podophyllin and Brain-Diseases

A case of toxic encephalopathy due to podophyllin poisoning was presented. It is documented for the first time by MRI that diffuse cerebral atrophy occurred as a result of podophyllin toxicity.

Topics: Adult; Atrophy; Brain; Brain Diseases; Humans; Magnetic Resonance Imaging; Male; Podophyllin; Poisoning; Substance-Related Disorders

Two patients developed podophyllin intoxication following ingestion of a broth of the Chinese herb guijiu. The neurological manifestations are described and the pathology of the peripheral neuropathy is fully documented with ultrastructural and quantitative studies.

Topics: Adult; Brain; Brain Diseases; Follow-Up Studies; Hong Kong; Humans; Male; Medicine, Chinese Traditional; Motor Neurons; Nervous System Diseases; Neural Conduction; Neurons, Afferent; Neurotoxins; Optic Nerve; Peripheral Nerves; Phytotherapy; Podophyllin

Topics: Aluminum; Amyotrophic Lateral Sclerosis; Animals; Autopsy; Biopsy; Brain; Brain Diseases; Central Nervous System Diseases; Colchicine; Dementia; Encephalitis, Arbovirus; Humans; Microscopy, Electron; Middle Aged; Neurofibrils; Parkinson Disease; Podophyllin; Vinblastine; Vincristine