pk 11195 has been researched along with Tauopathies in 1 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum." | 1.56 | Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. ( Aigbirhio, FI; Allinson, K; Arnold, R; Bevan-Jones, WR; Coles, JP; Cope, TE; Fryer, TD; Green, O; Hong, YT; Jones, PS; Kaalund, SS; Larner, AJ; O'Brien, JT; Passamonti, L; Patterson, K; Rowe, JB, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bevan-Jones, WR | 1 |
| Cope, TE | 1 |
| Jones, PS | 1 |
| Kaalund, SS | 1 |
| Passamonti, L | 1 |
| Allinson, K | 1 |
| Green, O | 1 |
| Hong, YT | 1 |
| Fryer, TD | 1 |
| Arnold, R | 1 |
| Coles, JP | 1 |
| Aigbirhio, FI | 1 |
| Larner, AJ | 1 |
| Patterson, K | 1 |
| O'Brien, JT | 1 |
| Rowe, JB | 1 |
1 other study available for pk 11195 and Tauopathies
| Article | Year |
|---|---|
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
Topics: Aged; Carbolines; Carbon Radioisotopes; Case-Control Studies; DNA-Binding Proteins; Female; Frontote | 2020 |