pk 11195 has been researched along with Supranuclear Palsy, Progressive in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Malpetti, M | 1 |
| Passamonti, L | 1 |
| Rittman, T | 1 |
| Jones, PS | 1 |
| Vázquez Rodríguez, P | 1 |
| Bevan-Jones, WR | 1 |
| Hong, YT | 1 |
| Fryer, TD | 1 |
| Aigbirhio, FI | 1 |
| O'Brien, JT | 1 |
| Rowe, JB | 1 |
| Femminella, GD | 1 |
| Ninan, S | 1 |
| Atkinson, R | 1 |
| Fan, Z | 1 |
| Brooks, DJ | 2 |
| Edison, P | 1 |
| Gerhard, A | 1 |
| Trender-Gerhard, I | 1 |
| Turkheimer, F | 1 |
| Quinn, NP | 1 |
| Bhatia, KP | 1 |
3 other studies available for pk 11195 and Supranuclear Palsy, Progressive
| Article | Year |
|---|---|
Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.
Topics: Aged; Brain; Carbolines; Carbon Radioisotopes; Female; Humans; Inflammation Mediators; Isoquinolines | 2020 |
Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antineoplastic Agents; Brain Mapping; Cognition; Female; | 2016 |
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
Topics: Aged; Basal Ganglia; Brain Stem; Carbon Radioisotopes; Cell Death; Female; Frontal Lobe; Humans; Ima | 2006 |