pk 11195 has been researched along with Thiamine Deficiency in 2 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leong, DK | 1 |
| Le, O | 1 |
| Oliva, L | 1 |
| Butterworth, RF | 2 |
| Desjardins, P | 1 |
| Todd, KG | 1 |
| Hazell, AS | 1 |
2 other studies available for pk 11195 and Thiamine Deficiency
| Article | Year |
|---|---|
Increased densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand [3H]PK11195 in vulnerable regions of the rat brain in thiamine deficiency encephalopathy.
Topics: Animals; Autoradiography; Binding Sites; Brain; Brain Diseases; Isoquinolines; Ligands; Male; Rats; | 1994 |
Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats.
Topics: Animals; Base Sequence; DNA Primers; Glial Fibrillary Acidic Protein; Isoquinolines; Male; Rats; Rat | 1999 |