podophyllin has been researched along with Neoplasms* in 67 studies
2 review(s) available for podophyllin and Neoplasms
Article | Year |
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[Side-effects of cytostatic therapy with special reference to potential carcinogenic effects].
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Busulfan; Fluorouracil; Hemangiosarcoma; Mercaptopurine; Mitomycins; Neoplasms; Neoplasms, Experimental; Podophyllin; Rats; Sarcoma, Experimental; Thiotepa; Vinblastine | 1971 |
Multiple combination therapy in cancer chemotherapy in Japan.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chloroquine; Cyclophosphamide; Cytarabine; Drug Synergism; Fluorouracil; Humans; Japan; Leukemia; Lymphoma; Mercaptopurine; Mitomycins; Neoplasms; Podophyllin; Prednisolone; Thiotepa; Vincristine; Vitamin K 1 | 1969 |
2 trial(s) available for podophyllin and Neoplasms
Article | Year |
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A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin.
Pre-clinical studies indicate that cisplatin encapsulated in STEALTH((R))liposomes (SPI-77) retains anti-tumour activity, but has a much reduced toxicity, compared to native cisplatin. A phase I study was conducted to determine the toxicity and pharmacokinetics of SPI-77 administered to children with advanced cancer not amenable to other treatment. Paediatric patients were treated at doses ranging from 40 to 320 mg m(-2)by intravenous infusion every 4 weeks. Blood samples taken during, and up to 3 weeks after, administration and plasma and ultrafiltrate were prepared immediately. Urine was collected, when possible, for 3 days after administration. SPI-77 administration was well tolerated with the major toxicity being an infusion reaction which responded to modification of the initial infusion rate of SPI-77. Limited haematological toxicity and no nephrotoxicity were observed. No responses to treatment were seen during the course of this phase I study. Measurement of total plasma platinum showed that cisplatin was retained in the circulation with a half life of up to 134 h, with maximum plasma concentrations approximately 100-fold higher than those reported following comparable doses of cisplatin. Comparison of plasma and whole blood indicated that cisplatin was retained in the liposomes and there was no free platinum measurable in the ultrafiltrate. Urine recovery was less than 4% of the dose administered over 72 h. Results from this phase I study indicate that high doses of liposomal cisplatin can safely be given to patients, but further studies are required to address the issue of reformulation of liposomally bound cisplatin. Topics: Adolescent; Antineoplastic Agents; Area Under Curve; Child; Child, Preschool; Cholesterol; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Infant; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liposomes; Male; Neoplasms; Podophyllin; Podophyllotoxin; Time Factors; Triglycerides | 2001 |
[5-year results of combined treatment with the cobalt bomb and the cytostatic preparation SP-G and SP-I (Sandoz)].
Topics: Antineoplastic Agents; Cobalt Isotopes; Humans; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1965 |
63 other study(ies) available for podophyllin and Neoplasms
Article | Year |
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Cancer morbidity in rheumatoid arthritis patients treated with Proresid or parenteral gold.
The cancer risk was studied by comparison of 305 rheumatoid arthritis (RA) patients exposed to Proresid during a mean time of 22 months and 305 RA patients exposed to sodium aurothiomalate during a mean time of 19 months with the regional cancer register. The mean observation time was 6.9 years (2,117 person-years) for the Proresid-treated and 7.5 years (2,293 person-years) for the gold-treated patients. No increased risk of total malignancies was observed for either group. However, looking at separate tumours, an increased risk of lymphoma and leukemia was found although only significant in the gold-treated group. It was not correlated to dosage or duration of either therapy. The increased risk is consistent with earlier reports of an increased risk of hematopoietic malignancies in RA patients. Marginal over and underreporting, particularly of hematopoietic malignancies, were observed, mainly due to clinicians' failure to report and to recall false reports. Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Gold Sodium Thiomalate; Humans; Infusions, Parenteral; Male; Morbidity; Neoplasms; Podophyllin; Podophyllotoxin; Risk Factors; Sweden | 1995 |
Proresid therapy in rheumatoid arthritis. A comparison with injectable gold using life-table analysis.
Proresid, mainly consisting of podophyllotoxin derivatives and two glycosides thereof, has been used as a disease-modifying antirheumatic drug in Sweden since the late 1960s. A life-table analysis of Proresid treatment averaging 41 months (range 4-144) in 79 rheumatoid arthritis patients showed a termination rate of 40, 56, 75 and 85% after 1/2, 1, 2 and 4 years, respectively. Dominant reasons for discontinuing therapy were inefficacy (37%) and gastrointestinal symptoms (35%). The risk of discontinuation of therapy due to inefficacy was constant over time, while the risk due to other causes, including side effects, gradually decreased. A comparison with injectable gold therapy showed, after adjusting for confounding factors, that the total termination incidence was higher (p < 0.05) in the Proresid-treated patients. A comparison with the regional cancer register of 334 patients exposed to Proresid for a mean time of 2.2 years showed no increased cancer risk after a mean observation time of 6.1 years. Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cohort Studies; Female; Gold; Humans; Incidence; Injections; Life Tables; Male; Middle Aged; Neoplasms; Patient Compliance; Patient Dropouts; Podophyllin; Podophyllotoxin; Prognosis; Risk Factors; Treatment Outcome | 1993 |
Side effects of Proresid in the treatment of chronic arthritis.
Topics: Aged; Amyloidosis; Arthritis; Diarrhea; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Neoplasms; Podophyllin; Podophyllotoxin | 1988 |
Structure-activity relationships of podophyllin congeners that inhibit topoisomerase II.
Various analogs of etoposide have been studied and compared in different tests in order to identify which tests best correlate with antitumor activity. These tests included DNA breakage assays using standard alkaline elution procedures as a means of studying topoisomerase II inhibition in intact cells, cytotoxicity studies in naturally sensitive and resistant human carcinoma cell lines, in vitro assays of the effect of the different congeners on topoisomerase II activity, and a preliminary evaluation of the ability of etoposide and teniposide to induce resistance. As in previous studies, a direct correlation was seen between double strand DNA breakage and cytotoxicity but not between single strand DNA breakage and cytotoxicity. Analogs with blocked 4'-hydroxyl groups were poor antitumor agents but were still capable of inhibiting topoisomerase II as evidenced by the production of DNA breaks. However, this DNA breakage was qualitatively different from that produced by VP16. None of the analogs were able to overcome either naive or acquired drug resistance. The dihydroxy analog of VP16, a possible bioactivated analog, was much less potent and possibly less stable than VP16. A model is proposed for the inhibition of topoisomerase II by demethylepipodophyllotoxins that may explain the relationship between double strand DNA breakage and cytotoxicity. Topics: Cell Line; DNA, Neoplasm; Drug Resistance; Humans; Neoplasms; Podophyllin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1987 |
The diagnostic value of circulating trophoblast-specific beta 1-glycoprotein (TSG) in cancer patients.
Topics: Female; Humans; Hydrazines; Male; Neoplasms; Podophyllin; Podophyllotoxin; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1980 |
[The effects of cytostatic agents on short-term cultures (3H-uridine incorporation) and tissue cultures (cell counts) from human tumors (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; In Vitro Techniques; Methods; Methotrexate; Neoplasms; Ovarian Neoplasms; Podophyllin; Suspensions; Time Factors; Triaziquone; Tritium; Uridine | 1974 |
Clinical investigation of a new podophyllum derivative, epipodophyllotoxin, 4'-demethyl-9-(4,6-O-2-thenylidene- -D-glucopyranoside) (NSC-122819), in patients with malignant lymphomas and solid tumors.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Female; Glycosides; Haplorhini; Hodgkin Disease; Humans; Immunosuppression Therapy; Lactones; Lymphoma; Male; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Rats; Thiophenes | 1972 |
[Studies on the understanding of problems of radiologic cytostatic combination treatment. 6. Further syncytostatic studies with 5-fluorouracil, natulan and proresid].
Topics: Amides; Animals; Antineoplastic Agents; Cyclophosphamide; Ear, External; Female; Fluorouracil; Granulation Tissue; Hydrazines; Mice; Neoplasms; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Radiation Effects; Radiation Injuries, Experimental; Radiotherapy Dosage; Statistics as Topic; Tail; Wound Healing | 1969 |
[Considerations on the use of Proresid (SPI-SPG Sandoz) as an adjuvant in the treatment of tumors (preliminart communication)].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Child; Female; Humans; Male; Middle Aged; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1968 |
[Therapeutic effects of podophyllin derivatives on malignant neoplasms].
Topics: Aged; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1968 |
[Clinical use of podophyllin derivatives SP-I and SP-G in the treatment of cancer].
Topics: Adult; Female; Humans; Male; Middle Aged; Neoplasms; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1968 |
Human anticancer effect of podophyllum derivatives (SPG and SPI): a preliminary report.
Topics: Adult; Deglutition Disorders; Esophageal Neoplasms; Gingiva; Humans; Injections, Intra-Arterial; Male; Mandibular Neoplasms; Mouth; Mouth Neoplasms; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1967 |
SPI and SPG in the treatment of advanced malignant lesions.
Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Hormones; Humans; Leukopenia; Neoplasms; Paralysis; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1967 |
[New possibilities in testing resistance of human carcinoma tissue to cytostatic agents in vivo].
Topics: Animals; Cyclophosphamide; Humans; Methotrexate; Neoplasm Transplantation; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Rats; Thiotepa; Triaziquone | 1967 |
[Clinical experiences with SP-I].
Topics: Humans; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1967 |
[Cytostatic chemotherapy in the treatment of malignant tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Hematopoiesis; Humans; Kidney Neoplasms; Leukopenia; Lung Neoplasms; Lymphatic Diseases; Lymphatic Metastasis; Mediastinal Neoplasms; Neoplasms; Podophyllin; Rectal Neoplasms; Triaziquone | 1966 |
[Submicroscopic changes in human cancer cells under the effect of SP-I and SP-G "Sandoz"].
Topics: Aged; Antineoplastic Agents; Female; Humans; Male; Microscopy, Electron; Middle Aged; Neoplasms; Otorhinolaryngologic Diseases; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1966 |
[Treatment of malignant tumors with SP-I/SP-G Sandoz (Proresid)].
Topics: Adult; Antineoplastic Agents; Female; Humans; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1966 |
GIANT CONDYLOMA AND VERRUCOUS CARCINOMA OF THE GENITAL AREA.
Topics: Buschke-Lowenstein Tumor; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Genitalia, Male; Humans; Lymphatic Metastasis; Male; Neoplasms; Papilloma; Pathology; Penile Neoplasms; Podophyllin; Podophyllum; Scrotum; Skin Neoplasms; Surgical Procedures, Operative | 1965 |
[THE VALUE OF THE ADDITION OF A PODOPHYLLUM TOXIN COMPOUND TO THE SURGICAL AND RADIOLOGICAL TREATMENT OF MAMMARY CARCINOMAS].
Topics: Antineoplastic Agents; Breast Neoplasms; Humans; Neoplasms; Podophyllin; Podophyllum; Toxicology | 1965 |
[LATEST RESEARCH ON ALTERATIONS OF THE MUCOSA AND SKIN OF THE LIP OF THE RAT CAUSED BY PODOPHYLLIN].
Topics: Carcinogens; Lip; Mucous Membrane; Necrosis; Neoplasms; Neoplasms, Experimental; Podophyllin; Podophyllum; Rats; Research; Skin Ulcer; Toxicology | 1965 |
[Cytostatic therapy of metastatic and advanced malignant tumors of the ENT region with podophyllin derivatives (SPI-SPG)].
Topics: Humans; Neoplasms; Otorhinolaryngologic Diseases; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum | 1965 |
FATAL POISONING WITH PODOPHYLLUM RESIN.
Topics: Antineoplastic Agents; Female; Humans; Neoplasms; Ovarian Neoplasms; Plant Poisoning; Podophyllin; Podophyllum; Resins, Synthetic; Toxicology | 1964 |
[ATTEMPTED TREATMENT OF CANCER IN AN ADVANCED STAGE BY PODOPHYLLIN DERIVATIVES].
Topics: Antineoplastic Agents; Drug Therapy; Geriatrics; Neoplasms; Podophyllin; Podophyllum; Toxicology | 1964 |
[ON GENERAL AND LOCAL ANTIMITOTIC THERAPY OF GENITAL CARCINOMA WITH THE PODOPHYLLINIC DERIVATIVES SP-I AND SP-G].
Topics: Antimitotic Agents; Antineoplastic Agents; Carcinoma; Female; Genital Neoplasms, Female; Geriatrics; Humans; Neoplasms; Podophyllin; Podophyllum; Toxicology | 1964 |
[THE DISTRIBUTION OF THE ANTIMITOTIC AGENT, ETHYLHYDRAZIDE OF PODOPHYLLIC ACID (SP-I 77) IN THE BODY AND IN HUMAN MALIGNANT TUMORS].
Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Autoradiography; Carcinoma; Colonic Neoplasms; Dogs; Glioma; Humans; Intestines; Kidney; Liver; Lymph Nodes; Metabolism; Neoplasms; Pharmacology; Podophyllin; Podophyllotoxin; Podophyllum; Tritium | 1964 |
[A SUPPLEMENT TO CANCER OPERATIONS BY PODOPHYLLIN DERIVATIVES].
Topics: Antineoplastic Agents; Dietary Supplements; Humans; Neoplasms; Podophyllin; Podophyllum; Surgical Procedures, Operative | 1964 |
[CHANGES IN LIP MUCOSA AND SKIN OF RATS RECEIVING PODOPHYLLIN].
Topics: Lip; Lip Neoplasms; Mucous Membrane; Neoplasms; Neoplasms, Experimental; Pathology; Pharmacology; Podophyllin; Podophyllum; Rats; Research; Toxicology | 1963 |
[RESULTS OF OUR EXPERIENCE WITH SP-I AND SP-G IN THE TREATMENT OF MALIGNANT NEOPLASMS].
Topics: Antineoplastic Agents; Neoplasms; Podophyllin; Podophyllum; Toxicology | 1963 |
[Possibilities and limitations of additional control of malignant tumors by cytostatics, especially by podophyllin derivatives].
Topics: Cytostatic Agents; Humans; Neoplasms; Podophyllin; Podophyllum; Radiotherapy | 1962 |
[A case of melanocarcinoma of the temporal region improved by podophyllin].
Topics: Face; Facial Neoplasms; Head; Melanoma; Neoplasms; Podophyllin; Podophyllum; Temporal Lobe | 1960 |
Thoughts of a radiologist in a general hospital on cancer of the bladder.
Topics: Hospitals, General; Neoplasms; Podophyllin; Radiology; Radiotherapy; Urinary Bladder Neoplasms | 1959 |
Some biochemical responses of normal and malignant tissues to tumor-necrotizing agents.
Topics: Antineoplastic Agents; Humans; Neoplasms; Podophyllin; Podophyllum | 1959 |
Effects of a podophyllotoxin derivative on tissue culture systems in which human cancer invades normal tissue.
Topics: Antineoplastic Agents; Humans; Neoplasms; Podophyllin; Podophyllotoxin; Research Design; Tissue Culture Techniques | 1957 |
Disposition of biosynthetically labeled C-14 podophyllotoxin in normal and tumor-bearing animals.
Topics: Neoplasms; Personality; Podophyllin; Podophyllotoxin | 1957 |
[Prolongation of the life of tumor-bearing animals following the combined administration of podophyllin and TEM].
Topics: Animals; Combined Modality Therapy; Life; Neoplasms; Neoplasms, Experimental; Podophyllin; Triethylenemelamine | 1957 |
Enzyme changes induced in normal and malignant tissues with chemical agents. VI. Effect of acetylpodophyllotoxin-omega-pyridinium chloride on malic-oxidase and on isocitric-oxidase systems of sarcoma 37.
Topics: Animals; Neoplasms; Oxidoreductases; Podophyllin; Sarcoma; Sarcoma 37 | 1956 |
[Treatment of cancer of the skin with podophyllin].
Topics: Humans; Neoplasms; Podophyllin; Skin; Skin Neoplasms | 1956 |
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
Topics: Adenosine Triphosphatases; Animals; Enzymes; Fructose-Bisphosphate Aldolase; Glucose; Hexokinase; Neoplasms; Nucleotides; Podophyllin; Podophyllotoxin; Pyridines; Sarcoma 37; Sarcoma, Experimental | 1955 |
Enzyme changes induced in normal and malignant tissues with chemical agents. V. Effect of acetylpodophyllotoxin-omega-pyridinium chloride on uricase, adenosine deaminase, nucleoside phosphorylase, and glutamic dehydrogenase activities.
Topics: Adenosine Deaminase; Enzymes; Humans; Neoplasms; Oxidation-Reduction; Pentosyltransferases; Podophyllin; Urate Oxidase | 1955 |
[Results in podophyllotoxin therapy of malignant tumors].
Topics: Humans; Neoplasms; Podophyllin; Podophyllotoxin; Podophyllum | 1955 |
Vascular reactions of normal and malignant tissues in Vivo. VI. The role of hypotension in the action of components of podophyllin on transplanted sarcomas.
Topics: Hypotension; Neoplasm Transplantation; Neoplasms; Podophyllin; Sarcoma | 1954 |
Response of patients with advanced neoplasms to the intravenous administration of alpha-peltatin.
Topics: Administration, Intravenous; Neoplasms; Podophyllin; Podophyllotoxin | 1954 |
The cytological effect of chemicals on ascites sarcomas. I. Partial damage in tumor cells by podophyllin, followed by temporary regression and prolongation of life of tumor-bearing rats.
Topics: Animals; Ascites; Life Support Care; Neoplasms; Podophyllin; Rats; Sarcoma; Sarcoma, Experimental | 1953 |
[Clinical experiences in therapy of malignant tumors with podophyllotoxin].
Topics: Humans; Neoplasms; Podophyllin; Podophyllotoxin | 1953 |
[Anti-neoplastic action of podophyllin].
Topics: Neoplasms; Podophyllin | 1952 |
[Modern trends in chemotherapy of tumors].
Topics: Colchicine; Ethers; Folic Acid Antagonists; Hormones; Humans; Mechlorethamine; Mitosis; Neoplasms; Nitrogen Mustard Compounds; Pentamidine; Podophyllin; Poisons; Steroids; Stilbenes; Urethane | 1952 |
Podophyllin treatment of skin carcinomas.
Topics: Humans; Neoplasms; Podophyllin; Skin Neoplasms | 1952 |
[Podophyllin and its active principles in cancer therapy].
Topics: Humans; Neoplasms; Podophyllin | 1952 |
Preliminary report of lysis of mouse sarcoma 37 by a component isolated from resin of podophyllum.
Topics: Animals; Mice; Neoplasms; Podophyllin; Podophyllum; Resins, Plant; Sarcoma; Sarcoma 37 | 1951 |
Damage induced in sarcoma 37 with podophyllin, podophyllotoxin alpha-peltatin, beta-peltatin, and quercetin.
Topics: Animals; Humans; Neoplasms; Podophyllin; Podophyllotoxin; Quercetin; Sarcoma 37 | 1950 |
Effect of alpha-peltatin, beta-peltatin, podophyllotoxin on lymphomas and other transplanted tumors.
Topics: Humans; Lymphoma; Neoplasm Transplantation; Neoplasms; Podophyllin; Podophyllotoxin | 1950 |
[Action of podophyllin on experimental sarcoma].
Topics: Animals; Humans; Neoplasms; Podophyllin; Sarcoma; Sarcoma, Experimental | 1950 |
The treatment of papillomatosis with podophyllin.
Topics: Humans; Neoplasms; Papilloma; Podophyllin | 1950 |
On some chemotherapeutic experiments with podophyllotoxin.
Topics: Humans; Leukemia; Neoplasms; Podophyllin; Podophyllotoxin | 1950 |
Treatment of juvenile papilloma of the larynx with resin of podophyllum; a preliminary report.
Topics: Adolescent; Humans; Larynx; Neoplasms; Papilloma; Podophyllin; Podophyllum; Resins, Plant | 1950 |
[New treatment of epithelioma, podophyllin therapy (peltacure)].
Topics: Carcinoma; Humans; Neoplasms; Neoplasms, Glandular and Epithelial; Podophyllin; Skin | 1950 |
Studies on the mechanisms of podophyllin action on tumors and normal skin.
Topics: Humans; Neoplasms; Podophyllin; Skin | 1949 |
Effect of podophyllin on transplanted mouse tumors.
Topics: Animals; Mice; Neoplasm Transplantation; Neoplasms; Podophyllin | 1948 |
Effect of podophyllin on tumor cells in tissue culture.
Topics: Humans; Immunologic Tests; Neoplasms; Podophyllin; Research Design | 1947 |
Failure of resin of podophyllum in the treatment of verruca vulgaris.
Topics: Adenoma; Humans; Neoplasms; Podophyllin; Podophyllum; Warts | 1947 |
Podophyllin treatment of soft papillomas of the female urethra.
Topics: Female; Humans; Male; Neoplasms; Papilloma; Podophyllin; Skin Neoplasms; Urethra; Vulva | 1947 |
Effect of podophyllin on transplanted mouse tumors.
Topics: Animals; Mice; Neoplasm Transplantation; Neoplasms; Podophyllin | 1947 |