pk 11195 has been researched along with Porphyrias in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozaki, H | 1 |
| Zoghbi, SS | 1 |
| Hong, J | 1 |
| Verma, A | 1 |
| Pike, VW | 1 |
| Innis, RB | 1 |
| Fujita, M | 1 |
| Cantoni, L | 1 |
| Rizzardini, M | 1 |
| Skorupska, M | 1 |
| Cagnotto, A | 1 |
| Codegoni, A | 1 |
| Pecora, N | 1 |
| Frigo, L | 1 |
| Ferrarese, C | 1 |
| Mennini, T | 1 |
| Katz, Y | 1 |
| Weizman, A | 1 |
| Gavish, M | 1 |
3 other studies available for pk 11195 and Porphyrias
| Article | Year |
|---|---|
In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography.
Topics: Acetamides; Animals; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Isoquinolines; Ma | 2010 |
Hepatic protoporphyria is associated with a decrease in ligand binding for the mitochondrial benzodiazepine receptors in the liver.
Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphate; Animals; Binding Sites; Cerebral Cortex; Dicar | 1992 |
Ligands specific to peripheral benzodiazepine receptors for treatment of porphyrias.
Topics: Humans; Isoquinolines; Ligands; Mitochondria; Organ Specificity; Porphyrias; Porphyrins; Receptors, | 1989 |