plastochromanol-8 has been researched along with Acute-Kidney-Injury* in 1 studies
1 other study(ies) available for plastochromanol-8 and Acute-Kidney-Injury
| Article | Year |
|---|---|
γ-Tocotrienol Protects against Mitochondrial Dysfunction, Energy Deficits, Morphological Damage, and Decreases in Renal Functions after Renal Ischemia.
Ischemia-induced mitochondrial dysfunction and ATP depletion in the kidney result in disruption of primary functions and acute injury of the kidney. This study tested whether γ-tocotrienol (GTT), a member of the vitamin E family, protects mitochondrial function, reduces ATP deficits, and improves renal functions and survival after ischemia/reperfusion injury. Vehicle or GTT (200 mg/kg) were administered to mice 12 h before bilateral kidney ischemia, and endpoints were assessed at different timepoints of reperfusion. GTT treatment reduced decreases in state 3 respiration and accelerated recovery of this function after ischemia. GTT prevented decreases in activities of complexes I and III of the respiratory chain, and blocked ischemia-induced decreases in F Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Chromans; Electron Transport; Energy Metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria; Protective Agents; Reperfusion Injury; Vitamin E | 2021 |