pk 11195 has been researched along with Pregnancy in 14 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosing pregnant dams with alcohol (2x 2." | 1.34 | Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. ( Green, ML; Knudsen, TB; Nemeth, KA; Singh, AV; Sulik, KK; Zhang, Y, 2007) |
| "Treatment with indomethacin, which prevents the formation of PGF2alpha, caused the PBR density in the uterus of pseudopregnant rats at day 53 PP to be twice as high as in pseudopregnant control rats." | 1.33 | The effects of prostaglandin F2alpha treatment on peripheral-type benzodiazepine receptors in the ovary and uterus during pseudopregnancy of rats. ( Bar-Ami, S; Bendel, N; Gavish, M; Leschiner, S; Levin, E; Veenman, L, 2006) |
| "Pregnant CD-1 mice dosed with 2CdA with or without PK11195 on gestation Day 8 provided fetuses for teratologic evaluation on Day 14 and Day 17; HPLC measured pyridine nucleotides (NADH/NAD+) at 1." | 1.32 | Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195. ( Charlap, JH; Donahue, RJ; Knudsen, TB, 2003) |
| "Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation." | 1.30 | Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors. ( Dagan, E; Gavish, M; Snyder, SH; Weizman, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drouin-Ouellet, J | 1 |
| Brownell, AL | 1 |
| Saint-Pierre, M | 1 |
| Fasano, C | 1 |
| Emond, V | 1 |
| Trudeau, LE | 1 |
| Lévesque, D | 1 |
| Cicchetti, F | 1 |
| Kannan, S | 2 |
| Saadani-Makki, F | 2 |
| Balakrishnan, B | 1 |
| Chakraborty, P | 2 |
| Janisse, J | 2 |
| Lu, X | 1 |
| Muzik, O | 2 |
| Romero, R | 2 |
| Chugani, DC | 2 |
| Takai, N | 1 |
| Kira, N | 1 |
| Ishii, T | 1 |
| Yoshida, T | 1 |
| Nishida, M | 1 |
| Nishida, Y | 1 |
| Nasu, K | 1 |
| Takano, M | 1 |
| Midori, H | 1 |
| Koga, S | 1 |
| Narahara, H | 1 |
| Charlap, JH | 1 |
| Donahue, RJ | 1 |
| Knudsen, TB | 2 |
| Bar-Ami, S | 1 |
| Bendel, N | 1 |
| Leschiner, S | 1 |
| Levin, E | 1 |
| Veenman, L | 1 |
| Gavish, M | 5 |
| Green, ML | 1 |
| Singh, AV | 1 |
| Zhang, Y | 1 |
| Nemeth, KA | 1 |
| Sulik, KK | 1 |
| Mangner, TJ | 1 |
| Katz, Y | 1 |
| Amiri, Z | 1 |
| Pick, CG | 1 |
| Weizman, R | 2 |
| Yanai, J | 1 |
| Lin, D | 1 |
| Chang, YJ | 1 |
| Strauss, JF | 1 |
| Miller, WL | 1 |
| Schlumpf, M | 1 |
| Parmar, R | 1 |
| Lichtensteiger, W | 1 |
| Kurumaji, A | 1 |
| Toru, M | 1 |
| Dagan, E | 1 |
| Snyder, SH | 1 |
| Barnea, ER | 1 |
| Fares, F | 2 |
14 other studies available for pk 11195 and Pregnancy
| Article | Year |
|---|---|
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
Topics: Amphetamine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Cells, Cultured; | 2011 |
Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Behavior, Animal; Brain; Carbon Radioisotopes; Cer | 2011 |
A translocator protein ligand PK11195 shows antigrowth activity in human choriocarcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 7; Cell Cycle; C | 2012 |
Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195.
Topics: Animals; Dideoxyadenosine; Drug Evaluation, Preclinical; Eye Abnormalities; Female; Fetal Proteins; | 2003 |
The effects of prostaglandin F2alpha treatment on peripheral-type benzodiazepine receptors in the ovary and uterus during pseudopregnancy of rats.
Topics: Animals; Carrier Proteins; Corpus Luteum; Dinoprost; Female; Gonadotropins, Equine; Indomethacin; Is | 2006 |
Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome.
Topics: Analysis of Variance; Animals; Computational Biology; Ethanol; Eye; Female; Fetal Alcohol Spectrum D | 2007 |
Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET.
Topics: Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Endometritis; Endotoxins; Female; Isoquinoli | 2007 |
Effects of chronic prenatal, neonatal and adult exposure to barbiturates on mitochondrial benzodiazepine receptors in mouse testis.
Topics: Animals; Animals, Newborn; Female; Injections, Subcutaneous; Isoquinolines; Male; Mice; Mitochondria | 1994 |
The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; | 1993 |
Prenatal diazepam induced persisting downregulation of peripheral (omega 3) benzodiazepine receptors on rat splenic macrophages.
Topics: Animals; B-Lymphocytes; Binding Sites; Cell Membrane; Diazepam; Down-Regulation; Female; Isoquinolin | 1993 |
Postnatal development of peripheral-type benzodiazepine receptors in rat brain and peripheral tissues.
Topics: Adrenal Glands; Age Factors; Animals; Brain; Brain Chemistry; Female; Heart; Isoquinolines; Kidney; | 1996 |
Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors.
Topics: Animals; Central Nervous System; Female; Flumazenil; GABA Modulators; Isoquinolines; Lactation; Preg | 1997 |
Modulatory action of benzodiazepines on human term placental steroidogenesis in vitro.
Topics: Benzodiazepines; Benzodiazepinones; Binding, Competitive; Estradiol; Female; Humans; In Vitro Techni | 1989 |
Characterization of peripheral benzodiazepine binding sites in human term placenta.
Topics: Benzodiazepines; Binding, Competitive; Female; Humans; Isoquinolines; Kinetics; Placenta; Pregnancy; | 1986 |