plastochromanol-8 and Leukemia

plastochromanol-8 has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for plastochromanol-8 and Leukemia

Article	Year
Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway. Nutrition and cancer, 2011, Volume: 63, Issue:5 Tocotrienols (Toc3) have been suggested to possess anticancer effects besides antioxidant and antiinflammatory effects. Previous studies have demonstrated that Toc3 induce apoptosis in epithelial carcinoma. However, the effects of Toc3 on malignant hematopoietic cells have not yet been thoroughly investigated. We investigated Toc3-induced apoptosis in human hematological cancer cell lines. α-, δ-, and γ-Toc3 induced concentration-dependent apoptosis, and γ-Toc3 demonstrated more effective induction than the other Toc3 derivatives in HL-60 cells. γ-Toc3 may have induced apoptosis by activation of the caspase cascade, cytochrome c (Cyt.c) release, Bid cleavage, and mitochondorial membrane depolarization in HL-60, NB-4, Raji, and SY-5Y cells. Furthermore, 10-30 μM γ-Toc3 showed cytotoxicity for leukemic cells from various patients regardless of lymphoblastic, myeloblastic, or relapsed leukemia, but the cytotoxic effect was weak in normal mononuclear cells, interestingly. γ-Toc3 may have a role in cancer prevention and potential for treating hematological malignancies. Topics: Adolescent; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Bone Marrow Cells; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Chromans; Cytochromes c; DNA Fragmentation; Female; Hematologic Neoplasms; Humans; Infant; Leukemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Vitamin E	2011

Article

Year

Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway.

Nutrition and cancer, 2011, Volume: 63, Issue:5

Tocotrienols (Toc3) have been suggested to possess anticancer effects besides antioxidant and antiinflammatory effects. Previous studies have demonstrated that Toc3 induce apoptosis in epithelial carcinoma. However, the effects of Toc3 on malignant hematopoietic cells have not yet been thoroughly investigated. We investigated Toc3-induced apoptosis in human hematological cancer cell lines. α-, δ-, and γ-Toc3 induced concentration-dependent apoptosis, and γ-Toc3 demonstrated more effective induction than the other Toc3 derivatives in HL-60 cells. γ-Toc3 may have induced apoptosis by activation of the caspase cascade, cytochrome c (Cyt.c) release, Bid cleavage, and mitochondorial membrane depolarization in HL-60, NB-4, Raji, and SY-5Y cells. Furthermore, 10-30 μM γ-Toc3 showed cytotoxicity for leukemic cells from various patients regardless of lymphoblastic, myeloblastic, or relapsed leukemia, but the cytotoxic effect was weak in normal mononuclear cells, interestingly. γ-Toc3 may have a role in cancer prevention and potential for treating hematological malignancies.

Topics: Adolescent; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Bone Marrow Cells; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Chromans; Cytochromes c; DNA Fragmentation; Female; Hematologic Neoplasms; Humans; Infant; Leukemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Vitamin E

2011