plumbagin has been researched along with Breast Neoplasms in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 22 (75.86) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, A; Dandawate, P; Deshpande, J; Gaba, H; Khan, E; Khetmalas, M; Padhye, S; Sarkar, FH; Sinha, S; Venkateswara Swamy, K | 1 |
| Bratton, MR; Jones, FE; Klein Stevens, CL; Nguyen, TL; Sfondouris, ME; Sridhar, J; Townley, I | 1 |
| Ahmad, A; Dandawate, P; Deshpande, J; Khan, EM; Khetmalas, M; Padhye, S; Sarkar, F; Swamy, KV | 1 |
| Jampasri, S; Parichatikanond, W; Pinthong, D; Reabroi, S; Tungmunnithum, D | 1 |
| Ketchart, W; Mutirangura, A; Pradubyat, N; Sakunrangsit, N | 1 |
| Ketchart, W; Sakunrangsit, N | 1 |
| Alem, FZ; Bejaoui, M; Isoda, H; Rhourri-Frih, B; Villareal, MO | 1 |
| Bu, W; Cui, Z; Fan, Q; Han, X; He, XP; Ji, D; Qiao, H; Qin, A; Tang, T; Wang, T; Wang, Y; Yang, S; Yang, Y | 1 |
| Choi, WS; De, U; Ha, KT; Ha, SY; Jeon, Y; Kim, HS; Kim, IS; Kwak, JH; Lee, BM; Park, YJ; Son, JY; Yoon, S | 1 |
| Bothiraja, C; Kapare, HS; Pawar, AP; Shaikh, KS | 1 |
| Bajic, VB; Esau, L; Kaur, M; Khashab, NM; Moosa, B; Sagar, S | 1 |
| Du, L; Fan, QM; Li, HW; Tang, TT; Wang, TY; Xu, JK; Yan, W; Zhai, ZJ | 1 |
| Fan, QM; Han, XG; Qiao, H; Qin, A; Tang, TT; Wang, TY; Wang, YG; Yan, W | 1 |
| Fan, QM; Han, XG; Liu, XQ; Qiao, H; Qin, A; Tang, TT; Wang, TY; Wang, YG; Yu, ZF | 1 |
| Hemalatha, SK; Mukhopadhyay, D; Nair, AS; Pal, K; Sinha, S; Somasundaram, V; Srinivas, P | 1 |
| Hande, MP; Sameni, S | 1 |
| Kalpongnukul, N; Ketchart, W; Pisitkun, T; Sakunrangsit, N | 1 |
| Domachowska, A; Kawiak, A | 1 |
| Domachowska, A; Jaworska, A; Kawiak, A; Lojkowska, E | 1 |
| Ahmad, A; Banerjee, S; Kong, D; Sarkar, FH; Wang, Z | 1 |
| Ahn, KS; Bist, P; Hay, HS; Kannaiyan, R; Kapoor, S; Koay, ES; Kumar, AP; Li, F; Lim, LH; Manu, KA; Rajendran, P; Ramachandran, L; Ramesh, B; Sethi, G; Shanmugam, MK; Swamy, SN; Vali, S | 1 |
| Aggarwal, BB; Oyajobi, B; Sung, B | 1 |
| Bhattacharya, S; Mukhopadhyay, D; Patra, CR; Srinivas, P | 1 |
| Banerji, A; G, R; G, S; K A, T; K C, S; Nair, RS; Somasundaram, V; Srinivas, P; T, R | 1 |
| Cai, X; Guo, W; Li, W; Li, Z; Lin, Z; Liu, M; Luo, J; Wu, X; Xiao, J; Xie, J; Xu, L; Yang, Z | 1 |
| Chae, J; Kim, DM; Kim, H; Lee, JH; Park, HO; Roh, W; Yeon, JH | 1 |
| Alibiyati, A; Dong, C; Geng, ZL; Li, HT; Ma, BL; Ren, GH; Shan, MH; Sun, G; Wang, J; Zhong, H | 1 |
| Cho, CY; Hsu, YL; Kuo, PL | 1 |
| Nair, RR; Nair, S; Pillai, MR; Srinivas, G; Srinivas, P | 1 |
29 other study(ies) available for plumbagin and Breast Neoplasms
| Article | Year |
|---|---|
Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydrazones; Hydrogen Bonding; Naphthoquinones; NF-kappa B; Protein Binding; Structure-Activity Relationship | 2012 |
Identification of quinones as HER2 inhibitors for the treatment of trastuzumab resistant breast cancer.
Topics: Antibodies, Monoclonal, Humanized; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Structure; Quinones; Receptor, ErbB-2; Structure-Activity Relationship; Trastuzumab | 2014 |
Anticancer phytochemical analogs 37: synthesis, characterization, molecular docking and cytotoxicity of novel plumbagin hydrazones against breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Hydrazones; MCF-7 Cells; Models, Molecular; Molecular Structure; Naphthoquinones; Structure-Activity Relationship | 2014 |
Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Naphthoquinones; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2022 |
NADPH: Quinone oxidoreductase 1 (NQO1) mediated anti-cancer effects of plumbagin in endocrine resistant MCF7 breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Neoplasm Invasiveness; Tamoxifen | 2020 |
Plumbagin inhibited AKT signaling pathway in HER-2 overexpressed-endocrine resistant breast cancer cells.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Naphthoquinones; Nuclear Receptor Coactivator 3; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction | 2020 |
Elucidation of the effect of plumbagin on the metastatic potential of B16F10 murine melanoma cells via MAPK signalling pathway.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Melanoma; Melanoma, Experimental; Mice; Naphthoquinones; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Plant Extracts; Signal Transduction; Wound Healing | 2020 |
Targeting Osteocytes to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion Nanoparticles with Responsive Plumbagin Release.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Drug Delivery Systems; Female; Gadolinium; Humans; Luminescent Agents; Mice; Mice, Nude; Nanoparticles; Naphthoquinones; Optical Imaging; Osteocytes; Silicon Dioxide; Theranostic Nanomedicine; Zoledronic Acid | 2017 |
Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Caryophyllales; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2019 |
Development of plumbagin-loaded phospholipid-Tween® 80 mixed micelles: formulation, optimization, effect on breast cancer cells and human blood/serum compatibility testing.
Topics: Antineoplastic Agents, Phytogenic; Blood Proteins; Breast Neoplasms; Cell Survival; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Stability; Female; Hemolysis; Humans; Kinetics; MCF-7 Cells; Micelles; Nanoparticles; Nanotechnology; Naphthoquinones; Particle Size; Phospholipids; Polysorbates; Protein Binding; Solubility; Technology, Pharmaceutical | 2013 |
Cytotoxicity and apoptosis induced by a plumbagin derivative in estrogen positive MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Cell Cycle; Cell Survival; Female; Fibroblasts; Hep G2 Cells; Humans; Male; MCF-7 Cells; Naphthoquinones; Reactive Oxygen Species; Receptors, Estrogen; Structure-Activity Relationship | 2014 |
Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; Osteoclasts; Tumor Microenvironment | 2014 |
Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bone Density Conservation Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Diphosphonates; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Naphthoquinones; Proto-Oncogene Proteins c-bcl-2; Receptor, Notch1; RNA, Small Interfering; Signal Transduction; Zoledronic Acid | 2015 |
Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.
Topics: Adenine Nucleotides; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Disease Models, Animal; Drug Synergism; Female; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; Osteoclasts; Osteolysis; Phosphorylation; Random Allocation; Signal Transduction; Zoledronic Acid | 2016 |
Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Inhibitory Concentration 50; Mice, SCID; Naphthoquinones; Neoplastic Stem Cells; Xenograft Model Antitumor Assays | 2016 |
Plumbagin triggers DNA damage response, telomere dysfunction and genome instability of human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Chromosome Aberrations; Clone Cells; DNA Breaks, Double-Stranded; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Naphthoquinones; Oligonucleotide Array Sequence Analysis; Telomerase; Telomere; Telomere Homeostasis; Wound Healing | 2016 |
Plumbagin Enhances Tamoxifen Sensitivity and Inhibits Tumor Invasion in Endocrine Resistant Breast Cancer through EMT Regulation.
Topics: Anticoagulants; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Humans; Naphthoquinones; Tamoxifen | 2016 |
Plumbagin Suppresses the Invasion of HER2-Overexpressing Breast Cancer Cells through Inhibition of IKKα-Mediated NF-κB Activation.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Humans; I-kappa B Kinase; Matrix Metalloproteinase 9; Naphthoquinones; NF-kappaB-Inducing Kinase; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Transcription Factor RelA; Transcription, Genetic | 2016 |
Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Female; Heat-Shock Proteins; Humans; MCF-7 Cells; Membrane Proteins; Mitochondrial Proteins; Naphthoquinones; RNA Interference; Tamoxifen | 2017 |
Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-kappaB and Bcl-2.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Naphthoquinones; NF-kappa B; Proto-Oncogene Proteins c-bcl-2 | 2008 |
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Computer Simulation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Luciferases; Models, Biological; Naphthoquinones; Neoplasm Invasiveness; NF-kappa B; Protein Binding; Receptors, CXCR4; Stomach Neoplasms; Transcription, Genetic | 2011 |
Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Humans; I-kappa B Proteins; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoclasts; Osteogenesis; Osteolysis; RANK Ligand; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Fluoresceins; Gold; Histocytochemistry; Humans; Metal Nanoparticles; Naphthoquinones; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2011 |
Structure activity relationship of plumbagin in BRCA1 related cancer cells.
Topics: Antineoplastic Agents, Phytogenic; BRCA1 Protein; Breast Neoplasms; Cell Cycle Checkpoints; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Gene Knockout Techniques; Humans; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Naphthoquinones; Ovarian Neoplasms; Poly(ADP-ribose) Polymerases; Response Elements; Structure-Activity Relationship; Transcriptome | 2013 |
Plumbagin inhibits breast tumor bone metastasis and osteolysis by modulating the tumor-bone microenvironment.
Topics: Actins; Animals; Antigens, Differentiation; Antineoplastic Agents; Bone and Bones; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytokines; Enzyme Activation; Female; Gene Expression; Humans; Inhibitory Concentration 50; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Naphthoquinones; Neoplasm Invasiveness; NF-kappa B; Osteoclasts; Osteolysis; Protein Binding; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; TNF Receptor-Associated Factor 6; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; Female; Gene Knockdown Techniques; Haploinsufficiency; Heterozygote; Humans; MCF-7 Cells; Models, Biological; Mutation; Naphthoquinones; Phosphotransferases (Alcohol Group Acceptor); Reactive Oxygen Species; RNA, Small Interfering; Schizosaccharomyces | 2012 |
Identifying crosstalk of mTOR signaling pathway of lobular breast carcinomas.
Topics: Adipokines; Autophagy; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Naphthoquinones; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Breast Neoplasms; Cell Division; Cell Growth Processes; Cell Line, Tumor; Female; G2 Phase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway.
Topics: Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Gamma Rays; HeLa Cells; Humans; Membrane Potentials; Mitochondrial Membranes; Naphthoquinones; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2008 |