pk 11195 has been researched along with Nerve Degeneration in 14 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imamura, K | 1 |
| Onoe, H | 1 |
| Shimazawa, M | 1 |
| Nozaki, S | 1 |
| Wada, Y | 1 |
| Kato, K | 1 |
| Nakajima, H | 1 |
| Mizuma, H | 1 |
| Onoe, K | 1 |
| Taniguchi, T | 1 |
| Sasaoka, M | 1 |
| Hara, H | 1 |
| Tanaka, S | 1 |
| Araie, M | 1 |
| Watanabe, Y | 1 |
| van Bregt, DR | 1 |
| Thomas, TC | 1 |
| Hinzman, JM | 1 |
| Cao, T | 1 |
| Liu, M | 1 |
| Bing, G | 1 |
| Gerhardt, GA | 1 |
| Pauly, JR | 1 |
| Lifshitz, J | 1 |
| Obernier, JA | 1 |
| White, AM | 1 |
| Swartzwelder, HS | 1 |
| Crews, FT | 1 |
| Henkel, K | 1 |
| Karitzky, J | 1 |
| Schmid, M | 1 |
| Mader, I | 1 |
| Glatting, G | 1 |
| Unger, JW | 1 |
| Neumaier, B | 1 |
| Ludolph, AC | 1 |
| Reske, SN | 1 |
| Landwehrmeyer, GB | 1 |
| Gerhard, A | 1 |
| Watts, J | 1 |
| Trender-Gerhard, I | 1 |
| Turkheimer, F | 1 |
| Banati, RB | 1 |
| Bhatia, K | 1 |
| Brooks, DJ | 1 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Bartels, AL | 1 |
| Leenders, KL | 1 |
| Vas, A | 1 |
| Shchukin, Y | 1 |
| Karrenbauer, VD | 1 |
| Cselényi, Z | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Savic, I | 1 |
| Takano, A | 1 |
| Halldin, C | 1 |
| Gulyás, B | 1 |
| Moresco, RM | 1 |
| Lavazza, T | 1 |
| Belloli, S | 1 |
| Lecchi, M | 1 |
| Pezzola, A | 1 |
| Todde, S | 1 |
| Matarrese, M | 1 |
| Carpinelli, A | 1 |
| Turolla, E | 1 |
| Zimarino, V | 1 |
| Popoli, P | 1 |
| Malgaroli, A | 1 |
| Fazio, F | 1 |
| Bendotti, C | 1 |
| Baldessari, S | 1 |
| Pende, M | 1 |
| Tarizzo, G | 1 |
| Miari, A | 1 |
| Presti, ML | 1 |
| Mennini, T | 1 |
| Samanin, R | 1 |
| Kuhlmann, AC | 1 |
| Guilarte, TR | 1 |
| Sitte, HH | 1 |
| Wanschitz, J | 1 |
| Budka, H | 1 |
| Berger, ML | 1 |
| Rao, VL | 1 |
| Bowen, KK | 1 |
| Rao, AM | 1 |
| Dempsey, RJ | 1 |
| Benavides, J | 1 |
| Capdeville, C | 1 |
| Dauphin, F | 1 |
| Dubois, A | 1 |
| Duverger, D | 1 |
| Fage, D | 1 |
| Gotti, B | 1 |
| MacKenzie, ET | 1 |
| Scatton, B | 1 |
1 review available for pk 11195 and Nerve Degeneration
| Article | Year |
|---|---|
Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cytokines; Disease Models | 2007 |
1 trial available for pk 11195 and Nerve Degeneration
| Article | Year |
|---|---|
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb | 2008 |
12 other studies available for pk 11195 and Nerve Degeneration
| Article | Year |
|---|---|
Molecular imaging reveals unique degenerative changes in experimental glaucoma.
Topics: Animals; Carbon Radioisotopes; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Geniculate Bodies; Gl | 2009 |
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier | 2012 |
Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.
Topics: Animals; Central Nervous System; Cognition; Cognition Disorders; Copper; Ethanol; Isoquinolines; Mal | 2002 |
Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration.
Topics: Aged; Basal Ganglia Diseases; Cerebral Cortex; Functional Laterality; Humans; Isoquinolines; Magneti | 2004 |
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration.
Topics: Aged; Basal Ganglia; Cerebral Cortex; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; N | 2004 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation.
Topics: Animals; Carbon Radioisotopes; Corpus Striatum; Isoquinolines; Kinetics; Microglia; Nerve Degenerati | 2008 |
Does GFAP mRNA and mitochondrial benzodiazepine receptor binding detect serotonergic neuronal degeneration in rat?
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Blotting, Northern; Brain; Brain Chemistry; Glial | 1994 |
Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity.
Topics: Animals; Antineoplastic Agents; Astrocytes; Glial Fibrillary Acidic Protein; Hippocampus; Isoquinoli | 2000 |
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antineoplastic Agents; Autoradiography; Binding Sites; B | 2001 |
Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia.
Topics: Animals; Antineoplastic Agents; Binding Sites; Brain Ischemia; Gene Expression Regulation; Gerbillin | 2001 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso | 1990 |