plx4032 has been researched along with Cardiomegaly* in 1 studies
1 other study(ies) available for plx4032 and Cardiomegaly
Article | Year |
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Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.
A series of N-(3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides were designed as the first class of highly selective ZAK inhibitors. The representative compound 3h strongly inhibits the kinase activity of ZAK with an IC Topics: Animals; Benzenesulfonamides; Cardiomegaly; Drug Design; Humans; MAP Kinase Kinase Kinases; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Kinases; Rats, Inbred SHR; Rats, Inbred WKY; Sulfonamides | 2017 |