Compounds > plerixafor
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plerixafor and Astrocytoma, Grade IV

plerixafor has been researched along with Astrocytoma, Grade IV in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (22.22)29.6817
2010's11 (61.11)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Ackermann, R; Alghamri, MS; Andjelkovic, AV; Apfelbaum, AA; Appelman, H; Banerjee, K; Barissi, M; Calinescu, A; Candolfi, M; Carney, S; Castro, MG; Comba, A; Edwards, MB; Faisal, SM; Gan, J; Gregory, JV; Jiménez, JA; Kadiyala, P; Lahann, J; Lawlor, ER; Lowenstein, PR; Martinez-Revollar, G; Mauser, A; McClellan, BL; Mujeeb, AA; Olin, MR; Schwendeman, A; Stamatovic, SM; Sun, Y; Taher, A; Thalla, R; Varela, ML1
Ball, R; Bertrand, S; Born, D; Brown, JM; Iv, M; Lavezo, J; Nagpal, S; Pelpola, JS; Recht, LD; Soltys, SG; Sundaram, V; Thomas, RP; Vogel, H; Yang, J1
Cheng, L; Dai, L; Deng, H; Deng, J; Fan, P; Gong, Q; Hu, X; Li, C; Lin, Y; Liu, Y; Luo, Q; Shi, G; Su, X; Wang, Q; Xie, Q; Yang, Y; Yu, D; Zhang, H; Zhang, S; Zhang, X; Zheng, L1
Cavallini, C; Cerofolini, L; D'Amore, VM; Daniele, S; Fragai, M; Giuntini, S; La Pietra, V; La Regina, G; Luchinat, C; Marinelli, L; Martini, C; Nalli, M; Novellino, E; Pedrini, M; Piccarducci, R; Pietrobono, D; Puxeddu, M; Russomanno, P; Silvestri, R; Taliani, S1
Gao, G; Jiang, Z; Li, X; Xu, Y; Zhou, W1
Amoureux, MC; Debarbieux, F; Ricard, C; Rodriguez, T; Rougon, G; Stanchi, F1
Bajetto, A; Barbieri, F; Daga, A; Fiaschi, P; Florio, T; Gatti, M; Pattarozzi, A; Würth, R; Zona, G1
Dedobbeleer, M; Denne, A; Di Valentin, E; Goffart, N; Kroonen, J; Martinive, P; Rogister, B1
Foltz, G; Harrison, JK; Hothi, P; Law, BK; Luo, D; Pham, K; Reynolds, BA; Siemann, DW1
Boucard, C; Chinot, O; Delfino, C; Denicolai, E; Figarella-Branger, D; Graillon, T; Metellus, P; Nanni, I; Ouafik, L; Padovani, L; Tabouret, E; Tchoghandjian, A1
Cobb, WS; Greenfield, JP; Lyden, D1
Brown, JM; Harsh, GR; Hoffman, RM; Kioi, M; Schultz, G; Vogel, H1
Kast, RE1
Arakawa, F; Ohshima, K; Okada, Y; Shigemori, M; Sugita, Y; Terasaki, M1
Chan, JA; Kieran, MW; Klein, RS; Kung, AL; Luster, AD; Rubin, JB; Schmidt, K; Segal, RA; Sun, Y1
Sarkar, S; Yong, VW; Zhang, J1
Chan, JA; Kung, AL; Redjal, N; Segal, RA1
Bergers, G; Du, R; Ganss, R; Johnson, RS; Liu, P; Lu, KV; Passegué, E; Petritsch, C; Song, H; Vandenberg, S; Werb, Z1

Reviews

1 review(s) available for plerixafor and Astrocytoma, Grade IV

ArticleYear
CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target.
    Brain tumor pathology, 2011, Volume: 28, Issue:2

    Topics: Benzylamines; Brain Neoplasms; Cell Movement; Chemokine CXCL12; Cyclams; Glioblastoma; Heterocyclic Compounds; Humans; Lymphoma; Neoplasm Metastasis; Protein Binding; Receptors, CXCR4; Signal Transduction; Stem Cells

2011

Trials

1 trial(s) available for plerixafor and Astrocytoma, Grade IV

ArticleYear
Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 12-01, Volume: 25, Issue:23

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Benzylamines; Brain Neoplasms; Chemoradiotherapy; Cyclams; Female; Follow-Up Studies; Glioblastoma; Heterocyclic Compounds; Humans; Macrophages; Male; Middle Aged; Prognosis; Receptors, CXCR4; Survival Rate; Young Adult

2019

Other Studies

16 other study(ies) available for plerixafor and Astrocytoma, Grade IV

ArticleYear
Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy.
    ACS nano, 2022, 06-28, Volume: 16, Issue:6

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL12; Glioblastoma; Glioma; Humans; Immunotherapy; Mice; Nanoparticles; Receptors, CXCR4; Signal Transduction; Tumor Microenvironment

2022
BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
    Oncogene, 2021, Volume: 40, Issue:8

    Topics: Adult; Aged; Animals; Basic-Leucine Zipper Transcription Factors; Benzylamines; Cell Line, Tumor; Cell Migration Inhibition; Chemokine CXCL12; Cyclams; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Heterografts; Humans; Male; Mice; Middle Aged; Myeloid-Derived Suppressor Cells; Neoplasm Staging; Receptors, CXCR4; Signal Transduction; Tumor Microenvironment; Tumor Suppressor Proteins; Young Adult

2021
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme.
    European journal of pharmacology, 2021, Apr-15, Volume: 897

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzylamines; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclams; Drug Synergism; Glioblastoma; Humans; Indoles; Neoplasm Invasiveness; Neoplastic Stem Cells; Neurogenesis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Receptors, CXCR4; Signal Transduction; Spheroids, Cellular; Tumor Suppressor Protein p53

2021
Irradiated normal brain promotes invasion of glioblastoma through vascular endothelial growth and stromal cell-derived factor 1α.
    Neuroreport, 2013, Sep-11, Volume: 24, Issue:13

    Topics: Animals; Benzylamines; Brain; Brain Chemistry; Brain Neoplasms; Chemokine CXCL12; Cyclams; Cytokines; Gamma Rays; Glioblastoma; Heterocyclic Compounds; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Vascular Endothelial Growth Factor A

2013
Dynamic quantitative intravital imaging of glioblastoma progression reveals a lack of correlation between tumor growth and blood vessel density.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Antibodies, Monoclonal, Humanized; Benzylamines; Bevacizumab; Cell Line, Tumor; Cyclams; Glioblastoma; Heterocyclic Compounds; Humans; Male; Mice; Mice, Nude; Receptors, CXCR4; Vascular Endothelial Growth Factor A

2013
Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity.
    Toxicology, 2013, Dec-15, Volume: 314, Issue:2-3

    Topics: Animals; Autocrine Communication; Benzylamines; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemokine CXCL12; Cyclams; Down-Regulation; Glioblastoma; Heterocyclic Compounds; Humans; Mice, SCID; Neoplastic Stem Cells; Paracrine Communication; Receptors, CXCR4

2013
Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling.
    Neuro-oncology, 2015, Volume: 17, Issue:1

    Topics: Animals; Benzylamines; Brain Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Cyclams; Disease Models, Animal; Female; Glioblastoma; Heterocyclic Compounds; Humans; Lateral Ventricles; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Receptors, CXCR4; Signal Transduction

2015
VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner.
    Cancer letters, 2015, Apr-28, Volume: 360, Issue:1

    Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Benzylamines; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cyclams; Female; Glioblastoma; Heterocyclic Compounds; Humans; Interleukin-2 Receptor alpha Subunit; Male; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; Neoplasm Invasiveness; Piperidines; Protein Kinase Inhibitors; Quinazolines; Receptor Cross-Talk; Receptors, CXCR4; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; Up-Regulation; Xenograft Model Antitumor Assays

2015
Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway.
    Oncotarget, 2015, May-10, Volume: 6, Issue:13

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Benzylamines; Brain Neoplasms; Chemokine CXCL12; Chemoradiotherapy; Child; Child, Preschool; Cyclams; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Gene Expression Profiling; Glioblastoma; Heterocyclic Compounds; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Retrospective Studies; Signal Transduction; Temozolomide; Time Factors; Tissue Culture Techniques; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-2; Young Adult

2015
Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:3

    Topics: Animals; Anti-HIV Agents; Antibodies, Neutralizing; Antineoplastic Agents; Benzylamines; Bone Marrow Cells; Brain Neoplasms; CD11b Antigen; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Cyclams; Glioblastoma; Heterocyclic Compounds; Humans; Hypoxia-Inducible Factor 1; Mice; Mice, Nude; Monocytes; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neovascularization, Pathologic; Receptors, CXCR4; Transplantation, Heterologous; Whole-Body Irradiation

2010
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:3

    Topics: Animals; Anti-HIV Agents; Antibodies, Neutralizing; Antineoplastic Agents; Benzylamines; Bone Marrow Cells; Brain Neoplasms; CD11b Antigen; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Cyclams; Glioblastoma; Heterocyclic Compounds; Humans; Hypoxia-Inducible Factor 1; Mice; Mice, Nude; Monocytes; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neovascularization, Pathologic; Receptors, CXCR4; Transplantation, Heterologous; Whole-Body Irradiation

2010
Profound blockage of CXCR4 signaling at multiple points using the synergy between plerixafor, mirtazapine, and clotrimazole as a new glioblastoma treatment adjunct.
    Turkish neurosurgery, 2010, Volume: 20, Issue:4

    Topics: Antifungal Agents; Benzylamines; Brain Neoplasms; Clotrimazole; Cyclams; Drug Synergism; Glioblastoma; Heterocyclic Compounds; Histamine H1 Antagonists; Humans; Mianserin; Mirtazapine; Receptors, CXCR4; Signal Transduction

2010
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-11, Volume: 100, Issue:23

    Topics: Animals; Anti-HIV Agents; Apoptosis; Benzylamines; Brain Neoplasms; Cell Division; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Cyclams; Glioblastoma; Heterocyclic Compounds; Humans; In Situ Nick-End Labeling; Luciferases; Magnetic Resonance Imaging; Medulloblastoma; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, CXCR4; Time Factors

2003
The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase.
    Carcinogenesis, 2005, Volume: 26, Issue:12

    Topics: Animals; Anti-HIV Agents; Benzylamines; Blotting, Western; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Collagen; Cyclams; Drug Combinations; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Heterocyclic Compounds; Humans; Laminin; Matrix Metalloproteinase 15; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Proteoglycans; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tumor Cells, Cultured

2005
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Nov-15, Volume: 12, Issue:22

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzylamines; Brain Neoplasms; Carmustine; Cell Proliferation; Cyclams; Drug Synergism; Glioblastoma; Glioma; Heterocyclic Compounds; Humans; Mice; Mice, Nude; Receptors, CXCR4; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2006
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
    Cancer cell, 2008, Volume: 13, Issue:3

    Topics: Animals; Antigens, Differentiation; Benzylamines; Bone Marrow Cells; Bone Marrow Transplantation; Brain Neoplasms; Cell Hypoxia; Cell Line; Cell Movement; Chemokine CXCL12; Cyclams; Endothelial Cells; Glioblastoma; Heterocyclic Compounds; Hypoxia-Inducible Factor 1, alpha Subunit; Leukocyte Common Antigens; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Monocytes; Neoplasm Invasiveness; Neovascularization, Pathologic; Pericytes; Receptor, TIE-2; Receptors, CXCR4; Signal Transduction; Transduction, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2008