pk 11195 has been researched along with Huntington Disease in 10 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied 9 symptomatic Huntington's disease patients (age = 46." | 1.35 | Hypothalamic involvement in Huntington's disease: an in vivo PET study. ( Barker, RA; Pavese, N; Piccini, P; Politis, M; Tabrizi, SJ; Tai, YF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grecchi, E | 1 |
| Doyle, OM | 1 |
| Bertoldo, A | 2 |
| Pavese, N | 7 |
| Turkheimer, FE | 4 |
| Politis, M | 1 |
| Tai, YF | 6 |
| Tabrizi, SJ | 3 |
| Barker, RA | 3 |
| Piccini, P | 3 |
| Tomasi, G | 1 |
| Cobelli, C | 1 |
| Hammers, A | 3 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Edison, P | 2 |
| Roncaroli, F | 1 |
| Anderson, AN | 2 |
| Gerhard, A | 4 |
| Hinz, R | 1 |
| Brooks, DJ | 4 |
| Levivier, M | 1 |
| Przedborski, S | 1 |
| Gouhier, C | 1 |
| Chalon, S | 1 |
| Venier-Julienne, MC | 1 |
| Bodard, S | 1 |
| Benoit, J | 1 |
| Besnard, J | 1 |
| Guilloteau, D | 1 |
1 review available for pk 11195 and Huntington Disease
| Article | Year |
|---|---|
Imaging microglial activation in Huntington's disease.
Topics: Animals; Brain; Carbon Radioisotopes; Humans; Huntington Disease; Isoquinolines; Microglia; Positron | 2007 |
9 other studies available for pk 11195 and Huntington Disease
| Article | Year |
|---|---|
Brain shaving: adaptive detection for brain PET data.
Topics: Brain; Carbon Radioisotopes; Case-Control Studies; Humans; Huntington Disease; Image Processing, Com | 2014 |
Hypothalamic involvement in Huntington's disease: an in vivo PET study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Female; Heterozygote; Humans; Huntington Disease; Hypoth | 2008 |
Global-two-stage filtering of clinical PET parametric maps: application to [(11)C]-(R)-PK11195.
Topics: Adult; Algorithms; Arterioles; Bayes Theorem; Brain; Brain Mapping; Cerebral Arteries; Cerebral Vein | 2011 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
Reference and target region modeling of [11C]-(R)-PK11195 brain studies.
Topics: Algorithms; Antineoplastic Agents; Brain; Carbon Radioisotopes; Case-Control Studies; Cluster Analys | 2007 |
A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195.
Topics: Alzheimer Disease; Brain; Brain Mapping; Carbon Radioisotopes; Cluster Analysis; Computer Graphics; | 2007 |
Microglial activation in presymptomatic Huntington's disease gene carriers.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Corpus Striatum; Disease Progression; F | 2007 |
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Cholinergic Agents; Corpus Striatum; D | 1998 |
Neuroprotection of nerve growth factor-loaded microspheres on the D2 dopaminergic receptor positive-striatal neurones in quinolinic acid-lesioned rats: a quantitative autoradiographic assessment with iodobenzamide.
Topics: Animals; Antineoplastic Agents; Autoradiography; Benzamides; Biocompatible Materials; Corpus Striatu | 2000 |