pk 11195 has been researched along with Parkinson Disease in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1-methyl-propyl]-3-isoquinoline carboxamide), [11C]PIB (11C-Pittsburgh compound B), [18F]FDG-PET (18F-2-fluoro-2-deoxyglucose positron emission tomography) scans." | 1.42 | Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia. ( Ahmed, I; Aman, Y; Brooks, DJ; Chetelat, G; Edison, P; Fan, Z; Landeau, B; Ray Chaudhuri, K, 2015) |
| "We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue." | 1.34 | The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007) |
| "Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with akinesia, tremor and rigidity." | 1.33 | In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. ( Banati, RB; Brooks, DJ; Eggert, K; Es, M; Gerhard, A; Hammers, A; Hotton, G; Oertel, W; Pavese, N; Turkheimer, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, Y | 1 |
| Mozley, PD | 1 |
| Verma, A | 1 |
| Schlyer, D | 1 |
| Henchcliffe, C | 1 |
| Gauthier, SA | 1 |
| Chiao, PC | 1 |
| He, B | 1 |
| Nikolopoulou, A | 1 |
| Logan, J | 1 |
| Sullivan, JM | 1 |
| Pryor, KO | 1 |
| Hesterman, J | 1 |
| Kothari, PJ | 1 |
| Vallabhajosula, S | 1 |
| Fan, Z | 2 |
| Aman, Y | 1 |
| Ahmed, I | 1 |
| Chetelat, G | 1 |
| Landeau, B | 1 |
| Ray Chaudhuri, K | 1 |
| Brooks, DJ | 3 |
| Edison, P | 2 |
| Femminella, GD | 1 |
| Ninan, S | 1 |
| Atkinson, R | 1 |
| Bartels, AL | 1 |
| Willemsen, AT | 1 |
| Doorduin, J | 1 |
| de Vries, EF | 1 |
| Dierckx, RA | 1 |
| Leenders, KL | 1 |
| Ouchi, Y | 1 |
| Yagi, S | 1 |
| Yokokura, M | 1 |
| Sakamoto, M | 1 |
| Gerhard, A | 1 |
| Pavese, N | 1 |
| Hotton, G | 1 |
| Turkheimer, F | 1 |
| Es, M | 1 |
| Hammers, A | 1 |
| Eggert, K | 1 |
| Oertel, W | 1 |
| Banati, RB | 2 |
| Takaya, S | 1 |
| Hashikawa, K | 1 |
| Turkheimer, FE | 1 |
| Mottram, N | 1 |
| Deprez, M | 1 |
| Ishizu, K | 1 |
| Kawashima, H | 1 |
| Akiyama, H | 1 |
| Fukuyama, H | 1 |
| Roncaroli, F | 1 |
| Cicchetti, F | 1 |
| Brownell, AL | 1 |
| Williams, K | 1 |
| Chen, YI | 1 |
| Livni, E | 1 |
| Isacson, O | 1 |
| Bonuccelli, U | 1 |
| Nuti, A | 1 |
| Del Dotto, P | 1 |
| Piccini, P | 1 |
| Martini, C | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Muratorio, A | 1 |
1 review available for pk 11195 and Parkinson Disease
| Article | Year |
|---|---|
Neuroinflammation in the living brain of Parkinson's disease.
Topics: Aged; Brain; Cocaine; Cytokines; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Humans; | 2009 |
1 trial available for pk 11195 and Parkinson Disease
| Article | Year |
|---|---|
[11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
Topics: Aged; Antiparkinson Agents; Brain; Brain Mapping; Case-Control Studies; Celecoxib; Cluster Analysis; | 2010 |
7 other studies available for pk 11195 and Parkinson Disease
| Article | Year |
|---|---|
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.
Topics: Adult; Aged; Brain; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; Parkinson Disease; | 2018 |
Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia.
Topics: Alzheimer Disease; Amyloid; Brain; Brain Mapping; Carbon Radioisotopes; Cognitive Dysfunction; Fluor | 2015 |
Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antineoplastic Agents; Brain Mapping; Cognition; Female; | 2016 |
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
Topics: Aged; Benzodiazepines; Brain; Carbon Radioisotopes; Diagnostic Imaging; Female; Humans; Isoquinoline | 2006 |
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu | 2007 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |
Platelet peripheral benzodiazepine receptors are decreased in Parkinson's disease.
Topics: Aged; Analysis of Variance; Binding Sites; Blood Platelets; Female; Humans; Isoquinolines; Kinetics; | 1991 |