Page last updated: 2024-10-21

pk 11195 and Niemann-Pick Disease, Type C

pk 11195 has been researched along with Niemann-Pick Disease, Type C in 1 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Walterfang, M1
Di Biase, MA1
Cropley, VL1
Scott, AM1
O'Keefe, G1
Velakoulis, D1
Pathmaraj, K1
Ackermann, U1
Pantelis, C1

Other Studies

1 other study available for pk 11195 and Niemann-Pick Disease, Type C

ArticleYear
Imaging of neuroinflammation in adult Niemann-Pick type C disease: A cross-sectional study.
    Neurology, 2020, 04-21, Volume: 94, Issue:16

    Topics: Adult; Anisotropy; Brain; Case-Control Studies; Cross-Sectional Studies; Female; Gray Matter; Humans

2020