pleconaril has been researched along with Coxsackie Virus Infections in 11 studies
WIN 63843: structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| " Median effective dose was interpolated from the triplicated experiments and the dose-response curves were generated for each drug-virus combination." | 1.56 | A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. ( Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB, 2020) |
| "Pleconaril treatment reduced the beta-cells' insulin secretion in response to glucose stimulation in some experiments and induced slight morphological changes to the islets compared to untreated controls." | 1.34 | Antiviral treatment of Coxsackie B virus infection in human pancreatic islets. ( Berg, AK; Frisk, G; Korsgren, O; Olsson, A, 2007) |
| "Treatment with pleconaril increased the survival rate in all three models for both prophylactic and therapeutic dosing regimens." | 1.30 | Activity of pleconaril against enteroviruses. ( Groarke, JM; Pevear, DC; Seipel, ME; Tull, TM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Sioofy-Khojine, AB | 1 |
| Honkimaa, A | 1 |
| Hyöty, H | 1 |
| Stoyanova, A | 3 |
| Galabov, AS | 3 |
| Nikolova, I | 2 |
| Martikainen, M | 1 |
| Salorinne, K | 1 |
| Lahtinen, T | 1 |
| Malola, S | 1 |
| Permi, P | 1 |
| Häkkinen, H | 1 |
| Marjomäki, V | 1 |
| Tang, S | 1 |
| Li, YH | 2 |
| Cheng, XY | 1 |
| Wang, HQ | 1 |
| Kong, LY | 1 |
| Zhang, X | 1 |
| Jiang, JD | 1 |
| Song, DQ | 1 |
| Pürstinger, G | 1 |
| Dobrikov, G | 1 |
| Dimitrov, V | 1 |
| Philipov, S | 1 |
| Bauer, S | 1 |
| Gottesman, G | 1 |
| Sirota, L | 1 |
| Litmanovitz, I | 1 |
| Ashkenazi, S | 1 |
| Levi, I | 1 |
| Bryant, PA | 1 |
| Tingay, D | 1 |
| Dargaville, PA | 1 |
| Starr, M | 1 |
| Curtis, N | 1 |
| Berg, AK | 1 |
| Olsson, A | 1 |
| Korsgren, O | 1 |
| Frisk, G | 1 |
| Pevear, DC | 1 |
| Tull, TM | 1 |
| Seipel, ME | 1 |
| Groarke, JM | 1 |
| Schiff, GM | 1 |
| Sherwood, JR | 1 |
2 trials available for pleconaril and Coxsackie Virus Infections
| Article | Year |
|---|---|
Severe Coxsackie virus B infection in preterm newborns treated with pleconaril.
Topics: Antiviral Agents; Coxsackievirus Infections; Diseases in Twins; Enterovirus B, Human; Female; Humans | 2002 |
Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection.
Topics: Adolescent; Adult; Antibodies, Viral; Antiviral Agents; Coxsackievirus Infections; Enterovirus; Fema | 2000 |
9 other studies available for pleconaril and Coxsackie Virus Infections
| Article | Year |
|---|---|
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabe | 2020 |
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3.
Topics: Animals; Antiviral Agents; Apomorphine; Cell Line; Coxsackievirus Infections; Disease Models, Animal | 2020 |
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Inf | 2015 |
Hydrophobic pocket targeting probes for enteroviruses.
Topics: Cell Line, Tumor; Coxsackievirus Infections; Enterovirus B, Human; Fluorescent Dyes; Gold; Humans; H | 2015 |
SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections | 2016 |
Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Cells, Cultured; Coxsackievirus Infections; Drug Resistance, | 2015 |
Neonatal coxsackie B virus infection-a treatable disease?
Topics: Antiviral Agents; Cardiomyopathies; Coxsackievirus Infections; Disseminated Intravascular Coagulatio | 2004 |
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets.
Topics: Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Cytopathogenic Effect, Viral; Diabetes | 2007 |
Activity of pleconaril against enteroviruses.
Topics: Animals; Animals, Newborn; Animals, Suckling; Antiviral Agents; Cells, Cultured; Coxsackievirus Infe | 1999 |