podophyllin and Carcinoma--Squamous-Cell

A case of squamous cell carcinoma developing in a perianal condyloma acuminatum in a 38-year-old man treated for over 5 years with podophyllin is presented. Although there are many reports of malignant transformation of condyloma acuminatum in the skin and mucosal surfaces of the male and female genitalia, it is quite rare in the perianal region. In this case there were foci of carcinoma in-situ and of frank invasion, as well as areas of squamous cell carcinoma in the large perianal condyloma. The lesion was widely excised, and completely removed, and the site covered with a split-thickness graft from the thigh. Later, repeated dilatations of the anus were required. Repeated histologic examinations of condyloma acuminatum are needed to diagnose possible malignant transformation.

Topics: Adult; Animals; Anus Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Condylomata Acuminata; Humans; Male; Podophyllin

The effects of resin of podophyllin on lesions of condyloma acuminatum have posed problems to pathologists who sought to differentiate them histologically from squamous cell carcinoma in situ. The most striking histologic changes in lesions of condyloma acuminatum following application of resin of podophyllin occur within the first 48 hours. They are pallor of the epidermis secondary to both intracellular and intercellular edema, numerous necrotic keratinocytes in the lower half of the epidermis, and a marked increase in the number of mitotic figures there. Within the edematous papillary dermis, there is a scattered infiltrate of lymphocytes, histiocytes, and neutrophils. The absence of nuclear atypia, multinucleated keratinocytes, and dyskeratotic cells, and the presence of the orderly sequence of maturation of keratinocytes within the epidermis permit histologic differentiation of podophyllin-treated condyloma acuminatum from true squamous-cell carcinoma in situ. The acute histologic changes induced by podophyllin begin to wane by 72 hours after the resin has been applied. At this time, necrotic keratinocytes are found mostly within the upper portion of the epidermis and few mitotic figures are seen. By 1 week after application of podophyllin there are virtually no histologic abnormalities within the epidermis.

Topics: Adult; Carcinoma in Situ; Carcinoma, Squamous Cell; Condylomata Acuminata; Diagnosis, Differential; Humans; Podophyllin; Resins, Plant; Skin Neoplasms

Topics: Adult; Carcinoma, Squamous Cell; Condylomata Acuminata; Female; Humans; Neoplasm Metastasis; Podophyllin; Precancerous Conditions; Vulvar Diseases; Vulvar Neoplasms

Topics: Adult; Anus Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cautery; Condylomata Acuminata; Female; Humans; Male; Middle Aged; Podophyllin; Precancerous Conditions

Topics: Adult; Carcinoma, Squamous Cell; Condylomata Acuminata; Diagnosis, Differential; Humans; Lymph Node Excision; Male; Penile Diseases; Penile Neoplasms; Podophyllin; Precancerous Conditions

Topics: Aged; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Cytodiagnosis; Facial Neoplasms; Female; Humans; Male; Mandibular Neoplasms; Medulloblastoma; Methods; Methotrexate; Middle Aged; Mouth Neoplasms; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum

Topics: Bronchial Neoplasms; Carcinoma, Squamous Cell; Humans; Lymphatic Metastasis; Neoplasm Metastasis; Podophyllin; Prognosis; Remission, Spontaneous

Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Fluorouracil; Humans; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Skin Neoplasms

Topics: Agranulocytosis; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Humans; Infections; Injections, Intra-Arterial; Leukopenia; Lip Neoplasms; Melanoma; Methotrexate; Mouth Neoplasms; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Tongue Neoplasms

Topics: Carcinoma, Squamous Cell; Condylomata Acuminata; Humans; Male; Middle Aged; Podophyllin; Rectal Neoplasms

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Fluorouracil; Humans; Methotrexate; Podophyllin; Skin Neoplasms; Triaziquone; Zinc

Topics: Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Facial Neoplasms; Humans; Laryngeal Neoplasms; Liver; Male; Middle Aged; Mitosis; Neoplasm Metastasis; Neoplasm Recurrence, Local; Parotid Neoplasms; Pharyngeal Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Triaziquone

Topics: Animals; Antineoplastic Agents; Benzopyrenes; Carcinoma, Squamous Cell; Cervix Uteri; Female; Mice; Neoplasms, Experimental; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Uterine Cervical Neoplasms

Topics: Buschke-Lowenstein Tumor; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Genitalia, Male; Humans; Lymphatic Metastasis; Male; Neoplasms; Papilloma; Pathology; Penile Neoplasms; Podophyllin; Podophyllum; Scrotum; Skin Neoplasms; Surgical Procedures, Operative

Topics: Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Podophyllin; Skin Neoplasms