamide; Drug Synergism; Ethinyl Estradiol; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrazines; Hypophysectomy; Kidney Neoplasms; Lung Neoplasms; Male; Melanoma; Melphalan; Mesothelioma; Methotrexate; Middle Aged; Nandrolone; Neoplasm Metastasis; Ovarian Neoplasms; Podophyllin; Sarcoma; Thiotepa; Vinblastine

Topics: Antineoplastic Agents; Female; Gold Colloid, Radioactive; Humans; Hysterectomy; Injections, Intraperitoneal; Middle Aged; Ovarian Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum

Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Ovarian Neoplasms; Pelvic Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum

Topics: Antineoplastic Agents; Cyclophosphamide; Female; Genital Neoplasms, Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Ovarian Neoplasms; Perchlorates; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Tryptophan; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Adult; Female; Humans; Ovarian Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum

Topics: Antineoplastic Agents; Female; Humans; Neoplasms; Ovarian Neoplasms; Plant Poisoning; Podophyllin; Podophyllum; Resins, Synthetic; Toxicology