pk 11195 has been researched along with Multiple System Atrophy in 2 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dodel, R | 1 |
| Spottke, A | 1 |
| Gerhard, A | 2 |
| Reuss, A | 1 |
| Reinecker, S | 1 |
| Schimke, N | 1 |
| Trenkwalder, C | 1 |
| Sixel-Döring, F | 1 |
| Herting, B | 1 |
| Kamm, C | 1 |
| Gasser, T | 1 |
| Sawires, M | 1 |
| Geser, F | 1 |
| Köllensperger, M | 1 |
| Seppi, K | 1 |
| Kloss, M | 1 |
| Krause, M | 1 |
| Daniels, C | 1 |
| Deuschl, G | 1 |
| Böttger, S | 1 |
| Naumann, M | 1 |
| Lipp, A | 1 |
| Gruber, D | 1 |
| Kupsch, A | 1 |
| Du, Y | 1 |
| Turkheimer, F | 2 |
| Brooks, DJ | 2 |
| Klockgether, T | 1 |
| Poewe, W | 1 |
| Wenning, G | 1 |
| Schade-Brittinger, C | 1 |
| Oertel, WH | 1 |
| Eggert, K | 1 |
| Banati, RB | 1 |
| Goerres, GB | 1 |
| Cagnin, A | 1 |
| Myers, R | 1 |
| Gunn, RN | 1 |
| Good, CD | 1 |
| Mathias, CJ | 1 |
| Quinn, N | 1 |
| Schwarz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Randomised, Placebo-controlled Parallel Group Study to Investigate the Effect of EGCG Supplementation on Disease Progression of Patients With Multiple System Atrophy (MSA)[NCT02008721] | Phase 3 | 92 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| An Open Label, Single Site, 48 Week, Randomised Controlled Trial Evaluating the Safety and Efficacy of Exenatide Once-weekly in the Treatment of Patients With Multiple System Atrophy[NCT04431713] | Phase 2 | 50 participants (Anticipated) | Interventional | 2020-09-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pk 11195 and Multiple System Atrophy
| Article | Year |
|---|---|
Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
Topics: Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoquinolines; Magnetic Resonan | 2010 |
Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
Topics: Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoquinolines; Magnetic Resonan | 2010 |
Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
Topics: Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoquinolines; Magnetic Resonan | 2010 |
Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
Topics: Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoquinolines; Magnetic Resonan | 2010 |
1 other study available for pk 11195 and Multiple System Atrophy
| Article | Year |
|---|---|
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.
Topics: Aged; Carbon Radioisotopes; Humans; Isoquinolines; Male; Microglia; Middle Aged; Multiple System Atr | 2003 |