pk 11195 has been researched along with MS (Multiple Sclerosis) in 21 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue." | 1.34 | The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Nutma, E | 1 |
| Stephenson, JA | 1 |
| Gorter, RP | 1 |
| de Bruin, J | 1 |
| Boucherie, DM | 1 |
| Donat, CK | 1 |
| Breur, M | 1 |
| van der Valk, P | 1 |
| Matthews, PM | 2 |
| Owen, DR | 1 |
| Amor, S | 1 |
| Sucksdorff, M | 2 |
| Matilainen, M | 1 |
| Tuisku, J | 3 |
| Polvinen, E | 1 |
| Vuorimaa, A | 1 |
| Rokka, J | 3 |
| Nylund, M | 1 |
| Rissanen, E | 3 |
| Airas, L | 3 |
| Nuutinen, S | 1 |
| Paavilainen, T | 2 |
| Rinne, J | 1 |
| Kaunzner, UW | 2 |
| Kang, Y | 2 |
| Monohan, E | 1 |
| Kothari, PJ | 1 |
| Nealon, N | 1 |
| Perumal, J | 1 |
| Vartanian, T | 1 |
| Kuceyeski, A | 1 |
| Vallabhajosula, S | 1 |
| Mozley, PD | 1 |
| Riley, CS | 1 |
| Newman, SM | 1 |
| Gauthier, SA | 2 |
| Zhang, S | 1 |
| Morris, E | 1 |
| Yao, Y | 1 |
| Pandya, S | 1 |
| Hurtado Rua, SM | 1 |
| Park, C | 1 |
| Gillen, KM | 1 |
| Nguyen, TD | 1 |
| Wang, Y | 1 |
| Pitt, D | 1 |
| Parkkola, R | 1 |
| Rinne, JO | 1 |
| Giannetti, P | 2 |
| Politis, M | 2 |
| Su, P | 2 |
| Turkheimer, FE | 2 |
| Malik, O | 2 |
| Keihaninejad, S | 2 |
| Wu, K | 2 |
| Waldman, A | 2 |
| Reynolds, R | 2 |
| Nicholas, R | 2 |
| Piccini, P | 2 |
| Turkheimer, F | 2 |
| Calabresi, PA | 1 |
| Bohnen, NI | 1 |
| Harberts, E | 1 |
| Datta, D | 1 |
| Chen, S | 1 |
| Wohler, JE | 1 |
| Oh, U | 1 |
| Jacobson, S | 1 |
| Debruyne, JC | 3 |
| Van Laere, KJ | 3 |
| Versijpt, J | 3 |
| De Vos, F | 3 |
| Eng, JK | 1 |
| Strijckmans, K | 3 |
| Santens, P | 1 |
| Achten, E | 3 |
| Slegers, G | 3 |
| Korf, J | 3 |
| Dierckx, RA | 3 |
| De Reuck, JL | 3 |
| Keppens, J | 2 |
| Yiangou, Y | 1 |
| Facer, P | 1 |
| Durrenberger, P | 1 |
| Chessell, IP | 1 |
| Naylor, A | 1 |
| Bountra, C | 1 |
| Banati, RR | 1 |
| Anand, P | 1 |
| Takaya, S | 1 |
| Hashikawa, K | 1 |
| Mottram, N | 1 |
| Deprez, M | 1 |
| Ishizu, K | 1 |
| Kawashima, H | 1 |
| Akiyama, H | 1 |
| Fukuyama, H | 1 |
| Banati, RB | 2 |
| Roncaroli, F | 1 |
| Vas, A | 1 |
| Shchukin, Y | 1 |
| Karrenbauer, VD | 1 |
| Cselényi, Z | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Savic, I | 1 |
| Takano, A | 1 |
| Halldin, C | 1 |
| Gulyás, B | 1 |
| Vowinckel, E | 1 |
| Reutens, D | 1 |
| Becher, B | 1 |
| Verge, G | 1 |
| Evans, A | 1 |
| Owens, T | 1 |
| Antel, JP | 1 |
| Agnello, D | 1 |
| Carvelli, L | 1 |
| Muzio, V | 1 |
| Villa, P | 1 |
| Bottazzi, B | 1 |
| Polentarutti, N | 1 |
| Mennini, T | 1 |
| Mantovani, A | 1 |
| Ghezzi, P | 1 |
| Newcombe, J | 1 |
| Gunn, RN | 1 |
| Cagnin, A | 1 |
| Heppner, F | 1 |
| Price, G | 1 |
| Wegner, F | 1 |
| Giovannoni, G | 1 |
| Miller, DH | 1 |
| Perkin, GD | 1 |
| Smith, T | 1 |
| Hewson, AK | 1 |
| Bydder, G | 1 |
| Kreutzberg, GW | 1 |
| Jones, T | 1 |
| Cuzner, ML | 1 |
| Myers, R | 1 |
| Ferrero, P | 1 |
| Rocca, P | 1 |
| Benna, P | 1 |
| De Leo, C | 1 |
| Montalenti, E | 1 |
| Ravizza, L | 1 |
| Bergamasco, B | 1 |
| Benavides, J | 1 |
| Cornu, P | 1 |
| Dennis, T | 1 |
| Dubois, A | 1 |
| Hauw, JJ | 1 |
| MacKenzie, ET | 1 |
| Sazdovitch, V | 1 |
| Scatton, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage[NCT04088630] | Early Phase 1 | 28 participants (Actual) | Interventional | 2020-08-07 | Active, not recruiting | ||
| Safety and Efficacy of Subcutaneous Cladribine for Nonrelapsing, Secondary Progressive Multiple Sclerosis (CLASP-MS): a Randomized, Placebo-controlled, Double-blind, Phase 2 Study.[NCT05961644] | Phase 2/Phase 3 | 188 participants (Anticipated) | Interventional | 2022-10-03 | Recruiting | ||
| Evaluation of the Degree of Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Positron Emission Tomography With Amyloid Markers (PET-CT 18F-Florbetaben) and Comparison With MRI Findings[NCT05783934] | 20 participants (Anticipated) | Interventional | 2021-07-27 | Recruiting | |||
| Does Targeting of Sphingosine-1 Phosphate Receptors Reduce Microglial Activation in Multiple Sclerosis? A [11C]PK11195 Brain PET Study[NCT02139696] | 10 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| Brain Inflammation In Major Depressive Disorder[NCT01851356] | 61 participants (Actual) | Observational | 2013-05-08 | Completed | |||
| Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392] | Early Phase 1 | 16 participants (Actual) | Interventional | 2014-05-14 | Completed | ||
| Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy[NCT01793532] | 38 participants (Actual) | Observational | 2013-01-31 | Completed | |||
| Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis[NCT00563537] | Phase 1 | 30 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| PET Imaging of Peripheral Benzodiazepine Receptors Using [11C](R)-PK 11195 and [11C]PBR28[NCT00696371] | 15 participants (Actual) | Observational | 2008-06-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for pk 11195 and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.
Topics: Adult; Aged; Antineoplastic Agents; Atrophy; Brain; Carbon Radioisotopes; Female; Humans; Isoquinoli | 2005 |
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb | 2008 |
19 other studies available for pk 11195 and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis.
Topics: Acetamides; Aged; Aged, 80 and over; Astrocytes; Autopsy; Female; Genotype; Homeostasis; Humans; Iso | 2019 |
Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis.
Topics: Adult; Brain; Cohort Studies; Disability Evaluation; Disease Progression; Female; Humans; Isoquinoli | 2020 |
Evaluation of the Effect of Fingolimod Treatment on Microglial Activation Using Serial PET Imaging in Multiple Sclerosis.
Topics: Adolescent; Adult; Aged; Carbon Radioisotopes; Female; Fingolimod Hydrochloride; Humans; Isoquinolin | 2017 |
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation.
Topics: Adult; Antineoplastic Agents; Female; Humans; Immunologic Factors; Isoquinolines; Longitudinal Studi | 2017 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
In Vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using PET Imaging and the Radioligand ¹¹C-PK11195.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Case-Control Studies; Disease Progression; Female; Humans; | 2014 |
Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome.
Topics: Adult; Antineoplastic Agents; Brain; Disability Evaluation; Female; Humans; Isoquinolines; Longitudi | 2015 |
Increased PK11195 PET binding in the cortex of patients with MS correlates with disability.
Topics: Adult; Cerebral Cortex; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; Multiple Sclero | 2012 |
Can PET imaging tell us what's the matter with the gray matter in multiple sclerosis?
Topics: Cerebral Cortex; Female; Humans; Isoquinolines; Male; Microglia; Multiple Sclerosis; Radionuclide Im | 2012 |
Translocator protein 18 kDa (TSPO) expression in multiple sclerosis patients.
Topics: Acetamides; Adult; Biomarkers; Brain; Cell Separation; Female; Humans; Isoquinolines; Leukocytes, Mo | 2013 |
Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients.
Topics: Adult; Benzodiazepines; Brain; Female; Humans; Isoquinolines; Ligands; Magnetic Resonance Imaging; M | 2002 |
PET visualization of microglia in multiple sclerosis patients using [11C]PK11195.
Topics: Adult; Age Factors; Antineoplastic Agents; Brain Mapping; Cohort Studies; Female; Humans; Isoquinoli | 2003 |
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotti | 2006 |
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu | 2007 |
PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis.
Topics: Animals; Biomarkers; Brain; Encephalomyelitis, Autoimmune, Experimental; Humans; Isoquinolines; Magn | 1997 |
Increased peripheral benzodiazepine binding sites and pentraxin 3 expression in the spinal cord during EAE: relation to inflammatory cytokines and modulation by dexamethasone and rolipram.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; C-Reactive Protein; Dexamethasone; E | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Topics: Adult; Animals; Antineoplastic Agents; Benzodiazepines; Binding Sites; Brain; Carbon Radioisotopes; | 2000 |
An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis.
Topics: Adult; Cell Membrane; Humans; Isoquinolines; Kinetics; Monocytes; Multiple Sclerosis; Receptors, GAB | 1992 |
Imaging of human brain lesions with an omega 3 site radioligand.
Topics: Adult; Aged; Autoradiography; Brain; Brain Ischemia; Brain Neoplasms; Glioblastoma; Humans; Isoquino | 1988 |