pk 11195 has been researched along with Inflammation in 43 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "diazepam treatment reduced the magnitude of the increase in vascular permeability caused by carrageenin; 5." | 5.31 | Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J, 2001) |
| " Tissue of 8 tumors was examined with immunohistochemistry markers for inflammation (Iba1), neoplastic cells (S-100 protein), vessels (CD31), the PK11195 target translocator protein (TSPO), fibrinogen for vascular permeability, and proliferation (Ki-67)." | 3.91 | Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma. ( Agushi, E; Atkinson, R; Coope, DJ; Evans, DG; Freeman, SR; Hammerbeck-Ward, C; Hinz, R; Hulme, S; Jackson, A; King, AT; Lewis, D; Li, KL; Lloyd, SKL; Mayers, H; Mosses, D; Pathmanaban, O; Roncaroli, F; Rutherford, SA; Stapleton, E; Wadeson, A; Williams, R; Zhu, X, 2019) |
| "Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear." | 2.52 | PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015) |
| "The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum." | 1.56 | Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. ( Aigbirhio, FI; Allinson, K; Arnold, R; Bevan-Jones, WR; Coles, JP; Cope, TE; Fryer, TD; Green, O; Hong, YT; Jones, PS; Kaalund, SS; Larner, AJ; O'Brien, JT; Passamonti, L; Patterson, K; Rowe, JB, 2020) |
| "Major depressive disorder is associated with raised peripheral inflammatory markers." | 1.48 | Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study. ( Anton-Rodriguez, JM; Conen, S; Gerhard, A; Gregory, CJ; Hinz, R; Holmes, SE; Matthews, JC; Talbot, PS, 2018) |
| "Stroke was induced by transient middle cerebral artery occlusion in Balb/c mice." | 1.40 | PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06. ( Ahn, GO; Chen, JW; Chernikova, S; Chin, FT; Chua, JY; Cord, KT; Graves, EE; Guzman, R; James, ML; Lartey, FM; Lee, SW; Liu, H; Loo, BW; Palmer, TD; Pisani, LJ; Rosenblum, S; Shen, B; Smith, T; Tirouvanziam, R, 2014) |
| "Neuroinflammation is present in widespread brain areas in CFS/ME patients and was associated with the severity of neuropsychologic symptoms." | 1.40 | Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study. ( Fukuda, S; Inaba, M; Ishii, A; Kataoka, Y; Kawabe, J; Kuratsune, H; Mizuno, K; Nakatomi, Y; Onoe, K; Shiomi, S; Takahashi, K; Tanaka, M; Tazawa, S; Wada, Y; Watanabe, Y; Yamaguti, K, 2014) |
| "(18)F-DPA-714 appears to be an attractive alternative to (11)C-PK11195 because of its increased bioavailability in brain tissue and its reduced nonspecific binding." | 1.35 | Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. ( Boutin, H; Chauveau, F; Damont, A; Dollé, F; Hinnen, F; James, M; Kassiou, M; Kuhnast, B; Tavitian, B; Van Camp, N, 2009) |
| "diazepam treatment reduced the magnitude of the increase in vascular permeability caused by carrageenin; 5." | 1.31 | Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J, 2001) |
| "By contrast, patients with Alzheimer's disease showed significantly increased regional [11C](R)-PK11195 binding in the entorhinal, temporoparietal, and cingulate cortex." | 1.31 | In-vivo measurement of activated microglia in dementia. ( Banati, RB; Brooks, DJ; Cagnin, A; Gunn, RN; Jones, T; Kennedy, AM; Myers, R; Turkheimer, FE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 15 (34.88) | 29.6817 |
| 2010's | 20 (46.51) | 24.3611 |
| 2020's | 5 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Yanamoto, K | 1 |
| Kumata, K | 1 |
| Yamasaki, T | 1 |
| Odawara, C | 1 |
| Kawamura, K | 1 |
| Yui, J | 1 |
| Hatori, A | 1 |
| Suzuki, K | 1 |
| Zhang, MR | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Parbo, P | 1 |
| Madsen, LS | 1 |
| Ismail, R | 1 |
| Zetterberg, H | 1 |
| Blennow, K | 1 |
| Eskildsen, SF | 1 |
| Vorup-Jensen, T | 1 |
| Brooks, DJ | 4 |
| Bevan-Jones, WR | 1 |
| Cope, TE | 1 |
| Jones, PS | 1 |
| Kaalund, SS | 1 |
| Passamonti, L | 1 |
| Allinson, K | 1 |
| Green, O | 1 |
| Hong, YT | 1 |
| Fryer, TD | 1 |
| Arnold, R | 1 |
| Coles, JP | 1 |
| Aigbirhio, FI | 1 |
| Larner, AJ | 1 |
| Patterson, K | 1 |
| O'Brien, JT | 1 |
| Rowe, JB | 1 |
| Walterfang, M | 1 |
| Di Biase, MA | 1 |
| Cropley, VL | 1 |
| Scott, AM | 1 |
| O'Keefe, G | 1 |
| Velakoulis, D | 1 |
| Pathmaraj, K | 1 |
| Ackermann, U | 1 |
| Pantelis, C | 1 |
| Chugani, HT | 2 |
| Kumar, A | 2 |
| Stær, K | 1 |
| Iranzo, A | 1 |
| Stokholm, MG | 1 |
| Østergaard, K | 1 |
| Serradell, M | 1 |
| Otto, M | 1 |
| Svendsen, KB | 1 |
| Garrido, A | 1 |
| Vilas, D | 1 |
| Santamaria, J | 1 |
| Møller, A | 1 |
| Gaig, C | 1 |
| Borghammer, P | 1 |
| Tolosa, E | 1 |
| Pavese, N | 1 |
| Holmes, SE | 1 |
| Hinz, R | 3 |
| Conen, S | 1 |
| Gregory, CJ | 1 |
| Matthews, JC | 1 |
| Anton-Rodriguez, JM | 1 |
| Gerhard, A | 3 |
| Talbot, PS | 1 |
| Abid, KA | 1 |
| Sobowale, OA | 1 |
| Parkes, LM | 1 |
| Naish, J | 1 |
| Parker, GJM | 1 |
| du Plessis, D | 1 |
| Brough, D | 1 |
| Barrington, J | 1 |
| Allan, SM | 1 |
| Parry-Jones, AR | 1 |
| Jung, YH | 1 |
| Kim, H | 1 |
| Jeon, SY | 1 |
| Kwon, JM | 1 |
| Lee, WJ | 1 |
| Kim, YC | 1 |
| Jang, JH | 1 |
| Choi, SH | 1 |
| Lee, JY | 1 |
| Kang, DH | 1 |
| Lewis, D | 1 |
| Roncaroli, F | 1 |
| Agushi, E | 1 |
| Mosses, D | 1 |
| Williams, R | 1 |
| Li, KL | 1 |
| Zhu, X | 1 |
| Atkinson, R | 1 |
| Wadeson, A | 1 |
| Hulme, S | 1 |
| Mayers, H | 1 |
| Stapleton, E | 1 |
| Lloyd, SKL | 1 |
| Freeman, SR | 1 |
| Rutherford, SA | 1 |
| Hammerbeck-Ward, C | 1 |
| Evans, DG | 1 |
| Pathmanaban, O | 1 |
| Jackson, A | 1 |
| King, AT | 1 |
| Coope, DJ | 1 |
| Kaunzner, UW | 1 |
| Kang, Y | 1 |
| Zhang, S | 1 |
| Morris, E | 1 |
| Yao, Y | 1 |
| Pandya, S | 1 |
| Hurtado Rua, SM | 1 |
| Park, C | 1 |
| Gillen, KM | 1 |
| Nguyen, TD | 1 |
| Wang, Y | 1 |
| Pitt, D | 1 |
| Gauthier, SA | 1 |
| Azrad, M | 1 |
| Zeineh, N | 1 |
| Weizman, A | 1 |
| Veenman, L | 1 |
| Gavish, M | 1 |
| Bader, S | 1 |
| Wolf, L | 1 |
| Milenkovic, VM | 1 |
| Gruber, M | 1 |
| Nothdurfter, C | 1 |
| Rupprecht, R | 1 |
| Wetzel, CH | 1 |
| Lartey, FM | 1 |
| Ahn, GO | 1 |
| Shen, B | 1 |
| Cord, KT | 1 |
| Smith, T | 1 |
| Chua, JY | 1 |
| Rosenblum, S | 1 |
| Liu, H | 1 |
| James, ML | 2 |
| Chernikova, S | 1 |
| Lee, SW | 1 |
| Pisani, LJ | 1 |
| Tirouvanziam, R | 1 |
| Chen, JW | 1 |
| Palmer, TD | 1 |
| Chin, FT | 1 |
| Guzman, R | 1 |
| Graves, EE | 1 |
| Loo, BW | 1 |
| Hommet, C | 1 |
| Mondon, K | 1 |
| Camus, V | 1 |
| Ribeiro, MJ | 1 |
| Beaufils, E | 1 |
| Arlicot, N | 2 |
| Corcia, P | 1 |
| Paccalin, M | 1 |
| Minier, F | 1 |
| Gosselin, T | 1 |
| Page, G | 1 |
| Guilloteau, D | 2 |
| Chalon, S | 2 |
| Nakatomi, Y | 1 |
| Mizuno, K | 1 |
| Ishii, A | 1 |
| Wada, Y | 2 |
| Tanaka, M | 1 |
| Tazawa, S | 1 |
| Onoe, K | 1 |
| Fukuda, S | 1 |
| Kawabe, J | 1 |
| Takahashi, K | 1 |
| Kataoka, Y | 1 |
| Shiomi, S | 1 |
| Yamaguti, K | 1 |
| Inaba, M | 1 |
| Kuratsune, H | 1 |
| Watanabe, Y | 2 |
| Williams, MT | 1 |
| Su, YY | 1 |
| Yang, GF | 1 |
| Lu, GM | 1 |
| Wu, S | 1 |
| Zhang, LJ | 1 |
| Haarman, BC | 1 |
| Burger, H | 1 |
| Doorduin, J | 1 |
| Renken, RJ | 1 |
| Sibeijn-Kuiper, AJ | 1 |
| Marsman, JB | 1 |
| de Vries, EF | 1 |
| de Groot, JC | 1 |
| Drexhage, HA | 1 |
| Mendes, R | 1 |
| Nolen, WA | 1 |
| Riemersma-Van der Lek, RF | 1 |
| Middleton, RJ | 1 |
| Liu, GJ | 1 |
| Banati, RB | 5 |
| Moraga, A | 1 |
| Gómez-Vallejo, V | 1 |
| Cuartero, MI | 1 |
| Szczupak, B | 1 |
| San Sebastián, E | 1 |
| Markuerkiaga, I | 1 |
| Pradillo, JM | 1 |
| Higuchi, M | 1 |
| Llop, J | 2 |
| Moro, MÁ | 1 |
| Martín, A | 2 |
| Lizasoain, I | 1 |
| Nozaki, S | 1 |
| Ozaki, N | 1 |
| Suzuki, S | 1 |
| Goto, M | 1 |
| Mawatari, A | 1 |
| Nakatani, Y | 1 |
| Hayashinaka, E | 1 |
| Doi, H | 1 |
| Katsifis, A | 1 |
| Garreau, L | 1 |
| Mattner, F | 1 |
| Vergote, J | 1 |
| Duval, S | 1 |
| Kousignian, I | 1 |
| Bodard, S | 1 |
| Laitinen, I | 1 |
| Marjamäki, P | 1 |
| Någren, K | 1 |
| Laine, VJ | 1 |
| Wilson, I | 1 |
| Leppänen, P | 1 |
| Ylä-Herttuala, S | 1 |
| Roivainen, A | 1 |
| Knuuti, J | 1 |
| Venneti, S | 1 |
| Wang, G | 1 |
| Nguyen, J | 1 |
| Wiley, CA | 1 |
| Chauveau, F | 2 |
| Van Camp, N | 1 |
| Dollé, F | 2 |
| Kuhnast, B | 1 |
| Hinnen, F | 1 |
| Damont, A | 1 |
| Boutin, H | 2 |
| James, M | 1 |
| Kassiou, M | 3 |
| Tavitian, B | 2 |
| Kreisl, WC | 1 |
| Fujita, M | 1 |
| Fujimura, Y | 1 |
| Kimura, N | 1 |
| Jenko, KJ | 1 |
| Kannan, P | 1 |
| Hong, J | 1 |
| Morse, CL | 1 |
| Zoghbi, SS | 1 |
| Gladding, RL | 1 |
| Jacobson, S | 1 |
| Oh, U | 1 |
| Pike, VW | 1 |
| Innis, RB | 1 |
| Gaemperli, O | 1 |
| Boyle, JJ | 1 |
| Rimoldi, OE | 1 |
| Mason, JC | 1 |
| Camici, PG | 1 |
| Ramlackhansingh, AF | 1 |
| Greenwood, RJ | 1 |
| Bose, SK | 1 |
| Turkheimer, FE | 2 |
| Kinnunen, KM | 1 |
| Gentleman, S | 1 |
| Heckemann, RA | 1 |
| Gunanayagam, K | 1 |
| Gelosa, G | 1 |
| Sharp, DJ | 1 |
| Cagnin, A | 4 |
| Thominiaux, C | 1 |
| Grégoire, MC | 1 |
| Trebossen, R | 1 |
| Hantraye, P | 1 |
| Deane, NG | 1 |
| Manning, HC | 1 |
| Foutch, AC | 1 |
| Washington, MK | 1 |
| Aronow, BJ | 1 |
| Aronow, BA | 1 |
| Bornhop, DJ | 1 |
| Coffey, RJ | 1 |
| Rojas, S | 1 |
| Arranz, MJ | 1 |
| Pareto, D | 1 |
| Purroy, J | 1 |
| Verdaguer, E | 1 |
| Gómez, V | 1 |
| Gispert, JD | 1 |
| Millán, O | 1 |
| Chamorro, A | 1 |
| Planas, AM | 1 |
| Meikle, SR | 1 |
| Anseloni, VC | 1 |
| Gold, MS | 1 |
| Myers, R | 2 |
| Cremer, J | 1 |
| Dumont, F | 1 |
| De Vos, F | 1 |
| Versijpt, J | 1 |
| Jansen, HM | 1 |
| Korf, J | 1 |
| Dierckx, RA | 1 |
| Slegers, G | 1 |
| Torres, SR | 2 |
| Nardi, GM | 2 |
| Ferrara, P | 2 |
| Ribeiro-do-Valle, RM | 2 |
| Farges, RC | 2 |
| Fröde, TS | 1 |
| Vita, N | 1 |
| Reeb, R | 1 |
| Lazzarini, R | 1 |
| Malucelli, BE | 1 |
| Palermo-Neto, J | 1 |
| Kennedy, AM | 1 |
| Gunn, RN | 1 |
| Jones, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207] | 160 participants (Anticipated) | Observational | 2019-10-01 | Recruiting | |||
| Naturalistic Monitoring of Microglial Activation in Inflammatory Bowel Disease[NCT03487926] | 135 participants (Anticipated) | Observational | 2022-09-14 | Active, not recruiting | |||
| Safety and Efficacy of Subcutaneous Cladribine for Nonrelapsing, Secondary Progressive Multiple Sclerosis (CLASP-MS): a Randomized, Placebo-controlled, Double-blind, Phase 2 Study.[NCT05961644] | Phase 2/Phase 3 | 188 participants (Anticipated) | Interventional | 2022-10-03 | Recruiting | ||
| Evaluation of the Degree of Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Positron Emission Tomography With Amyloid Markers (PET-CT 18F-Florbetaben) and Comparison With MRI Findings[NCT05783934] | 20 participants (Anticipated) | Interventional | 2021-07-27 | Recruiting | |||
| Whole Brain Connectivity Changes Induced by Traumatic Coma: Combined Structural, Functional and Neuroinflammatory Approaches[NCT03482115] | 59 participants (Actual) | Interventional | 2018-03-07 | Completed | |||
| Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy[NCT01793532] | 38 participants (Actual) | Observational | 2013-01-31 | Completed | |||
| Brain Inflammation In Major Depressive Disorder[NCT01851356] | 61 participants (Actual) | Observational | 2013-05-08 | Completed | |||
| Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392] | Early Phase 1 | 16 participants (Actual) | Interventional | 2014-05-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for pk 11195 and Inflammation
| Article | Year |
|---|---|
Neuroinflammation and β amyloid deposition in Alzheimer's disease: in vivo quantification with molecular imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles | 2014 |
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea | 2015 |
Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Energy Metabolism; Inflamm | 2015 |
In vivo imaging of neuroinflammation.
Topics: Animals; Binding Sites; Brain; Brain Diseases; Carbon Radioisotopes; Humans; Inflammation; Isoquinol | 2002 |
Positron emission tomography imaging of neuroinflammation.
Topics: Animals; Brain; Brain Diseases; Carbon Radioisotopes; Humans; Inflammation; Isoquinolines; Microglia | 2007 |
The concept of in vivo imaging of neuroinflammation with [11C](R)-PK11195 PET.
Topics: Antineoplastic Agents; Benzodiazepines; Binding Sites; Central Nervous System; Humans; Inflammation; | 2002 |
37 other studies available for pk 11195 and Inflammation
| Article | Year |
|---|---|
[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.
Topics: Animals; Brain; Chemistry, Pharmaceutical; Drug Design; Fluorine Radioisotopes; Humans; Inflammation | 2009 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Carbon Radioisotopes; Cognitive Dysfunction; Female; Humans; In | 2020 |
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
Topics: Aged; Carbolines; Carbon Radioisotopes; Case-Control Studies; DNA-Binding Proteins; Female; Frontote | 2020 |
Imaging of neuroinflammation in adult Niemann-Pick type C disease: A cross-sectional study.
Topics: Adult; Anisotropy; Brain; Case-Control Studies; Cross-Sectional Studies; Female; Gray Matter; Humans | 2020 |
Neuroinflammation in Children With Infantile Spasms: A Prospective Study Before and After Treatment With Acthar Gel (Repository Corticotropin Injection).
Topics: Adrenocorticotropic Hormone; Brain; Carbon Radioisotopes; Child, Preschool; Electroencephalography; | 2020 |
Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder.
Topics: Acetylcholinesterase; Aged; Carbon Radioisotopes; Cerebral Cortex; Cholinesterase Inhibitors; Cognit | 2020 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.
Topics: Adult; Aged, 80 and over; Brain; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Female; Humans; H | 2018 |
Brain Metabolites and Peripheral Biomarkers Associated with Neuroinflammation in Complex Regional Pain Syndrome Using [11C]-(R)-PK11195 Positron Emission Tomography and Magnetic Resonance Spectroscopy: A Pilot Study.
Topics: Adult; Basophils; Biomarkers; Blood Glucose; Brain; Carbon Dioxide; Carbon Radioisotopes; Complex Re | 2019 |
Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma.
Topics: Adult; Aged; Aged, 80 and over; Calcium-Binding Proteins; Capillary Permeability; Carbon Radioisotop | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C | 2019 |
The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS.
Topics: Animals; Blotting, Western; Carbamates; Cell Line; Inflammation; Isoquinolines; Lipopolysaccharides; | 2019 |
Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells.
Topics: Animals; Benzodiazepinones; Cell Line; Inflammation; Isoquinolines; Ligands; Lipopolysaccharides; Mi | 2019 |
PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06.
Topics: Acetanilides; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Autoradiography; Fem | 2014 |
Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.
Topics: Adult; Carbon Radioisotopes; Cytokines; Fatigue Syndrome, Chronic; Female; Humans; Inflammation; Iso | 2014 |
Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195.
Topics: Adolescent; Adult; Aging; Autoimmune Diseases; Basal Ganglia; Carbon Radioisotopes; Child; Humans; I | 2015 |
Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study.
Topics: Adult; Aged; Bipolar Disorder; Carbon Radioisotopes; Female; Hippocampus; Humans; Inflammation; Isoq | 2016 |
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.
Topics: Animals; Brain Ischemia; Cell Proliferation; Cerebral Arterial Diseases; Cerebral Infarction; Dideox | 2016 |
Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [
Topics: Animals; Arthritis, Rheumatoid; Carbon Radioisotopes; Disease Models, Animal; Female; Imaging, Three | 2017 |
Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Im | 2008 |
Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.
Topics: Animals; Aorta; Atherosclerosis; Autoradiography; Biomarkers; Carbon Radioisotopes; Feasibility Stud | 2009 |
The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders.
Topics: Acetamides; Aged; Aged, 80 and over; Autoradiography; Brain; Female; Humans; Inflammation; Isoquinol | 2008 |
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation.
Topics: Acetamides; Acute Disease; Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Fluorine Radi | 2009 |
Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.
Topics: Acetamides; Adult; Animals; Biomarkers; Carbon Radioisotopes; Female; Haplorhini; Humans; Inflammati | 2010 |
Molecular imaging of vascular inflammation.
Topics: Aged, 80 and over; Blood Vessels; Female; Giant Cell Arteritis; Humans; Inflammation; Isoquinolines; | 2010 |
Inflammation after trauma: microglial activation and traumatic brain injury.
Topics: Adult; Amnesia; Brain Injuries; Cluster Analysis; Cognition Disorders; Diffusion Tensor Imaging; Edu | 2011 |
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood-Brain Barrier; | 2007 |
Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.
Topics: Animals; Biomarkers, Tumor; Carbocyanines; Colonic Neoplasms; Diagnosis, Differential; Fluorescent D | 2007 |
Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats.
Topics: Animals; Autoradiography; Blotting, Western; Brain; Cerebral Hemorrhage; Cerebral Infarction; Image | 2007 |
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA | 2008 |
Imaging inflammation in the CNS.
Topics: Animals; Autoradiography; Central Nervous System; Facial Nerve; Inflammation; Isoquinolines; Ligands | 1994 |
In vivo evaluation in mice and metabolism in blood of human volunteers of [123I]iodo-PK11195: a possible single-photon emission tomography tracer for visualization of inflammation.
Topics: Adult; Animals; Antineoplastic Agents; Female; Humans; Inflammation; Iodine Radioisotopes; Isoquinol | 1999 |
Potential role of peripheral benzodiazepine receptors in inflammatory responses.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Benzodiazepinones; Carrageenan; Dose-Response Rela | 1999 |
Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzodiazepinones; Disease Models, Animal; | 2000 |
Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone.
Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepinones; C | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |