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pk 11195 and Idiopathic Parkinson Disease

pk 11195 has been researched along with Idiopathic Parkinson Disease in 9 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
"10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1-methyl-propyl]-3-isoquinoline carboxamide), [11C]PIB (11C-Pittsburgh compound B), [18F]FDG-PET (18F-2-fluoro-2-deoxyglucose positron emission tomography) scans."1.42Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia. ( Ahmed, I; Aman, Y; Brooks, DJ; Chetelat, G; Edison, P; Fan, Z; Landeau, B; Ray Chaudhuri, K, 2015)
"We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue."1.34The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007)
"Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with akinesia, tremor and rigidity."1.33In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. ( Banati, RB; Brooks, DJ; Eggert, K; Es, M; Gerhard, A; Hammers, A; Hotton, G; Oertel, W; Pavese, N; Turkheimer, F, 2006)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kang, Y1
Mozley, PD1
Verma, A1
Schlyer, D1
Henchcliffe, C1
Gauthier, SA1
Chiao, PC1
He, B1
Nikolopoulou, A1
Logan, J1
Sullivan, JM1
Pryor, KO1
Hesterman, J1
Kothari, PJ1
Vallabhajosula, S1
Fan, Z2
Aman, Y1
Ahmed, I1
Chetelat, G1
Landeau, B1
Ray Chaudhuri, K1
Brooks, DJ3
Edison, P2
Femminella, GD1
Ninan, S1
Atkinson, R1
Bartels, AL1
Willemsen, AT1
Doorduin, J1
de Vries, EF1
Dierckx, RA1
Leenders, KL1
Ouchi, Y1
Yagi, S1
Yokokura, M1
Sakamoto, M1
Gerhard, A1
Pavese, N1
Hotton, G1
Turkheimer, F1
Es, M1
Hammers, A1
Eggert, K1
Oertel, W1
Banati, RB2
Takaya, S1
Hashikawa, K1
Turkheimer, FE1
Mottram, N1
Deprez, M1
Ishizu, K1
Kawashima, H1
Akiyama, H1
Fukuyama, H1
Roncaroli, F1
Cicchetti, F1
Brownell, AL1
Williams, K1
Chen, YI1
Livni, E1
Isacson, O1
Bonuccelli, U1
Nuti, A1
Del Dotto, P1
Piccini, P1
Martini, C1
Giannaccini, G1
Lucacchini, A1
Muratorio, A1

Reviews

1 review available for pk 11195 and Idiopathic Parkinson Disease

ArticleYear
Neuroinflammation in the living brain of Parkinson's disease.
    Parkinsonism & related disorders, 2009, Volume: 15 Suppl 3

    Topics: Aged; Brain; Cocaine; Cytokines; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Humans;

2009

Trials

1 trial available for pk 11195 and Idiopathic Parkinson Disease

ArticleYear
[11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
    Parkinsonism & related disorders, 2010, Volume: 16, Issue:1

    Topics: Aged; Antiparkinson Agents; Brain; Brain Mapping; Case-Control Studies; Celecoxib; Cluster Analysis;

2010

Other Studies

7 other studies available for pk 11195 and Idiopathic Parkinson Disease

ArticleYear
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018, Volume: 28, Issue:5

    Topics: Adult; Aged; Brain; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; Parkinson Disease;

2018
Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015, Volume: 11, Issue:6

    Topics: Alzheimer Disease; Amyloid; Brain; Brain Mapping; Carbon Radioisotopes; Cognitive Dysfunction; Fluor

2015
Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
    Journal of Alzheimer's disease : JAD, 2016, Volume: 51, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antineoplastic Agents; Brain Mapping; Cognition; Female;

2016
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
    Neurobiology of disease, 2006, Volume: 21, Issue:2

    Topics: Aged; Benzodiazepines; Brain; Carbon Radioisotopes; Diagnostic Imaging; Female; Humans; Isoquinoline

2006
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
    Journal of neuro-oncology, 2007, Volume: 85, Issue:1

    Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu

2007
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
    The European journal of neuroscience, 2002, Volume: 15, Issue:6

    Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins;

2002
Platelet peripheral benzodiazepine receptors are decreased in Parkinson's disease.
    Life sciences, 1991, Volume: 48, Issue:12

    Topics: Aged; Analysis of Variance; Binding Sites; Blood Platelets; Female; Humans; Isoquinolines; Kinetics;

1991