plastochromanol-8 and Hepatoblastoma

plastochromanol-8 has been researched along with Hepatoblastoma* in 1 studies

Other Studies

1 other study(ies) available for plastochromanol-8 and Hepatoblastoma

Article	Year
Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. BMC complementary and alternative medicine, 2015, Mar-13, Volume: 15 To determine the antiproliferative effect of gamma-tocotrienol (GTT) treatment on differential protein expression in HepG2 cells.. HepG2 cells were treated with 70 μM GTT for 48 hours and differentially expressed protein spots were determined by two-dimensional electrophoresis (2DE), identified by MALDI-TOF mass spectrometer (MS) and validated by quantitative real-time polymerase chain reaction (qRT-PCR).. GTT treatment on HepG2 cells showed a total of five differentially expressed proteins when compared to their respective untreated cells where three proteins were down-regulated and two proteins were up-regulated. One of these upregulated proteins was identified as peroxiredoxin-4 (Prx4). Validation by qRT-PCR however showed decreased expression of Prx4 mRNA in HepG2 cells following GTT treatment.. GTT might directly influence the expression dynamics of peroxiredoxin-4 to control proliferation in liver cancer. Topics: Antineoplastic Agents; Antioxidants; Bile Duct Neoplasms; Chromans; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Hep G2 Cells; Hepatoblastoma; Humans; Liver; Liver Neoplasms; Peroxiredoxins; Proteins; Proteomics; Real-Time Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tocotrienols; Up-Regulation; Vitamin E; Vitamins	2015

Article

Year

Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line.

BMC complementary and alternative medicine, 2015, Mar-13, Volume: 15

To determine the antiproliferative effect of gamma-tocotrienol (GTT) treatment on differential protein expression in HepG2 cells.. HepG2 cells were treated with 70 μM GTT for 48 hours and differentially expressed protein spots were determined by two-dimensional electrophoresis (2DE), identified by MALDI-TOF mass spectrometer (MS) and validated by quantitative real-time polymerase chain reaction (qRT-PCR).. GTT treatment on HepG2 cells showed a total of five differentially expressed proteins when compared to their respective untreated cells where three proteins were down-regulated and two proteins were up-regulated. One of these upregulated proteins was identified as peroxiredoxin-4 (Prx4). Validation by qRT-PCR however showed decreased expression of Prx4 mRNA in HepG2 cells following GTT treatment.. GTT might directly influence the expression dynamics of peroxiredoxin-4 to control proliferation in liver cancer.

Topics: Antineoplastic Agents; Antioxidants; Bile Duct Neoplasms; Chromans; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Hep G2 Cells; Hepatoblastoma; Humans; Liver; Liver Neoplasms; Peroxiredoxins; Proteins; Proteomics; Real-Time Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tocotrienols; Up-Regulation; Vitamin E; Vitamins

2015