pk 11195 has been researched along with Schizophrenia in 8 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is a brain disease involving progressive loss of gray matter of unknown cause." | 1.35 | Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. ( Boellaard, R; Bossong, MG; Cahn, W; Caspers, E; Kahn, RS; Kloet, R; Lammertsma, AA; Luurtsema, G; Schuitemaker, A; van Berckel, BN; Windhorst, AD, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di Biase, MA | 1 |
| Zalesky, A | 1 |
| O'keefe, G | 1 |
| Laskaris, L | 1 |
| Baune, BT | 1 |
| Weickert, CS | 1 |
| Olver, J | 1 |
| McGorry, PD | 1 |
| Amminger, GP | 1 |
| Nelson, B | 1 |
| Scott, AM | 1 |
| Hickie, I | 1 |
| Banati, R | 1 |
| Turkheimer, F | 1 |
| Yaqub, M | 1 |
| Everall, IP | 1 |
| Pantelis, C | 1 |
| Cropley, V | 1 |
| Holmes, SE | 1 |
| Hinz, R | 1 |
| Drake, RJ | 1 |
| Gregory, CJ | 1 |
| Conen, S | 1 |
| Matthews, JC | 1 |
| Anton-Rodriguez, JM | 1 |
| Gerhard, A | 1 |
| Talbot, PS | 1 |
| van Berckel, BN | 1 |
| Bossong, MG | 1 |
| Boellaard, R | 1 |
| Kloet, R | 1 |
| Schuitemaker, A | 1 |
| Caspers, E | 1 |
| Luurtsema, G | 1 |
| Windhorst, AD | 1 |
| Cahn, W | 1 |
| Lammertsma, AA | 1 |
| Kahn, RS | 1 |
| Kurumaji, A | 1 |
| Wakai, T | 1 |
| Toru, M | 1 |
| Wodarz, N | 1 |
| Rothenhöfer, C | 1 |
| Fischer, R | 1 |
| Stöber, G | 1 |
| Kiehl, B | 1 |
| Jungkunz, G | 1 |
| Riederer, P | 1 |
| Klein, HE | 1 |
| Tanne, Z | 3 |
| Weizman, R | 2 |
| Karp, L | 3 |
| Katz, Y | 1 |
| Tyano, S | 3 |
| Gavish, M | 3 |
| Weizman, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Double Blind Placebo Controlled 12 Week Trial of Methotrexate Added to Treatment As Usual in Early Schizophrenia[NCT02074319] | Phase 1 | 92 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia: A Randomised Placebo-controlled Double-blind Trial[NCT02533232] | Phase 1 | 60 participants (Anticipated) | Interventional | 2022-08-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for pk 11195 and Schizophrenia
| Article | Year |
|---|---|
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Female; Humans; Isoquinolines; Male; Microglia; Posi | 2017 |
In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [
Topics: Adult; Antipsychotic Agents; Brain; Female; Gyrus Cinguli; Humans; Isoquinolines; Male; Microglia; P | 2016 |
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Case-Control Studies; Electrons; Female; Humans; | 2008 |
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Case-Control Studies; Electrons; Female; Humans; | 2008 |
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Case-Control Studies; Electrons; Female; Humans; | 2008 |
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Case-Control Studies; Electrons; Female; Humans; | 2008 |
Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics.
Topics: Adult; Aged; Brain; Brain Chemistry; Chronic Disease; Female; Humans; Isoquinolines; Kinetics; Male; | 1997 |
Peripheral-type benzodiazepine receptors in diagnostic subtypes of schizophrenic patients.
Topics: Adult; Diagnosis, Differential; Female; Granulocytes; Humans; Isoquinolines; Male; Middle Aged; Psyc | 1998 |
Lack of effect of 28 days of neuroleptic treatment on platelet benzodiazepine binding sites in schizophrenics.
Topics: Adolescent; Adult; Blood Platelets; Female; Haloperidol; Humans; Isoquinolines; Male; Psychiatric St | 1987 |
Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics.
Topics: Adult; Antipsychotic Agents; Binding Sites; Blood Platelets; Female; Humans; Isoquinolines; Male; Re | 1986 |
Peripheral-type benzodiazepine-binding sites in platelets of schizophrenics with and without tardive dyskinesia.
Topics: Adult; Binding Sites; Blood Platelets; Dyskinesia, Drug-Induced; Female; Humans; Isoquinolines; Male | 1986 |