platencin and Bacterial-Infections

Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-group operations. The second strategy, a protecting group-free route, utilizes a 6-exo-trig radical cyclization and aldol condensation as key steps leading to the formal synthesis of platencin.

Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Aminophenols; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Chemistry, Pharmaceutical; Cyclization; Drug Discovery; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Fatty Acids; Free Radicals; Humans; Lipid Metabolism; Molecular Structure; Polycyclic Compounds; Stereoisomerism