pk 11195 has been researched along with Niemann-Pick Disease, Type C in 1 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (100.00) | 2.80 |
Authors | Studies |
---|---|
Walterfang, M | 1 |
Di Biase, MA | 1 |
Cropley, VL | 1 |
Scott, AM | 1 |
O'Keefe, G | 1 |
Velakoulis, D | 1 |
Pathmaraj, K | 1 |
Ackermann, U | 1 |
Pantelis, C | 1 |
1 other study available for pk 11195 and Niemann-Pick Disease, Type C
Article | Year |
---|---|
Imaging of neuroinflammation in adult Niemann-Pick type C disease: A cross-sectional study.
Topics: Adult; Anisotropy; Brain; Case-Control Studies; Cross-Sectional Studies; Female; Gray Matter; Humans | 2020 |