pk 11195 has been researched along with Muscle Contraction in 8 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Midazolam has no effect on the release of stored Ca2+." | 1.29 | Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles. ( Kai, T; Kanaide, H; Kobayashi, S; Nishimura, J; Takahashi, S; Yoshimura, H, 1995) |
| "Tetrazepam is a benzodiazepine derivative clinically used as a muscle relaxant." | 1.29 | Relaxant effect of tetrazepam on rat uterine smooth muscle: role of calcium movement. ( Herrera, MD; Marhuenda, E; Perez-Guerrero, C, 1996) |
| "PK 11195 which has been shown to inhibit the binding of Ro 5-4864 to cardiac muscle did not antagonize this vasodilatory effect of Ro 5-4864 but increased coronary flow by itself." | 1.27 | Benzodiazepine Ro 5-4864 increases coronary flow. ( French, JF; Grupp, IL; Matlib, MA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thibaut, JP | 1 |
| Monteiro, LM | 1 |
| Leite, LC | 1 |
| Menezes, CM | 1 |
| Lima, LM | 1 |
| Noël, F | 1 |
| Yoshimura, H | 1 |
| Kai, T | 1 |
| Nishimura, J | 1 |
| Kobayashi, S | 1 |
| Takahashi, S | 1 |
| Kanaide, H | 1 |
| Smyth, RJ | 1 |
| Uhlman, EJ | 1 |
| Ruggieri, MR | 1 |
| Perez-Guerrero, C | 1 |
| Herrera, MD | 1 |
| Marhuenda, E | 1 |
| Escubedo, E | 2 |
| Pallas, M | 2 |
| Nuñez, C | 1 |
| Camarasa, J | 2 |
| Devillier, P | 1 |
| Candenas, ML | 1 |
| Naline, E | 1 |
| Advenier, C | 1 |
| Adzet, T | 1 |
| Grupp, IL | 1 |
| French, JF | 1 |
| Matlib, MA | 1 |
8 other studies available for pk 11195 and Muscle Contraction
| Article | Year |
|---|---|
The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Calcium; In Vitro Techniques; Isoquinoli | 2009 |
Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles.
Topics: Animals; Anti-Anxiety Agents; Calcium; Drug Interactions; Flumazenil; Fluorometry; GABA Modulators; | 1995 |
Identification and characterization of a high-affinity peripheral-type benzodiazepine receptor in rabbit urinary bladder.
Topics: Animals; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Muscle Contrac | 1994 |
Relaxant effect of tetrazepam on rat uterine smooth muscle: role of calcium movement.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Calcium; Calcium Channels; Dose-Re | 1996 |
Effects of Ro 5-4864 and PK 11195 in rat duodenum and vas deferens.
Topics: Animals; Benzodiazepinones; Calcium; Carbachol; Cholera Toxin; Duodenum; In Vitro Techniques; Isoqui | 1992 |
Influence of benzodiazepines on the response of the guinea-pig isolated trachea to the contractile action of adenosine.
Topics: 2-Chloroadenosine; Adenosine; Animals; Benzodiazepines; Benzodiazepinones; Epithelium; Guinea Pigs; | 1992 |
Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens.
Topics: Adenosine; Animals; Benzodiazepines; Benzodiazepinones; Drug Synergism; Electric Stimulation; Isoqui | 1991 |
Benzodiazepine Ro 5-4864 increases coronary flow.
Topics: Animals; Benzodiazepinones; Clonazepam; Convulsants; Coronary Circulation; Heart Rate; In Vitro Tech | 1987 |