platensimycin has been researched along with Staphylococcal-Infections* in 3 studies
3 other study(ies) available for platensimycin and Staphylococcal-Infections
| Article | Year |
|---|---|
Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo.
Bacterial fatty acid synthases are promising antibacterial targets against multidrug-resistant pathogens. Platensimycin (PTM) is a potent FabB/FabF inhibitor, while its poor pharmacokinetics hampers the clinical development. In this study, a focused library of PTM derivatives was prepared through thiolysis of PTM oxirane ( Topics: Adamantane; Aminobenzoates; Anilides; Animals; Anti-Bacterial Agents; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Models, Molecular; Peritonitis; Small Molecule Libraries; Staphylococcal Infections; Staphylococcus | 2019 |
Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions.
Platensimycin (PTM), originally isolated from soil bacteria Streptomyces platensis, is a potent FabF inhibitor against many Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. However, the further clinical development of PTM is hampered by its poor pharmacokinetic properties. In this study, 20 PTM derivatives were prepared by Suzuki-Miyaura cross-coupling reactions catalyzed by Pd (0)/C. Compared to PTM, 6-pyrenyl PTM (6t) showed improved antibacterial activity against MRSA in a mouse peritonitis model. Our results support the strategy to target the essential fatty acid synthases in major pathogens, in order to discover and develop new generations of antibiotics. Topics: Adamantane; Aminobenzoates; Anilides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Docking Simulation; Peritonitis; Staphylococcal Infections | 2018 |
Material surfaces and MRSA.
It appears that our hospitals are facing serious threats from antibiotic-resistant bacteria, especially meticillin-resistant Staphylococcus aureus (MRSA). In this article, some of the new materials related solutions to these threats are discussed Topics: Adamantane; Aminobenzoates; Anilides; Anti-Bacterial Agents; Chlorhexidine; Cross Infection; Equipment and Supplies, Hospital; Equipment Contamination; Infection Control; Intensive Care Units; Methicillin Resistance; Silver; Staphylococcal Infections; Staphylococcus aureus | 2006 |