podophyllin and Enteritis

Using Heglostix-Ames test strips, it was possible with normally fed animals, to furnish evidence of occult blood in spontaneous droppings of mice. The mice were exposed either to partial irradiation encompassing the abdomen and using different exit doses between 100 R and 1100 R, or were injected intramuscularly with doses between 120 and 900 mg/kg Endoxan or, instead, 110 and 840 mg/kg Proreside. The moment of the beginning and also the duration of positive reactions could be proved to depend on the dose. In simultaneous as well as alternating radiation- and chemotherapy evidence was given of cumulation effects. Reactions were always negative in nontreated controls.

Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enteritis; Female; Mice; Occult Blood; Podophyllin; Radiation Dosage; Radiation Injuries; Time Factors