pk 11195 has been researched along with Motor Neuron Disease in 1 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turner, MR | 1 |
| Gerhard, A | 1 |
| Al-Chalabi, A | 1 |
| Shaw, CE | 1 |
| Hughes, RA | 1 |
| Banati, RB | 1 |
| Brooks, DJ | 1 |
| Leigh, PN | 1 |
1 other study available for pk 11195 and Motor Neuron Disease
| Article | Year |
|---|---|
Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.
Topics: Adult; Aged; Antineoplastic Agents; Brain; Cluster Analysis; Electromyography; Female; Frontal Lobe; | 2005 |