pksi-527 and Disease-Models--Animal

pksi-527 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for pksi-527 and Disease-Models--Animal

Article	Year
A finding of highly selective synthetic inhibitor of plasma kallikrein; its action to bradykinin generation, intrinsic coagulation and experimental DIC. Agents and actions. Supplements, 1992, Volume: 38 ( Pt 1) We found a novel and highly selective synthetic inhibitor of plasma kallikrein (PK), called PKSI-527; the Ki value was 0.81 microM. PKSI-527 inhibited the bradykinin (BK) generation induced by kaolin and prolonged partial thromboplastin time (PTT). PKSI-527 prevented the decrease of fibrinogen (Fg) levels due to i.v. injection of ellagic acid in mice and ameliorated the endotoxin (ET)-induced DIC in rats. Topics: Animals; Blood Coagulation; Bradykinin; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Fibrinogen; Humans; In Vitro Techniques; Kallikreins; Kaolin; Kinetics; Mice; Partial Thromboplastin Time; Phenylalanine; Rats; Tranexamic Acid	1992

Article

Year

A finding of highly selective synthetic inhibitor of plasma kallikrein; its action to bradykinin generation, intrinsic coagulation and experimental DIC.

Agents and actions. Supplements, 1992, Volume: 38 ( Pt 1)

We found a novel and highly selective synthetic inhibitor of plasma kallikrein (PK), called PKSI-527; the Ki value was 0.81 microM. PKSI-527 inhibited the bradykinin (BK) generation induced by kaolin and prolonged partial thromboplastin time (PTT). PKSI-527 prevented the decrease of fibrinogen (Fg) levels due to i.v. injection of ellagic acid in mice and ameliorated the endotoxin (ET)-induced DIC in rats.

Topics: Animals; Blood Coagulation; Bradykinin; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Fibrinogen; Humans; In Vitro Techniques; Kallikreins; Kaolin; Kinetics; Mice; Partial Thromboplastin Time; Phenylalanine; Rats; Tranexamic Acid

1992