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pk 11195 and Tauopathies

pk 11195 has been researched along with Tauopathies in 1 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.

Research Excerpts

ExcerptRelevanceReference
"The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum."1.56Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. ( Aigbirhio, FI; Allinson, K; Arnold, R; Bevan-Jones, WR; Coles, JP; Cope, TE; Fryer, TD; Green, O; Hong, YT; Jones, PS; Kaalund, SS; Larner, AJ; O'Brien, JT; Passamonti, L; Patterson, K; Rowe, JB, 2020)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Bevan-Jones, WR1
Cope, TE1
Jones, PS1
Kaalund, SS1
Passamonti, L1
Allinson, K1
Green, O1
Hong, YT1
Fryer, TD1
Arnold, R1
Coles, JP1
Aigbirhio, FI1
Larner, AJ1
Patterson, K1
O'Brien, JT1
Rowe, JB1

Other Studies

1 other study available for pk 11195 and Tauopathies

ArticleYear
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
    Brain : a journal of neurology, 2020, 03-01, Volume: 143, Issue:3

    Topics: Aged; Carbolines; Carbon Radioisotopes; Case-Control Studies; DNA-Binding Proteins; Female; Frontote

2020