pk 11195 has been researched along with Rheumatoid Arthritis in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the effects of different peripheral benzodiazapine receptor ligands: PK 11195 [1-(2-chloro-phenyl)-N-methyl-N-(1-methylpropyl)-1-isoquinoline carboxamide], Ro5-4864 [7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one] and the newly described SSR 180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridozine[4,5-b] indole-1-acetamide) were analysed on the progression and severity of rheumatoid arthritis in vivo in the Mrl/lpr mice model, following chronic treatment (at 3 mg/kg, i." | 3.71 | Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. ( Bourrie, B; Bribes, E; Casellas, P; Esclangon, M; Galiegue, S; Vidal, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gent, YY | 2 |
| Ahmadi, N | 2 |
| Voskuyl, AE | 4 |
| Hoetjes, N | 1 |
| van Kuijk, C | 2 |
| Britsemmer, K | 1 |
| Turkstra, F | 1 |
| Boers, M | 2 |
| Hoekstra, OS | 2 |
| van der Laken, CJ | 4 |
| Ter Wee, MM | 1 |
| den Uyl, D | 1 |
| Dowling, C | 1 |
| Lems, WF | 1 |
| Nozaki, S | 1 |
| Ozaki, N | 1 |
| Suzuki, S | 1 |
| Goto, M | 1 |
| Mawatari, A | 1 |
| Nakatani, Y | 1 |
| Hayashinaka, E | 1 |
| Wada, Y | 1 |
| Doi, H | 1 |
| Watanabe, Y | 1 |
| Narayan, N | 1 |
| Owen, DR | 1 |
| Taylor, PC | 1 |
| Elzinga, EH | 2 |
| Kropholler, MA | 2 |
| Molthoff, CF | 1 |
| van der Heijden, JW | 1 |
| Maruyama, K | 2 |
| Boellaard, R | 2 |
| Dijkmans, BA | 2 |
| Lammertsma, AA | 2 |
| Kloet, RW | 1 |
| Bribes, E | 1 |
| Bourrie, B | 1 |
| Esclangon, M | 1 |
| Galiegue, S | 1 |
| Vidal, H | 1 |
| Casellas, P | 1 |
| Giusti, L | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Mascia, G | 1 |
| Bazzichi, L | 1 |
| Lucacchini, A | 1 |
| Waterfield, JD | 1 |
| McGeer, EG | 1 |
| McGeer, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of a Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions[NCT03912428] | Phase 1 | 111 participants (Anticipated) | Interventional | 2019-06-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pk 11195 and Rheumatoid Arthritis
| Article | Year |
|---|---|
Advances in positron emission tomography for the imaging of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Gallium Radioisotopes; | 2017 |
8 other studies available for pk 11195 and Rheumatoid Arthritis
| Article | Year |
|---|---|
Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Contrast Media; Disease Progression; Female; Fin | 2014 |
Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study.
Topics: Arthritis, Rheumatoid; Disease Progression; Female; Humans; Image Interpretation, Computer-Assisted; | 2015 |
Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [
Topics: Animals; Arthritis, Rheumatoid; Carbon Radioisotopes; Disease Models, Animal; Female; Imaging, Three | 2017 |
Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arthritis, Rheumatoid; Arthroscopy; Benzodi | 2008 |
Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis.
Topics: Adult; Aged; Antineoplastic Agents; Arthritis, Rheumatoid; Carbon Radioisotopes; Female; Humans; Ima | 2009 |
Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice.
Topics: Acetamides; Animals; Antibodies, Blocking; Antirheumatic Agents; Arthritis, Rheumatoid; Benzodiazepi | 2002 |
[3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseases.
Topics: Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Binding Sites; Cell Membrane; Female; Humans; Iso | 2004 |
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Female; GABA-A Recepto | 1999 |