pleconaril has been researched along with Enterovirus Infections in 37 studies
WIN 63843: structure given in first source
Enterovirus Infections: Diseases caused by ENTEROVIRUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with severe combined immunodeficiency and enterovirus infections were successfully treated with pleconaril." | 7.71 | Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency. ( Forman, MS; Lederman, HM; Nowak-Wegrzyn, A; Phipatanakul, W; Winkelstein, JA, 2001) |
| "Pleconaril is a novel compound that integrates into the capsid of picornaviruses, including enteroviruses and rhinoviruses, preventing the virus from attaching to cellular receptors and uncoating to release RNA into the cell." | 6.70 | Treatment of potentially life-threatening enterovirus infections with pleconaril. ( Rotbart, HA; Webster, AD, 2001) |
| " Investigational agents such as the capsid inhibitors pleconaril and pocapavir show promise for treatment of neonatal enterovirus infections, and other investigational agents are being developed." | 4.98 | Neonatal nonpolio enterovirus and parechovirus infections. ( DeBiasi, RL; Harik, N, 2018) |
| "Two patients with severe combined immunodeficiency and enterovirus infections were successfully treated with pleconaril." | 3.71 | Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency. ( Forman, MS; Lederman, HM; Nowak-Wegrzyn, A; Phipatanakul, W; Winkelstein, JA, 2001) |
| "Pleconaril was well-tolerated, although twice as many adverse events occurred per subject in the pleconaril group." | 2.71 | Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. ( Abzug, MJ; Blount, S; Bradley, J; Capparelli, EV; Cloud, G; Kimberlin, DW; Lakeman, F; Lepow, M; Mani, C; Powell, D; Romero, J; Sánchez, PJ; Whitley, RJ, 2003) |
| "Pleconaril is a novel compound that integrates into the capsid of picornaviruses, including enteroviruses and rhinoviruses, preventing the virus from attaching to cellular receptors and uncoating to release RNA into the cell." | 2.70 | Treatment of potentially life-threatening enterovirus infections with pleconaril. ( Rotbart, HA; Webster, AD, 2001) |
| "Pleconaril is an orally active, broad spectrum antipicornaviral agent with activity against nonpolio enteroviruses." | 2.69 | Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network. ( Abdel-Rahman, SM; Bradley, JS; Capparelli, EV; Jacobs, RF; James, LP; Johnson, KM; Kearns, GL, 2000) |
| "Pleconaril is an investigational agent that inhibits viral attachment to host cell receptors and uncoating of viral nucleic acid." | 2.42 | Presentation, diagnosis, and management of enterovirus infections in neonates. ( Abzug, MJ, 2004) |
| "New developments in rapid diagnosis of enterovirus infections using polymerase chain reaction (PCR) positively affect patient management and have the potential to reduce the healthcare impact of enterovirus infection." | 2.41 | Enterovirus infections: diagnosis and treatment. ( Sawyer, MH, 2002) |
| "Enterovirus infections are common in both children and adults and range from benign short-lived febrile illnesses to life-threatening infections." | 2.41 | Enterovirus infections: diagnosis and treatment. ( Sawyer, MH, 2001) |
| "Pleconaril is an antiviral agent with in vitro activity against HEVs that has been used in the treatment of HEV infections." | 1.38 | Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility. ( Benschop, KS; Koen, G; Kuijpers, TW; van den Broek, PJ; Vossen, AC; Wierenga, PC; Wildenbeest, JG; Wolthers, KC, 2012) |
| "Acute pulmonary edema and encephalomyelitis occurs with EV71 infection in infants." | 1.32 | Survival after pulmonary edema due to enterovirus 71 encephalitis. ( Andrews, PI; Bye, AM; Craig, ME; Lahra, MM; Nolan, MA; Prager, PC; Rawlinson, WD; Williams, GD, 2003) |
| "Pleconaril appears to be a promising drug for the treatment of enteroviral and rhinoviral infections." | 1.31 | Pleconaril: a novel antipicornaviral drug. ( Romero, JR, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 18 (48.65) | 29.6817 |
| 2010's | 14 (37.84) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar Biswas, B | 2 |
| Malpani, YR | 2 |
| Ha, N | 1 |
| Kwon, DH | 1 |
| Soo Shin, J | 2 |
| Kim, HS | 1 |
| Kim, C | 1 |
| Bong Han, S | 2 |
| Lee, CK | 1 |
| Jung, YS | 2 |
| Da Costa, L | 1 |
| Scheers, E | 1 |
| Coluccia, A | 1 |
| Casulli, A | 1 |
| Roche, M | 1 |
| Di Giorgio, C | 1 |
| Neyts, J | 3 |
| Terme, T | 1 |
| Cirilli, R | 1 |
| La Regina, G | 1 |
| Silvestri, R | 1 |
| Mirabelli, C | 2 |
| Vanelle, P | 1 |
| Hwang, D | 1 |
| Jung, E | 1 |
| Vishakantegowda, AG | 1 |
| Lane, TR | 1 |
| Fu, J | 1 |
| Sherry, B | 1 |
| Tarbet, B | 1 |
| Hurst, BL | 1 |
| Riabova, O | 1 |
| Kazakova, E | 1 |
| Egorova, A | 1 |
| Clarke, P | 1 |
| Leser, JS | 1 |
| Frost, J | 1 |
| Rudy, M | 1 |
| Tyler, KL | 1 |
| Klose, T | 1 |
| Volobueva, AS | 1 |
| Belyaevskaya, SV | 1 |
| Zarubaev, VV | 1 |
| Kuhn, RJ | 2 |
| Makarov, V | 1 |
| Ekins, S | 1 |
| Ma, Y | 1 |
| Abdelnabi, R | 1 |
| Delang, L | 2 |
| Froeyen, M | 2 |
| Luyten, W | 1 |
| Harik, N | 1 |
| DeBiasi, RL | 1 |
| Zhang, M | 1 |
| Zhang, Y | 2 |
| Wang, Y | 1 |
| Lv, W | 1 |
| Abzug, MJ | 4 |
| Liu, Y | 1 |
| Sheng, J | 1 |
| Fokine, A | 1 |
| Meng, G | 1 |
| Shin, WH | 1 |
| Long, F | 1 |
| Kihara, D | 1 |
| Rossmann, MG | 1 |
| Sun, L | 1 |
| Meijer, A | 1 |
| Zhang, L | 1 |
| Thibaut, HJ | 1 |
| Baggen, J | 1 |
| George, S | 1 |
| Vernachio, J | 1 |
| van Kuppeveld, FJ | 1 |
| Leyssen, P | 1 |
| Hilgenfeld, R | 1 |
| Michaels, MG | 1 |
| Wald, E | 1 |
| Jacobs, RF | 2 |
| Romero, JR | 2 |
| Sánchez, PJ | 2 |
| Wilson, G | 1 |
| Krogstad, P | 1 |
| Storch, GA | 1 |
| Lawrence, R | 1 |
| Shelton, M | 1 |
| Palmer, A | 1 |
| Robinson, J | 1 |
| Dennehy, P | 1 |
| Sood, SK | 1 |
| Cloud, G | 2 |
| Jester, P | 1 |
| Acosta, EP | 1 |
| Whitley, R | 1 |
| Kimberlin, D | 1 |
| Hernández, M | 1 |
| Muller, WJ | 1 |
| Schmidtke, M | 2 |
| Wutzler, P | 2 |
| Zieger, R | 1 |
| Riabova, OB | 2 |
| Makarov, VA | 2 |
| Ooi, MH | 1 |
| Wong, SC | 1 |
| Lewthwaite, P | 1 |
| Cardosa, MJ | 1 |
| Solomon, T | 1 |
| Zhang, G | 1 |
| Zhou, F | 1 |
| Gu, B | 1 |
| Ding, C | 1 |
| Feng, D | 1 |
| Xie, F | 1 |
| Wang, J | 1 |
| Zhang, C | 1 |
| Cao, Q | 1 |
| Deng, Y | 1 |
| Hu, W | 1 |
| Yao, K | 1 |
| Wildenbeest, JG | 1 |
| van den Broek, PJ | 1 |
| Benschop, KS | 1 |
| Koen, G | 1 |
| Wierenga, PC | 1 |
| Vossen, AC | 1 |
| Kuijpers, TW | 1 |
| Wolthers, KC | 1 |
| Sawyer, MH | 3 |
| Tormey, VJ | 1 |
| Buscombe, JR | 1 |
| Johnson, MA | 1 |
| Thomson, AP | 1 |
| Webster, AD | 3 |
| Bradley, J | 1 |
| Romero, J | 1 |
| Powell, D | 1 |
| Lepow, M | 1 |
| Mani, C | 1 |
| Capparelli, EV | 2 |
| Blount, S | 1 |
| Lakeman, F | 1 |
| Whitley, RJ | 2 |
| Kimberlin, DW | 1 |
| Nolan, MA | 1 |
| Craig, ME | 1 |
| Lahra, MM | 1 |
| Rawlinson, WD | 1 |
| Prager, PC | 1 |
| Williams, GD | 2 |
| Bye, AM | 1 |
| Andrews, PI | 1 |
| Prager, P | 1 |
| Nolan, M | 1 |
| Andrews, IP | 1 |
| Hammerschmidt, E | 1 |
| Schüler, S | 1 |
| Zell, R | 1 |
| Birch-Hirschfeld, E | 1 |
| Rentz, AC | 1 |
| Libbey, JE | 1 |
| Fujinami, RS | 1 |
| Whitby, FG | 1 |
| Byington, CL | 1 |
| Desmond, RA | 1 |
| Accortt, NA | 1 |
| Talley, L | 1 |
| Villano, SA | 1 |
| Soong, SJ | 1 |
| Rotbart, HA | 2 |
| Flückiger, U | 1 |
| Yarush, LI | 1 |
| Steele, RW | 1 |
| Kearns, GL | 1 |
| Bradley, JS | 1 |
| James, LP | 1 |
| Johnson, KM | 1 |
| Abdel-Rahman, SM | 1 |
| Nowak-Wegrzyn, A | 1 |
| Phipatanakul, W | 1 |
| Winkelstein, JA | 1 |
| Forman, MS | 1 |
| Lederman, HM | 1 |
| Nigrovic, LE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1 Study to Confirm the Single- and Multiple-dose Pharmacokinetics and to Evaluate Food Effect of Vapendavir in Healthy Participants and Participants With COPD[NCT05962645] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-05-19 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for pleconaril and Enterovirus Infections
| Article | Year |
|---|---|
Neonatal nonpolio enterovirus and parechovirus infections.
Topics: Antiviral Agents; Cross Infection; Enterovirus; Enterovirus Infections; Female; Fomites; Humans; Inf | 2018 |
The enteroviruses: problems in need of treatments.
Topics: Antiviral Agents; Drug Discovery; Enterovirus Infections; Global Health; Humans; Oxadiazoles; Oxazol | 2014 |
Treatment of perinatal viral infections to improve neurologic outcomes.
Topics: Acyclovir; Antiviral Agents; Brain; Cognition; Cognition Disorders; Encephalitis, Herpes Simplex; En | 2017 |
Clinical features, diagnosis, and management of enterovirus 71.
Topics: Disease Management; Enterovirus A, Human; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles | 2010 |
Enterovirus infections: diagnosis and treatment.
Topics: Adult; Antiviral Agents; Child; Clinical Trials as Topic; Enterovirus Infections; Humans; Meningitis | 2002 |
Presentation, diagnosis, and management of enterovirus infections in neonates.
Topics: Adult; Antiviral Agents; Child; Enterovirus Infections; Humans; Infant, Newborn; Oxadiazoles; Oxazol | 2004 |
Pleconaril--an advance in the treatment of enteroviral infection in immuno-compromised patients.
Topics: Antiviral Agents; Enterovirus Infections; Humans; Immunocompromised Host; Oxadiazoles; Oxazoles; Pol | 2005 |
Antiviral therapy for enteroviral infections.
Topics: Adult; Antiviral Agents; Enterovirus Infections; Humans; Immunization, Passive; Infant, Newborn; Oxa | 1999 |
Enterovirus infections: diagnosis and treatment.
Topics: Antiviral Agents; Child; Cost of Illness; Enterovirus; Enterovirus Infections; Humans; Meningitis, V | 1999 |
[On new antiviral drugs, new viruses and old known bacteria].
Topics: Anti-Bacterial Agents; Antiviral Agents; Bacteria; Bacterial Infections; Enterovirus; Enterovirus In | 1999 |
Enterovirus infections: diagnosis and treatment.
Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Enterovirus Infections; Female; Humans | 2001 |
What's new with enteroviral infections?
Topics: Antiviral Agents; Cost-Benefit Analysis; Disease Outbreaks; Enterovirus Infections; Humans; Oxadiazo | 2001 |
6 trials available for pleconaril and Enterovirus Infections
| Article | Year |
|---|---|
A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis.
Topics: Antiviral Agents; Double-Blind Method; Enterovirus; Enterovirus Infections; Female; Humans; Infant; | 2016 |
[A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis].
Topics: Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Humans; Infant, Newborn; Male | 2016 |
Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis.
Topics: Administration, Oral; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method | 2003 |
Enteroviral meningitis: natural history and outcome of pleconaril therapy.
Topics: Adult; Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Headache; Humans; Male | 2006 |
Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network.
Topics: Administration, Oral; Age Factors; Antiviral Agents; Area Under Curve; Biological Availability; Ente | 2000 |
Treatment of potentially life-threatening enterovirus infections with pleconaril.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Child; Child, Preschool; Chronic Disease; Enterovirus; En | 2001 |
19 other studies available for pleconaril and Enterovirus Infections
| Article | Year |
|---|---|
Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones.
Topics: Animals; Antiviral Agents; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Microsomes; Pyri | 2017 |
Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.
Topics: Animals; Antiviral Agents; Drug Design; Enterovirus Infections; HeLa Cells; Humans; Male; Micronucle | 2018 |
Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode.
Topics: Animals; Antiviral Agents; Capsid; Enterovirus; Enterovirus Infections; Purines; Rats; Rhinovirus; V | 2022 |
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5.
Topics: Animals; Antiviral Agents; Cryoelectron Microscopy; Enterovirus; Enterovirus B, Human; Enterovirus D | 2023 |
New class of early-stage enterovirus inhibitors with a novel mechanism of action.
Topics: Antiviral Agents; Capsid; Capsid Proteins; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, | 2017 |
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovi | 2019 |
Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Topics: Antiviral Agents; Capsid; Child; Crystallography, X-Ray; Enterovirus D, Human; Enterovirus Infection | 2015 |
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.
Topics: Antiviral Agents; Drug Resistance, Viral; Enterovirus D, Human; Enterovirus Infections; Humans; Micr | 2015 |
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.
Topics: Antiviral Agents; Drug Design; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; | 2009 |
In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection.
Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Cell Survival; Child, Preschool; Dise | 2012 |
Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility.
Topics: Antiviral Agents; Cerebrospinal Fluid; Child; Chronic Disease; Drug Resistance, Viral; Enterovirus; | 2012 |
SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis.
Topics: Adolescent; Adult; Antiviral Agents; Common Variable Immunodeficiency; Enterovirus; Enterovirus Infe | 2003 |
Survival after pulmonary edema due to enterovirus 71 encephalitis.
Topics: Acute Disease; Antiviral Agents; Child, Preschool; Combined Modality Therapy; Disease Outbreaks; Enc | 2003 |
Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors.
Topics: Antiviral Agents; Child, Preschool; Echocardiography; Encephalitis, Viral; Enterovirus; Enterovirus | 2003 |
Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment.
Topics: Amino Acid Substitution; Animals; Antiviral Agents; Capsid; Capsid Proteins; Cell Line; CHO Cells; C | 2005 |
Investigation of treatment failure in neonatal echovirus 7 infection.
Topics: Antiviral Agents; Enterovirus B, Human; Enterovirus Infections; Fatal Outcome; Female; Humans; Immun | 2006 |
Diagnosis and prospective treatment of enteroviral infections in children.
Topics: Antiviral Agents; Child; Diagnosis, Differential; Enterovirus Infections; Humans; Oxadiazoles; Oxazo | 2000 |
Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency.
Topics: Antiviral Agents; Enterovirus Infections; Feces; Female; Humans; Infant; Oxadiazoles; Oxazoles; Poly | 2001 |
Pleconaril: a novel antipicornaviral drug.
Topics: Antiviral Agents; Clinical Trials as Topic; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles | 2001 |