pleconaril has been researched along with Diabetes Mellitus, Type 1 in 5 studies
WIN 63843: structure given in first source
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Median effective dose was interpolated from the triplicated experiments and the dose-response curves were generated for each drug-virus combination." | 1.56 | A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. ( Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB, 2020) |
| "Pleconaril treatment reduced the beta-cells' insulin secretion in response to glucose stimulation in some experiments and induced slight morphological changes to the islets compared to untreated controls." | 1.34 | Antiviral treatment of Coxsackie B virus infection in human pancreatic islets. ( Berg, AK; Frisk, G; Korsgren, O; Olsson, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krogvold, L | 1 |
| Mynarek, IM | 1 |
| Ponzi, E | 1 |
| Mørk, FB | 1 |
| Hessel, TW | 1 |
| Roald, T | 1 |
| Lindblom, N | 1 |
| Westman, J | 1 |
| Barker, P | 1 |
| Hyöty, H | 2 |
| Ludvigsson, J | 1 |
| Hanssen, KF | 1 |
| Johannesen, J | 1 |
| Dahl-Jørgensen, K | 1 |
| Sioofy-Khojine, AB | 1 |
| Honkimaa, A | 1 |
| Niklasson, B | 2 |
| Klitz, W | 2 |
| Juntti-Berggren, L | 2 |
| Berggren, PO | 2 |
| Lindquist, L | 1 |
| Holmberg, R | 1 |
| Blixt, M | 1 |
| Berg, AK | 1 |
| Olsson, A | 1 |
| Korsgren, O | 1 |
| Frisk, G | 1 |
1 trial available for pleconaril and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial.
Topics: Adolescent; Antiviral Agents; C-Peptide; Child; Diabetes Mellitus, Type 1; Double-Blind Method; Huma | 2023 |
4 other studies available for pleconaril and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabe | 2020 |
Effectiveness of Antivirals in a Type 1 Diabetes Model and the Move Toward Human Trials.
Topics: Adult; Alkynes; Animals; Antiviral Agents; Benzoxazines; Cyclopropanes; Diabetes Mellitus, Type 1; H | 2020 |
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats.
Topics: Animals; Antibodies, Viral; Antiviral Agents; Diabetes Mellitus, Type 1; Drug Therapy, Combination; | 2009 |
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets.
Topics: Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Cytopathogenic Effect, Viral; Diabetes | 2007 |