plastochromanol-8 and Leukemia--Myeloid--Acute

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines

Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromans; DNA Fragmentation; Humans; Leukemia, Myeloid, Acute; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Vitamin E