plerixafor has been researched along with Disease Models, Animal in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (6.19) | 29.6817 |
| 2010's | 89 (78.76) | 24.3611 |
| 2020's | 17 (15.04) | 2.80 |
| Authors | Studies |
|---|---|
| Abboud, D; Boeglin, D; Bonnet, D; Daubeuf, F; Frossard, N; Galzi, JL; Gasparik, V; Gizzi, P; Hachet-Haas, M; Haiech, J; Heissler, D; Hibert, M; Knehans, T; Lehalle, C; Marsol, C; Regenass, P; Riché, S; Rognan, D; Rohmer, F; Villa, P | 1 |
| Bai, R; Feng, A; Jie, X; Liang, Z; Oum, Y; Salgado, E; Shim, H; Sun, B; Sun, J; Wu, R; Xie, Y; Yoon, Y; Yu, W | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Allabauer, I; Amon, L; Cesnjevar, R; Dolff, S; Dudziak, D; Fu, J; Hoerning, A; Hoyer, PF; Kribben, A; Lehmann, CHK; Rascher, W; Wahlbuhl, M; Wang, X; Wilde, B; Witzke, O; Woelfle, J | 1 |
| Gallegos, A; Goswami, DG; Mata, J; Munoz, S; Rubio, AJ; Walker, WE | 1 |
| Dong, X; Li, L; Lu, Q; Xu, J; Yang, Z; Yi, S; Zhang, H; Zhao, J; Zhu, J | 1 |
| Chen, D; Cheng, Y; Gong, Y; Han, W; Liu, Z; Song, B; Zhang, R; Zhang, Z | 1 |
| Jin, G; Mao, W; Qin, J; Tian, M; Yi, X | 1 |
| Chen, G; Ding, L; Li, Z; Oupicky, D; Sun, M; Wang, Y | 1 |
| Feng, W; Feng, X; Liu, X; Ren, Q; Wang, H; Wang, L; Wang, R; Yang, F; Yang, X; Zhang, D; Zhang, Y; Zheng, G | 1 |
| Fillo, S; Lista, F; Mattarei, A; Megighian, A; Montecucco, C; Negro, S; Pirazzini, M; Rigoni, M; Zanetti, G | 1 |
| Adler, MW; Chen, X; Cowan, A; Eisenstein, TK; Geller, EB; Inan, S; Meissler, JJ; Rawls, SM; Tallarida, CS | 1 |
| Feng, Q; Feng, Y; Hou, FF; Liu, Y; Miao, J; Shen, W; Wu, Q; Zhou, L; Zhou, S | 1 |
| Brennan, FH; Burke, MH; Carpenter, RS; Dorrance, AM; Hall, JCE; Jiang, RR; Karunasiri, M; Marbourg, JM; Mifflin, KA; Mo, XM; Popovich, PG | 1 |
| Hu, H; Jiang, C; Li, R; Ma, X; Wei, L; Zhao, J | 1 |
| Guo, J; Hu, H; Jiang, C; Li, R; Ma, X; Zhao, J | 1 |
| Barbiro, B; Ezra, A; Gavriel, Y; Rabinovich-Nikitin, I; Solomon, B | 1 |
| Gao, H; Huang, XJ; Liang, S; Liu, J; Liu, R; Wu, N; Xu, LP; Zhang, XH | 1 |
| Fan, B; Fu, Y; Gao, F; Jiang, T; Li, T; Li, X; Li, Y; Liu, P; Qin, X; Sun, H; Wang, Q; Wang, Y; Zheng, Q; Zhou, X | 1 |
| Li, D; Liu, X; Miao, X; Wang, S; Xu, GY; Zhu, HY | 1 |
| Cui, ZL; Gu, C; Gu, JH; Lu, YW; Zou, XF | 1 |
| Fang, XG; Huang, QH; Li, ZF; Liu, JM; Yang, PF; Zhao, R | 1 |
| Magga, J; Mustonen, E; Renko, O; Ruskoaho, H; Rysä, J; Serpi, R; Tolonen, AM | 1 |
| Coelho, AL; Espindola, MS; Habiel, DM; Hogaboam, CM | 1 |
| Ackerman, JJH; Beeman, SC; Duan, C; Engelbach, JA; Garbow, JR; Ge, X; Perez-Torres, CJ; Rich, KM; Tsien, CI; Yang, R; Yuan, L | 1 |
| Li, YZ; Luo, Q; Piao, JM; Wu, W; Yang, ZX; Yu, JL | 1 |
| Adair, JE; Burtner, CR; Chan, F; Felsburg, PJ; Hubbard, NW; Humbert, O; Humphrys, D; Kiem, HP; Norgaard, ZK; O'Donnell, P; Rajawat, YS; Rawlings, DJ; Scharenberg, AM; Torgerson, TR; Trobridge, GD | 1 |
| Ahmadi, AR; Anders, RA; Cameron, AM; Chicco, M; Creamer, TJ; Dor, FJMF; IJzermans, JNM; Sun, Z; Wesson, RN; Williams, GM | 1 |
| Han, AR; Hwang, HS; Kim, HJ; Lee, JY; Min, WS; Park, GS | 1 |
| Gou, W; Guo, Q; Liu, S; Lu, Q; Lu, S; Meng, H; Peng, J; Wang, A; Wang, C; Wang, X; Wang, Y; Xu, W; Xu, X; Yuan, M | 1 |
| Willyard, C | 1 |
| Ahmadi, AR; Guo, Z; Liu, JO; Peiffer, BJ; Peng, H; Qi, L; Sun, Z; Wang, Y | 1 |
| Dong, W; Hu, X; Jiao, W; Tang, H; Xu, Y; Zeng, S; Zhang, Z | 1 |
| Amador, C; Becker, M; Hang, Y; Hyde, RK; Oupický, D; Richter, L; Wang, Y; Williams, J; Xie, Y | 1 |
| Ahmadi, AR; Burdick, J; Cameron, AM; Chen, M; Iwasaki, K; Katsumata, K; Qi, L; Sun, Z; Tsuchida, A; Wang, W | 1 |
| Bonnet, D; Bordenave, J; Cumont, A; Frossard, N; Galzi, JL; Guignabert, C; Hibert, M; Huertas, A; Humbert, M; Marsol, C; Phan, C; Savale, L; Thuillet, R; Tu, L | 1 |
| Charbonneau, C; Chen, Q; Sun, X; Terek, RM; Wei, L; Yang, W | 1 |
| Fujita, K; Hatano, K; Kaneda, Y; Murakami, K; Nagahara, A; Nakai, Y; Nakayama, M; Nimura, K; Nonomura, N; Tsuchiya, M; Uemura, M; Yamaguchi, S | 1 |
| Borjesson, DL; Chung, DJ; Ghassemi, E; Granick, JL; Sagy, M; Toupadakis, CA; Wong, A; Yellowley, CE | 1 |
| Gao, H; Hao, C; Hong, S; Nayra, C; Rojas, M; Shim, H; Shu, HK; Torres-Gonzalez, E; Xu, K; Yoon, Y | 1 |
| Bae, JS; Choi, JY; Im, JY; Jin, HK; Kim, N; Kim, SY; Lee, JK; Min, WK; Park, MH | 1 |
| Chen, SC; He, QW; Hu, B; Huang, M; Huang, Y; Li, YN; Mao, L; Wang, MD; Xia, YP; Zheng, L | 1 |
| Allen, RJ; Haberman, ID; Lin, CD; Nguyen, PD; Saadeh, PB; Schachar, J; Soares, MA; Szpalski, C; Warren, SM | 1 |
| Cameron, AM; Cui, Z; Gao, B; Lin, Q; Liu, JO; Maeda, H; Montgomery, RA; Sun, Z; Wang, Y; Wesson, RN; Williams, GM | 1 |
| Li, J; Oupický, D | 1 |
| Allaire, E; Dai, J; Franck, G; Gervais, M; Michineau, S; Wagner-Ballon, O | 1 |
| Dai, Z; Fan, J; Sun, Q; Tan, C; Wang, Z; Xu, M; Zhou, J; Zhu, H | 1 |
| Abdelhak, B; Frietag, C; Menichella, DM; Miller, RJ; Ren, D; Shum, A | 1 |
| Bachelerie, F; Balabanian, K; Bignon, A; Boujedidi, H; Cassard-Doulcier, AM; Emilie, D; Gary-Gouy, H; Hemon, P; Naveau, S; Perlemuter, G; Prévot, S; Renoud, ML; Robert, O; Tharinger, H | 1 |
| Dedobbeleer, M; Denne, A; Di Valentin, E; Goffart, N; Kroonen, J; Martinive, P; Rogister, B | 1 |
| Colon, DM; Goodrich, AD; Hematti, P; Jeanblanc, CM; Kim, J; Varain, NM; Zanjani, ED | 1 |
| Haase, T; Kamann, S; Krost, A; Langwieser, N; Peter, J; Rüder, C; Zohlnhöfer, D | 1 |
| Chen, X; Kiesewetter, DO; Lu, J; Niu, G; Teng, G; Wang, Y; Wang, Z; Yue, X | 1 |
| Alcoceba, M; Blanco, O; Bosch, R; Casanova, I; Céspedes, MV; Dieguez-Gonzalez, R; Gallardo, A; Gonzalez-Díaz, M; Grañena, A; Mangues, R; Moreno, MJ; Mozos, A; Novelli, S; Pavón, MÁ; Sierra, J | 1 |
| Araujo-Pires, AC; Biguetti, CC; Campanelli, AP; Garlet, GP; Letra, A; Repeke, CE; Rodini, Cde O; Silva, RM; Trombone, AP | 1 |
| Anagnostopoulos, A; Arsenakis, M; Athanasiou, E; Baliakas, P; Constantinou, V; Gkountis, A; Papayannopoulou, T; Psatha, N; Sgouramali, E; Siametis, A; Stamatoyannopoulos, G; Yannaki, E | 1 |
| Butschkau, A; Genz, B; Vollmar, B; Wagner, NM | 1 |
| Henderson, R; Layliev, J; Marchac, A; Rubin, MS; Saadeh, PB; Szapalski, C; Szpalski, C; Tanaka, R; Warren, SM | 1 |
| Bye, CR; Parish, CL; Somaa, FA; Thompson, LH | 1 |
| Blanchard, J; Caldwell, CC; Edwards, MJ; Freeman, CM; Kuethe, JW; Lentsch, AB; Nojima, H; Quillin, RC; Schuster, R; Wilson, GC | 1 |
| Cai, Y; Dong, K; Gao, Y; Geng, J; Han, X; Jin, Z; Li, H; Li, Y; Liang, W; Lipinski, M; Liu, M; Najafov, A; Pandolfi, PP; Peng, T; Qi, C; Sun, A; Xia, H; Xiao, J; Xiong, Y; Xu, D; Yu, Q; Yuan, J; Zhang, Q; Zhang, T; Zhu, H | 1 |
| Drummond, S; Hehre, D; Huang, J; Ramachandran, S; Suguihara, C; Torres, E; Young, KC | 1 |
| Antunes, AR; Ruscher, K; van der Maten, G; Walter, HL; Wieloch, T | 1 |
| Biordi, L; Di Cesare, E; Festuccia, C; Gravina, GL; Jannini, EA; Mancini, A; Mattei, C; Muzi, P; Pompili, S; Ricevuto, E; Ventura, L | 1 |
| Byrne, M; Chu, PY; Horlock, D; Jandeleit-Dahm, K; Kaye, DM; Nelson, E; Walder, K; Williams, D; Zimmet, P | 1 |
| Bunjhoo, H; Cao, Y; Chen, H; Cheng, S; Liu, J; Teng, J; Wang, C; Xie, J; Xiong, W; Xu, X; Xu, Y | 1 |
| Cao, Y; Jolkkonen, J; Li, Y; Qu, H; Xiao, T; Zhao, C; Zhao, M; Zhao, S; Zhao, Y | 1 |
| Bernasconi, P; Boni, M; Calvello, C; Dambruoso, I; Farina, M | 1 |
| Chen, Y; Ji, P; Jiang, LH; Tang, XJ; Wang, XY | 1 |
| Billett, HH; Branch, C; Choi, E; Cui, MH; Mohandas, N; Shi, PA; Yazdanbakhsh, K | 1 |
| Liu, CL; Lyle, MJ; Miao, CH; Shin, SC | 1 |
| Aknin, ML; Bachelerie, F; Berrebi, D; Gaudin, F; Hémon, P; Meuris, F | 1 |
| Abdel Mola, AF; Balfas, MA; Fahmi, MK; Hamed, EA; Makhlouf, MM; Mohamed Farghaly, HS | 1 |
| Cheung, CW; Chung, SK; Luo, X; Pan, Z; Sun, L; Tai, WL; Xia, Z | 1 |
| Chao, YC; Li, X; Wang, Y; Xie, F; Yue, Y | 1 |
| Baracos, VE; Bathe, OF; Cervo, L; Giavazzi, R; Lecker, SH; Martinelli, GB; Olivari, D; Ottoboni, L; Piccirillo, R; Re Cecconi, AD; Resovi, A; Stretch, C; Talamini, L | 1 |
| Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH | 1 |
| Barbiro, B; Ezra, A; Rabinovich-Nikitin, I; Rabinovich-Toidman, P; Solomon, B | 1 |
| Chen, A; Cheng, P; Dong, Y; Guo, F; Huang, H; Liu, H; Qin, L; Xu, F; Yang, Q; Zhang, X | 1 |
| Drucker, DJ; Fujishima, H; Fujita, H; Morii, T; Narita, T; Sato, T; Seino, Y; Shimizu, T; Takahashi, T; Takashima, S; Tsukiyama, K; Yamada, Y | 1 |
| Hu, X; Xu, Y; Zeng, S; Zhang, Q; Zhang, Z | 1 |
| Cher, ML; Chinni, SR; Conley-LaComb, MK; Heath, EI; Kim, S; Li, Y; Semaan, L; Singareddy, R | 1 |
| Hu, X; Xu, Y; Xue, W; Zeng, S; Zhang, Q; Zhang, X; Zhang, Z | 1 |
| Hong, X; Hou, FF; Liu, Y; Luo, C; Miao, J; Mo, H; Tang, L; Wang, Y; Wu, Q; Zhou, L | 1 |
| He, QW; Hu, B; Huang, M; Jin, HJ; Li, M; Li, YN; Mao, L; Wan, Y; Xia, YP | 1 |
| Liu, T; Mu, X; Sun, X; Xiao, T; Zhao, C; Zhao, M; Zhou, Z; Zhu, G | 1 |
| Chen, XY; Du, LX; Liu, JM; Liu, ZL; Long, XH; Zhao, K; Zhou, Y | 1 |
| Diamond, MS; Klein, RS; McCandless, EE; Zhang, B | 1 |
| Arms, L; Girard, BM; Vizzard, MA | 1 |
| Lee, E; Rewolinski, D | 1 |
| Chen, Y; Fan, Y; Frenzel, T; Liu, J; Shen, F; Su, H; Yang, GY; Ye, J; Young, WL; Zhu, W | 1 |
| Aoyama, T; Fujiwara, H; Fujiwara, T; Goto, K; Kanamori, H; Kawaguchi, T; Kawamura, I; Maruyama, R; Minatoguchi, S; Shiraki, T; Takemura, G; Takeyama, T; Tsujimoto, A; Watanabe, T | 1 |
| Chen, Y; Han, H; Hong, D; Qiao, H; Tong, Y; Wu, Y; Xu, W; Yang, J; Zhou, C | 1 |
| Hales, CA; Yu, L | 1 |
| Bae, JS; Jin, HK; Lee, JE; Lee, JK; Min, WK; Schuchman, EH; Shin, JW | 1 |
| Ii, M; Jujo, K; Kamide, C; Klyachko, E; Losordo, DW; Misener, S; Renault, MA; Roncalli, J; Tanaka, T; Thorne, T; Tongers, J | 1 |
| Allen, RJ; Allori, AC; Davidson, EH; McCarthy, JG; Paek, GK; Saadeh, PB; Sailon, A; Tutela, JP; Wang, XX; Warren, SM | 1 |
| Butala, P; Canizares, O; Davidson, EH; Knobel, D; Saadeh, PB; Sultan, SM; Tutela, JP; Wagner, IJ; Warren, SM | 1 |
| Fandel, TM; Lee, JU; Lee, SM; Lohela, M; Noble-Haeusslein, LJ; Trivedi, A; Werb, Z; Zhang, H | 1 |
| Kumar, S; Ponnazhagan, S | 1 |
| Wang, LY; Xu, QY; Yuan, F; Yuan, YZ | 1 |
| Deng, L; Guindon, J; Hohmann, AG; Makriyannis, A; Thakur, GA; Vemuri, VK; White, FA | 1 |
| Abdelouahab, H; Bawa, O; Betems, A; Coppo, P; De Botton, S; Fujii, N; Gonin, P; Ito, M; Joulin, V; Louache, F; Opolon, P; Pasquier, F; Patel, S; Shen, S; Solary, E; Vainchenker, W; Willekens, C; Wittner, M; Zhang, Y | 1 |
| Barlic-Dicen, J; Herlea-Pana, O; Heuser-Baker, J; Iida, R; Wang, Q; Yao, L; Zou, MH | 1 |
| Dohrmann, T; Drenckhan, A; Effenberger, K; Forberich, E; Gros, SJ; Hoffman, RM; Izbicki, JR; Kaifi, JT; Kurschat, N; Pantel, K; Reichelt, U | 1 |
| Hajishengallis, G; McIntosh, ML | 1 |
| Asahi, M; Clarke, T; Hagiwara, N; Ii, M; Ito, A; Jujo, K; Kamide, C; Klyachko, E; Losordo, DW; Misener, S; Qin, G; Renault, MA; Roncalli, J; Sekiguchi, H; Tanaka, T; Thorne, T; Tongers, J; Tsurumi, Y | 1 |
| Garbow, JR; Jackson, E; Luker, GD; Luker, KE; Piwnica-Worms, D; Prior, JL; Smith, MC | 1 |
| Billiau, A; Bridger, G; De Klerck, B; Geboes, L; Hatse, S; Kelchtermans, H; Matthys, P; Meyvis, Y; Schols, D; Vermeire, K | 1 |
| Lukacs, NW; Smit, JJ | 1 |
| Calderone, A; Clement, R; El-Helou, V; Gillis, MA; Gosselin, H; Proulx, C; Villeneuve, L | 1 |
| Cotman, CW; Parachikova, A | 1 |
| De Clercq, E; Nakagaki, K; Schols, D; Tabira, T; Takahashi, K | 1 |
3 review(s) available for plerixafor and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Benzylamines; Bone Marrow; Cell Hypoxia; Cell Lineage; Chemokine CXCL12; Clinical Trials as Topic; Combined Modality Therapy; Cord Blood Stem Cell Transplantation; Cyclams; Diphosphonates; Disease Models, Animal; Heterocyclic Compounds; Humans; Intercellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Neoplasm Proteins; Neoplastic Stem Cells; Protein Kinase Inhibitors; Receptors, CXCR4; Stem Cell Niche; Stromal Cells; Transplantation, Heterologous; Tumor Microenvironment | 2016 |
Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury.
Topics: Acute Kidney Injury; Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterocyclic Compounds; Humans; Kidney; Matrix Metalloproteinase 9; Mice; Receptors, CXCR4; Signal Transduction | 2017 |
A closer look at chemokines and their role in asthmatic responses.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Benzylamines; Chemokines; Cyclams; Dendritic Cells; Disease Models, Animal; Eosinophils; Heterocyclic Compounds; Humans; Mast Cells; Receptors, Chemokine; Respiratory System; T-Lymphocytes | 2006 |
110 other study(ies) available for plerixafor and Disease Models, Animal
| Article | Year |
|---|---|
Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL12; Disease Models, Animal; Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; Humans; Hypereosinophilic Syndrome; Hypersensitivity; Male; Mice, Inbred BALB C; Models, Molecular; Pyrimidinones; Receptors, CXCR4; Structure-Activity Relationship | 2018 |
Development of CXCR4 modulators based on the lead compound RB-108.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Inflammation; Mice; Mice, Inbred C57BL; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Structure-Activity Relationship | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
CXCR4 blockade reduces the severity of murine heart allograft rejection by plasmacytoid dendritic cell-mediated immune regulation.
Topics: Allografts; Animals; Benzylamines; Biomarkers; Cyclams; Dendritic Cells; Disease Models, Animal; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunomodulation; Mice; Prognosis; Receptors, CXCR4; Sirolimus; T-Lymphocytes, Regulatory; Transplantation Immunology; Treatment Outcome | 2021 |
Large Peritoneal Macrophages and Transitional Premonocytes Promote Survival during Abdominal Sepsis.
Topics: Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Ligation; Macrophages; Macrophages, Peritoneal; Male; Mice; Monocytes; Receptors, CXCR4; Sepsis | 2021 |
Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization.
Topics: Animals; Benzylamines; Colitis; Cyclams; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Ganglia, Spinal; Hyperalgesia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Signal Transduction; Spinal Cord; Urinary Bladder Diseases; Urination | 2022 |
Stromal cell-derived factor-1 exerts opposing roles through CXCR4 and CXCR7 in angiotensin II-induced adventitial remodeling.
Topics: Adventitia; Angiotensin II; Animals; Benzylamines; Cell Movement; Cell Proliferation; Chemokine CXCL12; Collagen; Cyclams; Disease Models, Animal; Fibroblasts; Fibrosis; Hypertension; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, CXCR; Receptors, CXCR4; Signal Transduction; Wound Healing | 2022 |
CXCL12 promotes proliferation of radial glia like cells after traumatic brain injury in rats.
Topics: Animals; Astrocytes; Benzylamines; Brain Injuries, Traumatic; Cell Proliferation; Cerebral Cortex; Chemokine CXCL12; Corpus Callosum; Cyclams; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Ependymoglial Cells; Fatty Acid-Binding Protein 7; Fluorescent Antibody Technique; Male; Microtubule-Associated Proteins; Nestin; Neurogenesis; Neurons; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; SOXB1 Transcription Factors; Vimentin | 2020 |
Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes.
Topics: Acute Lung Injury; Animals; Benzylamines; Cyclams; Disease Models, Animal; Emulsions; Heterocyclic Compounds; Idiopathic Pulmonary Fibrosis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Polymers; Receptors, CXCR4; RNA, Small Interfering; Survival Rate; Tissue Distribution | 2019 |
Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model.
Topics: Adolescent; Adoptive Transfer; Animals; Antineoplastic Agents, Immunological; Benzylamines; Bone Marrow; Cell Movement; Chemokine CCL3; Chemokine CXCL12; Child; Child, Preschool; Cyclams; Disease Models, Animal; Disease Progression; Female; Forkhead Transcription Factors; Gene Expression Regulation, Leukemic; Gene Knock-In Techniques; Heterocyclic Compounds; Humans; Leukemia, Myeloid, Acute; Male; Maraviroc; Mice; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Receptors, CCR; Signal Transduction; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2020 |
A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage.
Topics: Animals; Axons; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Indazoles; Mice; Mice, Inbred C57BL; Nerve Regeneration; Piperidines; Pyridines; Receptors, CXCR4; Schwann Cells; Sciatic Nerve; Sciatic Neuropathy | 2019 |
Chemokine Receptor Antagonists in Combination with Morphine as a Novel Strategy for Opioid Dose Reduction in Pain Management.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Benzylamines; Cyclams; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Heterocyclic Compounds; Maraviroc; Morphine; Pain Management; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Chemokine; Surgical Wound | 2020 |
C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β-catenin pathway.
Topics: Amino Acid Motifs; Animals; Benzylamines; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Chemokine CXCL12; Cyclams; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Glycogen Synthase Kinase 3 beta; Humans; Janus Kinase 2; Kidney; Matrix Metalloproteinase 7; Mice; Pyrimidinones; Receptors, CXCR4; Renal Insufficiency, Chronic; STAT3 Transcription Factor; STAT6 Transcription Factor | 2020 |
Spinal cord injury causes chronic bone marrow failure.
Topics: Animals; Benzylamines; Bone Marrow; Bone Marrow Cells; Bone Marrow Failure Disorders; Cell Proliferation; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Hematopoiesis; Hematopoietic Stem Cells; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Receptors, CXCR4; Signal Transduction; Spinal Cord Injuries | 2020 |
Plerixafor stimulates adhesive activity and endothelial regeneration of endothelial progenitor cells via elevating CXCR7 expression.
Topics: Animals; Benzylamines; Carotid Artery Injuries; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cyclams; Disease Models, Animal; Endothelial Progenitor Cells; Humans; Rats; Rats, Sprague-Dawley; Re-Epithelialization; Receptors, CXCR | 2020 |
AMD3100 and SDF‑1 regulate cellular functions of endothelial progenitor cells and accelerate endothelial regeneration in a rat carotid artery injury model.
Topics: Animals; Benzylamines; Carotid Artery Injuries; Cell Adhesion; Cell Proliferation; Cells, Cultured; Chemokine CXCL12; Cyclams; Disease Models, Animal; Drug Synergism; Endothelial Progenitor Cells; Female; Fibronectins; Human Umbilical Vein Endothelial Cells; Humans; Pregnancy; Rats; Receptors, CXCR; Receptors, CXCR4; Regeneration; Up-Regulation; Young Adult | 2020 |
Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer's Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-HIV Agents; Benzylamines; Biomarkers; Cognitive Dysfunction; Cyclams; Disease Models, Animal; Inflammation; Inflammation Mediators; Injections, Intraventricular; Injections, Subcutaneous; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments | 2020 |
γδ T Cells May Aggravate Acute Graft-Versus-Host Disease Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation.
Topics: Adolescent; Adult; Animals; Benzylamines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis, Leukocyte; Coculture Techniques; Cyclams; Disease Models, Animal; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Intraepithelial Lymphocytes; Male; Mice, Inbred NOD; Middle Aged; Receptors, Antigen, T-Cell, alpha-beta; Receptors, CXCR4; Signal Transduction; Transplantation, Homologous; Young Adult | 2021 |
CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification.
Topics: Animals; Atrial Fibrillation; Benzylamines; Case-Control Studies; Chemokine CXCL12; Computational Biology; Cyclams; Databases, Genetic; Disease Models, Animal; Electrocardiography; Fibrosis; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Heart Atria; Humans; Inflammation; Macrophages; Mice, Inbred C57BL; Phosphorylation; Receptors, CXCR4; Signal Transduction; T-Lymphocytes; Vascular Remodeling | 2021 |
Up-regulation of CXCR4 expression contributes to persistent abdominal pain in rats with chronic pancreatitis.
Topics: Abdominal Pain; Analysis of Variance; Animals; Anti-HIV Agents; Benzylamines; Cells, Cultured; Cyclams; Disease Models, Animal; Ganglia, Spinal; Heterocyclic Compounds; Male; Membrane Potentials; Pain Measurement; Pancreatitis, Chronic; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Receptors, Interleukin-8B; RNA, Messenger; Up-Regulation | 2017 |
CXC Chemokine Receptor Type 4 Antagonism Ameliorated Allograft Fibrosis in Rat Kidney Transplant Model.
Topics: Allografts; Animals; Benzylamines; Chemokine CXCL12; Collagen Type IV; Cyclams; Disease Models, Animal; Down-Regulation; Fibrosis; Graft Survival; Heterocyclic Compounds; Kidney; Kidney Diseases; Kidney Transplantation; Male; Rats, Inbred F344; Rats, Inbred Lew; Receptors, CXCR4; Signal Transduction; Time Factors; Transforming Growth Factor beta1 | 2017 |
Stromal cell-derived factor 1α facilitates aneurysm remodeling in elastase-induced rabbit saccular aneurysm.
Topics: Angiography, Digital Subtraction; Animals; Antigens, CD; Benzylamines; Cadherins; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Endothelium, Vascular; Heterocyclic Compounds; Intracranial Aneurysm; Male; Microscopy, Electron, Scanning; Pancreatic Elastase; Rabbits; Vascular Remodeling | 2018 |
SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.
Topics: Adult Stem Cells; Animals; Benzylamines; Cell Movement; Cells, Cultured; Chemokine CXCL12; Cyclams; Disease Models, Animal; Gene Expression Regulation; Heart Atria; Heart Ventricles; Heterocyclic Compounds; Male; Myocardial Infarction; Myocardium; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Regeneration | 2018 |
Modeling Idiopathic Pulmonary Fibrosis in Humanized Severe Combined Immunodeficient Mice.
Topics: Animals; Antibodies, Neutralizing; Benzylamines; Cyclams; Disease Models, Animal; Fibroblasts; Heterocyclic Compounds; Humans; Idiopathic Pulmonary Fibrosis; Interleukin-13; Lung; Mice, SCID; Phenotype; Receptors, CXCR4; Receptors, Interleukin-4 | 2018 |
Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain.
Topics: Animals; Benzylamines; Brain; Cyclams; Disease Models, Animal; Disease Progression; Female; Heterocyclic Compounds; Hypoxia-Inducible Factor 1, alpha Subunit; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Necrosis; Radiation Injuries, Experimental; Receptors, CXCR4; Topotecan | 2018 |
MicroRNA-381 Favors Repair of Nerve Injury Through Regulation of the SDF-1/CXCR4 Signaling Pathway via LRRC4 in Acute Cerebral Ischemia after Cerebral Lymphatic Blockage.
Topics: Animals; Benzylamines; Brain Ischemia; Chemokine CXCL12; Cyclams; Disease Models, Animal; Down-Regulation; Heterocyclic Compounds; Hippocampus; Infarction, Middle Cerebral Artery; Interleukin-1beta; Leucine-Rich Repeat Proteins; Male; MicroRNAs; Mitogen-Activated Protein Kinase 3; Proteins; Rats; Rats, Wistar; Receptors, CXCR4; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2018 |
Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.
Topics: Animals; Benzylamines; CD4-CD8 Ratio; Cyclams; Disease Models, Animal; Dog Diseases; Dogs; Genetic Therapy; Genetic Vectors; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Humans; Phosphoglycerate Kinase; Spumavirus; X-Linked Combined Immunodeficiency Diseases | 2018 |
Stem Cell Mobilization Is Lifesaving in a Large Animal Preclinical Model of Acute Liver Failure.
Topics: Animals; Benzylamines; Cyclams; Disease Models, Animal; Flow Cytometry; Galactosamine; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Immunohistochemistry; Liver Failure, Acute; Male; Swine | 2018 |
Enhanced Anti-Leukemic Effects through Induction of Immunomodulating Microenvironment by Blocking CXCR4 and PD-L1 in an AML Mouse Model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Benzylamines; Cell Line, Tumor; Cyclams; Cytarabine; Disease Models, Animal; Heterocyclic Compounds; Humans; Immunomodulation; Immunotherapy; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Myeloid Progenitor Cells; Receptors, CXCR4; Tumor Microenvironment | 2019 |
The optimal time to inject bone mesenchymal stem cells for fracture healing in a murine model.
Topics: Animals; Benzylamines; Bone Density; Bone Regeneration; Cell Engineering; Chemokine CXCL12; Cyclams; Disease Models, Animal; Femoral Fractures; Femur; Fracture Healing; Gene Expression; Heterocyclic Compounds; Luminescent Proteins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Receptors, CXCR4; Red Fluorescent Protein; Signal Transduction; Time Factors; Transfection; X-Ray Microtomography | 2018 |
Unlocking the secrets of scar-free skin healing.
Topics: Adipocytes; Adult; Aging; Animals; Antlers; Benzylamines; Bioartificial Organs; Bone Morphogenetic Proteins; Burns; Chemokine CXCL12; Cicatrix; Cyclams; Disease Models, Animal; Female; Fetus; Fibroblasts; Hair Follicle; Heterocyclic Compounds; Humans; Keratinocytes; Male; Mice; Prenatal Injuries; Regeneration; Regenerative Medicine; Reindeer; Skin; Skin Physiological Phenomena; Skin Transplantation; Skin, Artificial; Surgery, Plastic; Wound Healing; Young Adult | 2018 |
Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing.
Topics: Animals; Benzylamines; Bone Morphogenetic Proteins; Cyclams; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Synergism; Female; Gene Knockout Techniques; Heterocyclic Compounds; Humans; Jurkat Cells; Ligands; Peptides, Cyclic; Phosphorylation; Rats; Receptors, CXCR4; Signal Transduction; Smad1 Protein; Smad5 Protein; Tacrolimus; Tacrolimus Binding Protein 1A; Wound Healing | 2019 |
SDF‑1/CXCR4 induces epithelial‑mesenchymal transition through activation of the Wnt/β‑catenin signaling pathway in rat chronic allograft nephropathy.
Topics: Allografts; Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Heterocyclic Compounds; Immunohistochemistry; Kidney Diseases; Kidney Transplantation; Male; Rats; Receptors, CXCR4; RNA, Long Noncoding; Transplantation, Homologous; Wnt Signaling Pathway | 2019 |
Use of polymeric CXCR4 inhibitors as siRNA delivery vehicles for the treatment of acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Benzylamines; Cell Line, Tumor; Cholesterol; Core Binding Factor Alpha 2 Subunit; Cyclams; Disease Models, Animal; Drug Carriers; Female; Gene Knock-In Techniques; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Transgenic; Nanoparticles; Oncogene Proteins, Fusion; Polyelectrolytes; Receptors, CXCR4; RNA, Small Interfering | 2020 |
Pharmacological Mobilization and Recruitment of Stem Cells in Rats Stops Abdominal Adhesions After Laparotomy.
Topics: Abdomen; AC133 Antigen; Animals; Benzylamines; Case-Control Studies; Chemokine CXCL12; Cyclams; Disease Models, Animal; Hepatocyte Growth Factor; Heterocyclic Compounds; Laparotomy; Macrophages; Peritoneum; Rats; Rats, Inbred Lew; Stem Cells; Tacrolimus; Tissue Adhesions | 2019 |
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.
Topics: Animals; Benzylamines; Cell Movement; Cell Proliferation; Cells, Cultured; Chalcones; Chemokine CXCL2; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pericytes; Pulmonary Artery; Pyrimidinones; Rats, Wistar; Receptors, CXCR4; Signal Transduction; Vascular Remodeling; Vascular Resistance | 2020 |
CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis.
Topics: Animals; Benzylamines; Cell Growth Processes; Cell Line, Tumor; Chondrosarcoma; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Humans; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasm Metastasis; Receptors, CXCR4; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Survival Analysis; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2013 |
Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc.
Topics: Animals; Antineoplastic Agents; Benzylamines; Carcinogenesis; Cell Line, Tumor; Cyclams; Disease Models, Animal; Docetaxel; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; Male; MAP Kinase Signaling System; Mice, Nude; Mice, SCID; Neoplasm, Residual; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Receptors, CXCR4; Signal Transduction; Taxoids | 2013 |
Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model.
Topics: Animals; Benzylamines; Bone Density; Bone Marrow; Cell Culture Techniques; Cells, Cultured; Cyclams; Disease Models, Animal; Endothelial Cells; Femoral Fractures; Fracture Healing; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Heterocyclic Compounds; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Stem Cells | 2013 |
Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis.
Topics: Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Lung; Mesenchymal Stem Cells; Mice; Pulmonary Fibrosis; Pyrimidines; Radiation Injuries; Radiation Injuries, Experimental; Receptors, CXCR4; Tomography, X-Ray Computed | 2013 |
AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells.
Topics: Animals; Benzylamines; Bone Density Conservation Agents; Bone Marrow Cells; Cell Differentiation; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Heterocyclic Compounds; Mice; Mice, Inbred C57BL; Osteoporosis; Ovariectomy; Receptors, CXCR4 | 2014 |
Endogenous endothelial progenitor cells participate in neovascularization via CXCR4/SDF-1 axis and improve outcome after stroke.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Brain; Brain Ischemia; Capillaries; Cerebrovascular Circulation; Chemokine CXCL12; Cyclams; Disease Models, Animal; Endothelial Progenitor Cells; Heterocyclic Compounds; Infarction, Middle Cerebral Artery; Male; Neovascularization, Physiologic; Rats, Sprague-Dawley; Receptors, CXCR4; Severity of Illness Index; Stroke | 2014 |
Combination therapy accelerates diabetic wound closure.
Topics: Animals; Becaplermin; Benzylamines; Cyclams; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Heterocyclic Compounds; Mice; Neovascularization, Physiologic; Proto-Oncogene Proteins c-sis; Skin Ulcer; Stem Cells; Wound Healing; Wounds and Injuries | 2014 |
Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus.
Topics: Animals; Benzylamines; Cell Lineage; Cicatrix; Cyclams; Disease Models, Animal; Drug Synergism; Hair Follicle; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Immunosuppressive Agents; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mice, Knockout; Rats, Inbred Strains; Receptors, CXCR4; Regenerative Medicine; Skin; Tacrolimus; Wound Healing | 2014 |
Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor.
Topics: Animals; Anticarcinogenic Agents; Benzylamines; Chemical Phenomena; Chemokine CXCL12; Cyclams; Disease Models, Animal; Drug Delivery Systems; Female; Hep G2 Cells; Heterocyclic Compounds; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Plasmids; Protein Binding; Receptors, CXCR4; Transfection | 2014 |
Chemokine (C-X-C motif) receptor 4 blockade by AMD3100 inhibits experimental abdominal aortic aneurysm expansion through anti-inflammatory effects.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Benzylamines; Bone Marrow Transplantation; Calcium Chloride; Chemokine CXCL12; Chemotaxis; Cyclams; Disease Models, Animal; Green Fluorescent Proteins; Guinea Pigs; Heterocyclic Compounds; Heterografts; Humans; Inflammation Mediators; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Smooth Muscle; Rats; Rats, Inbred F344; Receptors, CXCR4; Time Factors; U937 Cells | 2014 |
Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo.
Topics: Animals; Benzylamines; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Immunohistochemistry; Immunosuppressive Agents; Liver Neoplasms; Lymphatic Metastasis; Rats; Receptors, CXCR4; Tacrolimus | 2014 |
CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy.
Topics: Animals; Benzylamines; Cells, Cultured; Cyclams; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Pain Measurement; Pain Threshold; Receptors, CXCR4; Receptors, Leptin; Sensory Receptor Cells; Signal Transduction | 2014 |
CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients.
Topics: Adult; Animals; Benzylamines; CD4-Positive T-Lymphocytes; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Humans; Lymphocyte Count; Male; Mice, Inbred C57BL; Mice, Obese; Middle Aged; Non-alcoholic Fatty Liver Disease; Receptors, CXCR; Receptors, CXCR4; Up-Regulation | 2015 |
Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling.
Topics: Animals; Benzylamines; Brain Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Glioblastoma; Heterocyclic Compounds; Humans; Lateral Ventricles; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Receptors, CXCR4; Signal Transduction | 2015 |
Influence of a dual-injection regimen, plerixafor and CXCR4 on in utero hematopoietic stem cell transplantation and engraftment with use of the sheep model.
Topics: Animals; Antigens, CD34; Benzylamines; Cell Differentiation; Cell Lineage; Cells, Cultured; Chemokine CXCL12; Clinical Protocols; Cyclams; Disease Models, Animal; Female; Fetus; Genetic Diseases, Inborn; Graft Survival; Hematopoietic Stem Cell Transplantation; Heterocyclic Compounds; Humans; Immunomodulation; Mesenchymal Stem Cells; Pregnancy; Receptors, CXCR4; Sheep | 2014 |
Combinatorial G-CSF/AMD3100 treatment in cardiac repair after myocardial infarction.
Topics: Animals; Benzylamines; Cyclams; Disease Models, Animal; Drug Therapy, Combination; Granulocyte Colony-Stimulating Factor; Heart; Heterocyclic Compounds; Male; Mice; Myocardial Infarction | 2014 |
[(18)F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke.
Topics: Animals; Benzylamines; Cyclams; Disease Models, Animal; Fluorine Radioisotopes; Heterocyclic Compounds; Male; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Stroke | 2014 |
CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.
Topics: Animals; Benzylamines; Cell Line, Tumor; Cell Movement; Cyclams; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; In Vitro Techniques; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Invasiveness; Prognosis; Receptors, CXCR4; Survival Rate; Xenograft Model Antitumor Assays | 2015 |
Mesenchymal stem cells as active prohealing and immunosuppressive agents in periapical environment: evidence from human and experimental periapical lesions.
Topics: 5'-Nucleotidase; Activated-Leukocyte Cell Adhesion Molecule; Adult; Animals; Antigens, Surface; Benzylamines; Biomarkers; CD146 Antigen; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Homeodomain Proteins; Humans; Immunosuppressive Agents; Integrin beta1; Interferon-gamma; Interleukin-17; Interleukin-1beta; Mesenchymal Stem Cells; Mice; Middle Aged; Periapical Granuloma; Periapical Tissue; RANK Ligand; Receptors, CXCR4; Thy-1 Antigens; Tumor Necrosis Factor-alpha; Wound Healing | 2014 |
Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model.
Topics: Animals; Antigens, Differentiation; Benzylamines; beta-Thalassemia; Cell Cycle; Cell Survival; Combined Modality Therapy; Cyclams; Disease Models, Animal; Genes, Reporter; Genetic Vectors; Graft Survival; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Heterocyclic Compounds; Lentivirus; Mice; Mice, Mutant Strains; Radiation Chimera; Recombinant Proteins; Splenectomy; Transplantation Chimera | 2014 |
Protein z exerts pro-angiogenic effects and upregulates CXCR4.
Topics: Adenoviridae; Animals; Benzylamines; Blood Proteins; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Genetic Vectors; Heterocyclic Compounds; Hindlimb; Human Umbilical Vein Endothelial Cells; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Receptors, CXCR4; RNA Interference; RNA, Small Interfering; Up-Regulation | 2014 |
Endogenous cell therapy improves bone healing.
Topics: Animals; Benzylamines; Bone Regeneration; Cell Adhesion; Cell Movement; Cell- and Tissue-Based Therapy; Cyclams; Disease Models, Animal; Flow Cytometry; Heterocyclic Compounds; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Parathyroid Hormone; Parietal Bone; Recombinant Proteins; Stem Cells; Wound Healing | 2015 |
Meningeal cells influence midbrain development and the engraftment of dopamine progenitors in Parkinsonian mice.
Topics: Adrenergic Agents; Animals; Benzylamines; Cell Differentiation; Cells, Cultured; Cyclams; Disease Models, Animal; Dopamine; Embryo, Mammalian; Embryonic Stem Cells; Female; Heterocyclic Compounds; Meninges; Mesencephalon; Mice; Mice, Transgenic; Neurons; Oxidopamine; Parkinsonian Disorders; Receptors, CXCR4; Stem Cell Transplantation; Tubulin; Tyrosine 3-Monooxygenase | 2015 |
CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice.
Topics: Adoptive Transfer; Animals; Benzylamines; Cell Proliferation; Cells, Cultured; Chemokine CXCL12; Cyclams; Disease Models, Animal; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hepatocytes; Heterocyclic Compounds; Leukocyte Common Antigens; Leukocytes, Mononuclear; Liver; Liver Diseases; Liver Regeneration; Male; Mice, Inbred C57BL; Receptors, CXCR4; Reperfusion Injury; Signal Transduction; Time Factors | 2015 |
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; Carrier Proteins; Cell Line, Tumor; Chromones; Cullin Proteins; Cyclams; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Heterocyclic Compounds; Humans; Huntington Disease; Kruppel-Like Transcription Factors; Mice; Morpholines; Phagosomes; Phosphatidylinositol Phosphates; Promyelocytic Leukemia Zinc Finger Protein; Proteasome Endopeptidase Complex; Proteolysis; Psychomotor Performance; Receptors, CXCR4; Rotarod Performance Test; Signal Transduction; Survival Analysis; Ubiquitination; Vesicular Transport Proteins | 2015 |
CXCR4 blockade attenuates hyperoxia-induced lung injury in neonatal rats.
Topics: Animals; Animals, Newborn; Benzylamines; Bronchopulmonary Dysplasia; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperoxia; Hypertension, Pulmonary; Inflammation; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, CXCR4 | 2015 |
Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke.
Topics: Animals; Benzylamines; Brain Infarction; Calcium-Binding Proteins; Cyclams; Cytokines; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Microscopy, Confocal; Nervous System Diseases; Neuroprotective Agents; Photons; Receptors, Interleukin-8A; Recovery of Function; Stroke | 2015 |
CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Benzylamines; Blotting, Western; Bone Neoplasms; Cell Adhesion; Cell Movement; Chemokine CXCL12; Coculture Techniques; Cyclams; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heterocyclic Compounds; Heterografts; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Male; Mice; Mice, Nude; Peptides; Prostatic Neoplasms; Receptors, CXCR4; Tomography, X-Ray Computed; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2015 |
CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzylamines; Biphenyl Compounds; Bone Marrow Transplantation; Chemokine CXCL12; Cyclams; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Ventricles; Hemodynamics; Heterocyclic Compounds; Humans; Mice; Mice, Transgenic; Myofibroblasts; Receptors, CXCR4; Tetrazoles | 2015 |
CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzylamines; Bronchi; Cell Line; Chemokine CXCL12; Cyclams; Disease Models, Animal; Down-Regulation; Enzyme Activation; Epithelial Cells; Female; Heterocyclic Compounds; Humans; Interleukin-13; Matrix Metalloproteinase 9; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovalbumin; Pneumonia; Receptors, CXCR4; Signal Transduction; Time Factors | 2015 |
CXCR4 antagonist AMD3100 reverses the neurogenesis and behavioral recovery promoted by forced limb-use in stroke rats.
Topics: Animals; Benzylamines; Brain; Brain Ischemia; Central Nervous System Agents; Chemokine CXCL12; Cyclams; Disease Models, Animal; Doublecortin Protein; Endothelin-1; Forelimb; Heterocyclic Compounds; Immobilization; Male; Maze Learning; Motor Activity; Musculoskeletal Manipulations; Neurogenesis; Neurons; Random Allocation; Rats, Wistar; Receptors, CXCR4; Recovery of Function; Stroke; Stroke Rehabilitation | 2015 |
AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis.
Topics: Animals; Benzylamines; Cartilage; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Rats; Rats, Wistar; Receptors, CXCR4; Sodium Acetate; Temporomandibular Joint Disorders | 2016 |
No evidence for cell activation or brain vaso-occlusion with plerixafor mobilization in sickle cell mice.
Topics: Anemia, Sickle Cell; Animals; Benzylamines; Bone Marrow; Cerebrovascular Disorders; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Gene Expression; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterocyclic Compounds; Humans; Injections, Subcutaneous; Male; Mice; Mice, Transgenic; Protein Binding; Receptors, CXCR4 | 2016 |
Strategies to target long-lived plasma cells for treating hemophilia A inhibitors.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Benzylamines; Cyclams; Disease Models, Animal; Enzyme-Linked Immunospot Assay; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Hemophilia A; Heterocyclic Compounds; Immune Tolerance; Immunosuppressive Agents; Mice; Plasma Cells; Receptors, CXCR4 | 2016 |
Symptomatic Improvement in Human Papillomavirus-Induced Epithelial Neoplasia by Specific Targeting of the CXCR4 Chemokine Receptor.
Topics: Animals; Apoptosis; Benzylamines; Cell Proliferation; Cells, Cultured; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Humans; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Papillomaviridae; Papillomavirus Infections; Random Allocation; Receptors, CXCR4; Skin Neoplasms | 2016 |
Role of monocyte chemoattractant protein-1, stromal derived factor-1 and retinoic acid in pathophysiology of neuropathic pain in rats.
Topics: Animals; Benzylamines; Chemokine CCL2; Chemokine CXCL12; Cyclams; Disease Models, Animal; Doxycycline; Female; Heterocyclic Compounds; Hyperalgesia; Neuralgia; Nociception; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sciatic Nerve; Tretinoin | 2016 |
Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain.
Topics: Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Injections, Spinal; Ischemia; Ligation; Lumbar Vertebrae; Male; Mice, Inbred C57BL; Microglia; Models, Biological; Motor Activity; Neuralgia; Nociception; Pyridines; Rats; Receptors, CXCR4; Sciatic Nerve | 2016 |
Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation.
Topics: Analgesics, Opioid; Animals; Benzylamines; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Ligation; Male; Narcotic Antagonists; Neuralgia; Rats, Sprague-Dawley; Receptors, CXCR4; Spinal Cord; Spinal Nerves | 2016 |
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Topics: Animals; Benzylamines; Biomarkers; Cachexia; Chemokine CXCL12; Cyclams; Cytokines; Disease Models, Animal; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; Indoles; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Neoplasms; Pyrroles; Rats; Receptors, CXCR4; Signal Transduction; Sunitinib | 2016 |
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyclams; Disease Models, Animal; Disease Progression; Hepatic Stellate Cells; Heterocyclic Compounds; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Nanoparticles; Neovascularization, Pathologic; Receptors, CXCR4; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Chronic administration of AMD3100 increases survival and alleviates pathology in SOD1(G93A) mice model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzylamines; Calcium-Binding Proteins; Chemokine CCL2; Claudin-5; Cyclams; Cytokines; Disease Models, Animal; Gene Expression Regulation; Heterocyclic Compounds; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Motor Neurons; Muscle Strength; Psychomotor Disorders; Receptors, CXCR4; Superoxide Dismutase; Zonula Occludens-1 Protein | 2016 |
Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis.
Topics: Animals; Benzylamines; Biomarkers; Bone and Bones; Bone Remodeling; Bone Resorption; Cartilage, Articular; Cell Differentiation; Chemokine CXCL12; Cyclams; Disease Models, Animal; Gene Expression; Heterocyclic Compounds; Male; Mice; Osteoarthritis; Osteoclasts; Receptors, CXCR4; Signal Transduction; Wounds and Injuries; X-Ray Microtomography | 2016 |
Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy.
Topics: Albuminuria; Animals; Benzylamines; Chemokine CXCL12; Cyclams; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Fibrosis; Glomerular Filtration Rate; Glucagon-Like Peptide-1 Receptor; Heterocyclic Compounds; Humans; Hypoglycemic Agents; Kidney; Linagliptin; Liraglutide; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Receptors, CXCR4; Up-Regulation | 2016 |
Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis.
Topics: Animals; Benzylamines; Bone Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Cyclams; Disease Models, Animal; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Heterocyclic Compounds; Humans; Male; Membrane Microdomains; Mice; Phosphorylation; Prostatic Neoplasms; Receptor, ErbB-2; Receptors, CXCR4; Signal Transduction; src-Family Kinases; Xenograft Model Antitumor Assays | 2016 |
CXC Chemokine Receptor 4 (CXCR4) Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.
Topics: Allografts; Animals; Benzylamines; Creatinine; Cyclams; Disease Models, Animal; Graft Survival; Heterocyclic Compounds; Kidney; Kidney Diseases; Kidney Transplantation; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, CXCR4 | 2016 |
C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury.
Topics: Advanced Oxidation Protein Products; Animals; Benzylamines; Biopsy; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclams; Disease Models, Animal; Doxorubicin; Heterocyclic Compounds; Humans; Mice; Oxidative Stress; Podocytes; Proteinuria; Receptors, CXCR4 | 2017 |
Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats.
Topics: Animals; Animals, Newborn; Anti-HIV Agents; Benzylamines; Brain Infarction; Cell Hypoxia; Cell Movement; Cell Polarity; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cyclams; Cytokines; Disease Models, Animal; Heterocyclic Compounds; Infarction, Middle Cerebral Artery; Male; Microglia; Neurons; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 2017 |
CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Benzylamines; Chemokine CXCL12; Cognition Disorders; Cyclams; Disease Models, Animal; Epilepsy, Temporal Lobe; Heterocyclic Compounds; Hippocampus; Housing, Animal; Kainic Acid; Male; Neurogenesis; Neurons; Random Allocation; Rats, Wistar; Receptors, CXCR4; Seizures | 2017 |
AMD3100 inhibits the migration and differentiation of neural stem cells after spinal cord injury.
Topics: Animals; Benzylamines; beta Catenin; Cell Differentiation; Cell Line; Cell Movement; Cell Proliferation; Cyclams; Disease Models, Animal; Down-Regulation; Heterocyclic Compounds; Locomotion; Male; Nestin; Neural Stem Cells; Neurons; Rats; Receptors, CXCR4; Signal Transduction; Spinal Cord Injuries | 2017 |
CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis.
Topics: Acute Disease; Animals; Anti-HIV Agents; Benzylamines; Blood-Brain Barrier; CD8-Positive T-Lymphocytes; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Humans; Male; Mice; Receptors, CXCR4; West Nile Fever; West Nile virus | 2008 |
Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis.
Topics: Animals; Benzylamines; Chemokine CXCL12; Cyclams; Cyclophosphamide; Cystitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Heterocyclic Compounds; Immunohistochemistry; Rats; Rats, Wistar; Receptors, CXCR; Receptors, CXCR4; Reflex, Abnormal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Urinary Bladder; Urination; Urothelium | 2010 |
Evaluation of CXCR4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization.
Topics: Actins; Animals; Benzylamines; Bruch Membrane; Capillary Permeability; Choroidal Neovascularization; Cyclams; Disease Models, Animal; Female; Flow Cytometry; Fluorescein Angiography; Heterocyclic Compounds; Indoles; Laser Coagulation; Leukocyte Count; Leukocytosis; Morpholines; Rats; Rats, Inbred BN; Receptor Protein-Tyrosine Kinases; Receptors, CXCR4; Wet Macular Degeneration | 2010 |
Endothelial progenitor cell transplantation improves long-term stroke outcome in mice.
Topics: Analysis of Variance; Animals; Antigens, CD34; Behavior, Animal; Benzylamines; Cadherins; Capillaries; CD11b Antigen; Cerebral Infarction; Chemokine CXCL12; Cyclams; Disease Models, Animal; Endothelial Cells; Endothelium; Flow Cytometry; Gene Expression Regulation; Heterocyclic Compounds; Humans; Infarction, Middle Cerebral Artery; Injections, Intravenous; Magnetic Resonance Imaging; Mice; Mice, Nude; Motor Activity; Neovascularization, Physiologic; Psychomotor Performance; Receptors, CXCR4; Stem Cell Transplantation; Time Factors; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2010 |
Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs.
Topics: Androstadienes; Animals; Benzylamines; Capillaries; Cyclams; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Erythropoietin; Femoral Artery; Heterocyclic Compounds; Hindlimb; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Ligation; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phlebotomy; Proto-Oncogene Proteins c-akt; Receptors, CXCR4; Regional Blood Flow; Signal Transduction; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A; Wortmannin | 2010 |
Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model.
Topics: Abietanes; Animals; Benzylamines; Bone Marrow Cells; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heterocyclic Compounds; Male; Mesenchymal Stem Cells; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phytotherapy; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Salvia miltiorrhiza; Stem Cell Transplantation; Up-Regulation | 2011 |
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.
Topics: Animals; Benzylamines; Blood Pressure; Bone Marrow Cells; Bone Marrow Transplantation; Cell Movement; Cyclams; Disease Models, Animal; Electroporation; Green Fluorescent Proteins; Heterocyclic Compounds; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, CXCR4; RNA Interference; Stem Cells; Transfection | 2011 |
Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Animals; Benzylamines; Bone Marrow Cells; Brain; Chemokine CXCL12; Chemotaxis; Cyclams; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterocyclic Compounds; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2011 |
Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization.
Topics: Animals; Benzylamines; Cell Movement; Cyclams; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Hedgehog Proteins; Heterocyclic Compounds; Humans; Injections, Intralesional; Injections, Subcutaneous; Mice; Mice, Knockout; Myocardial Infarction; Neovascularization, Physiologic; Random Allocation; Sensitivity and Specificity; Stem Cells; Survival Rate; Treatment Outcome; Ventricular Remodeling | 2011 |
Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis.
Topics: Animals; Benzylamines; Bone Regeneration; Bone Remodeling; Cell Count; Cyclams; Disease Models, Animal; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Osteoblasts; Osteogenesis; Parietal Bone; Receptors, CXCR4; Stem Cells; X-Ray Microtomography | 2011 |
Augmenting neovascularization accelerates distraction osteogenesis.
Topics: Absorptiometry, Photon; Animals; Benzylamines; Bone Morphogenetic Protein 2; Bone Regeneration; Cyclams; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Immunohistochemistry; Mandible; Neovascularization, Physiologic; Osteogenesis, Distraction; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; X-Ray Microtomography | 2011 |
Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord.
Topics: Animals; Benzylamines; Cell Movement; Cells, Cultured; Chemokine CXCL12; Cyclams; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Transgenic; Monocytes; RNA, Messenger; Spinal Cord Injuries; Sulfones; Time Factors | 2011 |
Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect.
Topics: Adipogenesis; Animals; Benzylamines; Blotting, Western; Bone and Bones; Bone Density; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cell Separation; Colony-Forming Units Assay; Cyclams; Disease Models, Animal; Fractures, Bone; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Insulin-Like Growth Factor I; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Receptors, CXCR4; Signal Transduction; Stem Cell Transplantation; Wound Healing; X-Ray Microtomography | 2012 |
[Anti-angiogenesis effect of AMD3100 in oxygen-induced retinopathy mice].
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Benzylamines; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperoxia; Mice; Mice, Inbred C57BL; Oxygen; Retinal Diseases; Retinal Neovascularization; Vascular Endothelial Growth Factor A | 2012 |
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Benzylamines; Chromones; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Indoles; Male; Paclitaxel; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Signal Transduction; Time Factors; Treatment Outcome | 2012 |
CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-HIV Agents; Apoptosis; Benzylamines; Chemokine CXCL12; Child, Preschool; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Humans; Leukemia, Myeloid, Acute; Male; Mice; Middle Aged; Receptors, CXCR4; Transplantation, Heterologous; Tumor Cells, Cultured | 2012 |
Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering.
Topics: Animals; Atherosclerosis; Benzylamines; Bone Marrow Cells; Cells, Cultured; Cyclams; Disease Models, Animal; Endothelial Cells; Female; Hematopoietic Stem Cell Mobilization; Heterocyclic Compounds; Hypercholesterolemia; Lipids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Plaque, Atherosclerotic; Stem Cell Transplantation; Stem Cells; Vasodilation | 2012 |
Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer.
Topics: Animals; Antibodies, Monoclonal, Humanized; Benzylamines; Body Weight; Bone Marrow; Cell Line, Tumor; Cell Movement; Cyclams; Disease Models, Animal; Esophageal Neoplasms; Female; Heterocyclic Compounds; Humans; Male; Mice; Neoplasm Metastasis; Receptor, ErbB-2; Receptors, CXCR4; Reproducibility of Results; Trastuzumab; Tumor Burden; Up-Regulation | 2012 |
Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Bacterial Load; Bacteroidaceae Infections; Benzylamines; Cyclams; Disease Models, Animal; Disease Progression; Heterocyclic Compounds; Infusion Pumps, Implantable; Mice; Mice, Inbred BALB C; Periodontitis; Porphyromonas gingivalis; Real-Time Polymerase Chain Reaction; Receptors, CXCR4 | 2012 |
CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.
Topics: Animals; Benzylamines; Bone Marrow Transplantation; Cardiotonic Agents; Cyclams; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Receptors, CXCR4; Recovery of Function; Signal Transduction | 2013 |
CXCR4 regulates growth of both primary and metastatic breast cancer.
Topics: Animals; Benzylamines; Cell Growth Processes; Cell Line, Tumor; Cyclams; Disease Models, Animal; Female; Heterocyclic Compounds; Lung Neoplasms; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Knockout; Neoplasm Metastasis; Neoplasm Transplantation; Receptors, CXCR4; RNA Interference; Transfection | 2004 |
Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis.
Topics: Animals; Antibody Formation; Arthritis, Experimental; Benzylamines; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chickens; Collagen Type II; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Immunity, Cellular; Interleukin-6; Joints; Male; Mice; Mice, Inbred DBA; Receptors, CXCR4 | 2005 |
Antagonism of stromal cell-derived factor-1alpha reduces infarct size and improves ventricular function after myocardial infarction.
Topics: Animals; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hypertrophy, Left Ventricular; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; RNA, Messenger; Ventricular Dysfunction, Left; Ventricular Remodeling | 2007 |
Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzylamines; Biomarkers; Brain; Chemokine CXCL12; Cyclams; Disease Models, Animal; Down-Regulation; Encephalitis; Gene Expression Regulation; Heterocyclic Compounds; Hippocampus; Humans; Learning Disabilities; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Receptors, CXCR4; RNA, Messenger; Synaptic Transmission | 2007 |
CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes.
Topics: AIDS Dementia Complex; Animals; Astrocytes; Benzylamines; Cats; Cells, Cultured; Chemokine CXCL12; Chemokines, CXC; Cyclams; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Products, gag; Heterocyclic Compounds; Immunodeficiency Virus, Feline; Microglia; Nerve Tissue Proteins; Receptors, CXCR4; Receptors, Virus; RNA, Messenger; Specific Pathogen-Free Organisms | 2001 |