pk 11195 has been researched along with Panic Disorder in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we found that the translocator protein (18 kD) ligand XBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development." | 5.14 | Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. ( Baghai, TC; Bertaina-Anglade, V; Chaperon, F; Eser, D; Floesser, A; Gentsch, C; Holsboer, F; Kalkman, HO; Kiese, B; Kucher, K; La Rochelle, CD; Landgraf, R; McAllister, KH; Nothdurfter, C; Rammes, G; Rupprecht, R; Schüle, C; Schumacher, M; Troxler, T; Tuerck, D; Uzunov, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rupprecht, R | 1 |
| Rammes, G | 1 |
| Eser, D | 1 |
| Baghai, TC | 1 |
| Schüle, C | 1 |
| Nothdurfter, C | 1 |
| Troxler, T | 1 |
| Gentsch, C | 1 |
| Kalkman, HO | 1 |
| Chaperon, F | 1 |
| Uzunov, V | 1 |
| McAllister, KH | 1 |
| Bertaina-Anglade, V | 1 |
| La Rochelle, CD | 1 |
| Tuerck, D | 1 |
| Floesser, A | 1 |
| Kiese, B | 1 |
| Schumacher, M | 1 |
| Landgraf, R | 1 |
| Holsboer, F | 1 |
| Kucher, K | 1 |
| Pini, S | 1 |
| Martini, C | 2 |
| Abelli, M | 1 |
| Muti, M | 1 |
| Gesi, C | 1 |
| Montali, M | 1 |
| Chelli, B | 1 |
| Lucacchini, A | 2 |
| Cassano, GB | 2 |
| Marazziti, D | 1 |
| Rotondo, A | 1 |
| Giannaccini, G | 1 |
| Pancioli-Guadagnucci, ML | 1 |
| Diamond, BI | 1 |
| Borison, R | 1 |
1 trial available for pk 11195 and Panic Disorder
| Article | Year |
|---|---|
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.
Topics: Adult; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Line; Drug Tolerance; gamma-A | 2009 |
2 other studies available for pk 11195 and Panic Disorder
| Article | Year |
|---|---|
Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms.
Topics: Adult; Anxiety, Separation; Binding Sites; Binding, Competitive; Blood Platelets; Female; Humans; Is | 2005 |
Changes in peripheral benzodiazepine receptors in patients with panic disorder and obsessive-compulsive disorder.
Topics: Adolescent; Adult; Biomarkers; Blood Platelets; Cell Membrane; Female; Humans; In Vitro Techniques; | 1994 |