pk 11195 has been researched along with Stroke in 8 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195." | 7.78 | Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012) |
| "With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195." | 3.78 | Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012) |
| "Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death." | 2.61 | Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019) |
| "Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56 days, followed by immunohistochemical endpoint analysis." | 1.42 | In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. ( Backes, H; Fink, GR; Graf, R; Hoehn, M; Neumaier, B; Rueger, MA; Schroeter, M; Walberer, M; Walter, HL; Wiedermann, D, 2015) |
| "Stroke was induced by transient middle cerebral artery occlusion in Balb/c mice." | 1.40 | PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06. ( Ahn, GO; Chen, JW; Chernikova, S; Chin, FT; Chua, JY; Cord, KT; Graves, EE; Guzman, R; James, ML; Lartey, FM; Lee, SW; Liu, H; Loo, BW; Palmer, TD; Pisani, LJ; Rosenblum, S; Shen, B; Smith, T; Tirouvanziam, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, K | 1 |
| Tian, DC | 1 |
| Li, ZG | 1 |
| Ducruet, AF | 1 |
| Lawton, MT | 1 |
| Shi, FD | 1 |
| Lartey, FM | 1 |
| Ahn, GO | 1 |
| Shen, B | 1 |
| Cord, KT | 1 |
| Smith, T | 1 |
| Chua, JY | 1 |
| Rosenblum, S | 1 |
| Liu, H | 1 |
| James, ML | 1 |
| Chernikova, S | 1 |
| Lee, SW | 1 |
| Pisani, LJ | 1 |
| Tirouvanziam, R | 1 |
| Chen, JW | 1 |
| Palmer, TD | 1 |
| Chin, FT | 1 |
| Guzman, R | 1 |
| Graves, EE | 1 |
| Loo, BW | 1 |
| Walberer, M | 2 |
| Jantzen, SU | 1 |
| Backes, H | 2 |
| Rueger, MA | 2 |
| Keuters, MH | 1 |
| Neumaier, B | 3 |
| Hoehn, M | 2 |
| Fink, GR | 2 |
| Graf, R | 2 |
| Schroeter, M | 2 |
| Walter, HL | 1 |
| Wiedermann, D | 1 |
| Radlinska, BA | 1 |
| Ghinani, SA | 1 |
| Lyon, P | 1 |
| Jolly, D | 1 |
| Soucy, JP | 1 |
| Minuk, J | 1 |
| Schirrmacher, R | 1 |
| Thiel, A | 1 |
| Gulyas, B | 1 |
| Toth, M | 1 |
| Vas, A | 1 |
| Shchukin, E | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Halldin, C | 1 |
| Gerhard, A | 1 |
| Elitok, E | 1 |
| Glatting, G | 1 |
| Ries, V | 1 |
| Tomczak, R | 1 |
| Ludolph, AC | 1 |
| Reske, SN | 1 |
| Pappata, S | 1 |
| Levasseur, M | 1 |
| Gunn, RN | 1 |
| Myers, R | 1 |
| Crouzel, C | 1 |
| Syrota, A | 1 |
| Jones, T | 1 |
| Kreutzberg, GW | 1 |
| Banati, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740] | Phase 3 | 1,672 participants (Anticipated) | Interventional | 2023-05-19 | Recruiting | ||
| Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-05-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pk 11195 and Stroke
| Article | Year |
|---|---|
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
7 other studies available for pk 11195 and Stroke
| Article | Year |
|---|---|
PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06.
Topics: Acetanilides; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Autoradiography; Fem | 2014 |
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats.
Topics: Amyloid; Animals; Brain; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Immunohistoc | 2014 |
In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Brain Ischemia; Calcium-Bin | 2015 |
Multimodal microglia imaging of fiber tracts in acute subcortical stroke.
Topics: Adult; Aged; Aged, 80 and over; Brain Mapping; Carbon Isotopes; Cerebral Cortex; Diffusion Magnetic | 2009 |
Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
Topics: Aged; Binding Sites; Biomarkers; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; Male; Mi | 2012 |
In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Ischemia; Carbon Radioisotopes; Cerebra | 2000 |
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Carbon Radioisotopes; Female; Humans; Isoquinolines; | 2000 |