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pk 11195 and Motor Neuron Disease

pk 11195 has been researched along with Motor Neuron Disease in 1 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Turner, MR1
Gerhard, A1
Al-Chalabi, A1
Shaw, CE1
Hughes, RA1
Banati, RB1
Brooks, DJ1
Leigh, PN1

Other Studies

1 other study available for pk 11195 and Motor Neuron Disease

ArticleYear
Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.
    Journal of neurology, neurosurgery, and psychiatry, 2005, Volume: 76, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Brain; Cluster Analysis; Electromyography; Female; Frontal Lobe;

2005