pk 11195 has been researched along with Idiopathic Parkinson Disease in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1-methyl-propyl]-3-isoquinoline carboxamide), [11C]PIB (11C-Pittsburgh compound B), [18F]FDG-PET (18F-2-fluoro-2-deoxyglucose positron emission tomography) scans." | 1.42 | Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia. ( Ahmed, I; Aman, Y; Brooks, DJ; Chetelat, G; Edison, P; Fan, Z; Landeau, B; Ray Chaudhuri, K, 2015) |
| "We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue." | 1.34 | The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007) |
| "Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with akinesia, tremor and rigidity." | 1.33 | In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. ( Banati, RB; Brooks, DJ; Eggert, K; Es, M; Gerhard, A; Hammers, A; Hotton, G; Oertel, W; Pavese, N; Turkheimer, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, Y | 1 |
| Mozley, PD | 1 |
| Verma, A | 1 |
| Schlyer, D | 1 |
| Henchcliffe, C | 1 |
| Gauthier, SA | 1 |
| Chiao, PC | 1 |
| He, B | 1 |
| Nikolopoulou, A | 1 |
| Logan, J | 1 |
| Sullivan, JM | 1 |
| Pryor, KO | 1 |
| Hesterman, J | 1 |
| Kothari, PJ | 1 |
| Vallabhajosula, S | 1 |
| Fan, Z | 2 |
| Aman, Y | 1 |
| Ahmed, I | 1 |
| Chetelat, G | 1 |
| Landeau, B | 1 |
| Ray Chaudhuri, K | 1 |
| Brooks, DJ | 3 |
| Edison, P | 2 |
| Femminella, GD | 1 |
| Ninan, S | 1 |
| Atkinson, R | 1 |
| Bartels, AL | 1 |
| Willemsen, AT | 1 |
| Doorduin, J | 1 |
| de Vries, EF | 1 |
| Dierckx, RA | 1 |
| Leenders, KL | 1 |
| Ouchi, Y | 1 |
| Yagi, S | 1 |
| Yokokura, M | 1 |
| Sakamoto, M | 1 |
| Gerhard, A | 1 |
| Pavese, N | 1 |
| Hotton, G | 1 |
| Turkheimer, F | 1 |
| Es, M | 1 |
| Hammers, A | 1 |
| Eggert, K | 1 |
| Oertel, W | 1 |
| Banati, RB | 2 |
| Takaya, S | 1 |
| Hashikawa, K | 1 |
| Turkheimer, FE | 1 |
| Mottram, N | 1 |
| Deprez, M | 1 |
| Ishizu, K | 1 |
| Kawashima, H | 1 |
| Akiyama, H | 1 |
| Fukuyama, H | 1 |
| Roncaroli, F | 1 |
| Cicchetti, F | 1 |
| Brownell, AL | 1 |
| Williams, K | 1 |
| Chen, YI | 1 |
| Livni, E | 1 |
| Isacson, O | 1 |
| Bonuccelli, U | 1 |
| Nuti, A | 1 |
| Del Dotto, P | 1 |
| Piccini, P | 1 |
| Martini, C | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Muratorio, A | 1 |
1 review available for pk 11195 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Neuroinflammation in the living brain of Parkinson's disease.
Topics: Aged; Brain; Cocaine; Cytokines; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Humans; | 2009 |
1 trial available for pk 11195 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
[11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
Topics: Aged; Antiparkinson Agents; Brain; Brain Mapping; Case-Control Studies; Celecoxib; Cluster Analysis; | 2010 |
7 other studies available for pk 11195 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.
Topics: Adult; Aged; Brain; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; Parkinson Disease; | 2018 |
Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia.
Topics: Alzheimer Disease; Amyloid; Brain; Brain Mapping; Carbon Radioisotopes; Cognitive Dysfunction; Fluor | 2015 |
Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antineoplastic Agents; Brain Mapping; Cognition; Female; | 2016 |
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
Topics: Aged; Benzodiazepines; Brain; Carbon Radioisotopes; Diagnostic Imaging; Female; Humans; Isoquinoline | 2006 |
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu | 2007 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |
Platelet peripheral benzodiazepine receptors are decreased in Parkinson's disease.
Topics: Aged; Analysis of Variance; Binding Sites; Blood Platelets; Female; Humans; Isoquinolines; Kinetics; | 1991 |