pk 11195 has been researched along with Hepatic Encephalopathy in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear." | 2.52 | PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agusti, A | 1 |
| Dziedzic, JL | 1 |
| Hernandez-Rabaza, V | 1 |
| Guilarte, TR | 1 |
| Felipo, V | 1 |
| Su, YY | 1 |
| Yang, GF | 1 |
| Lu, GM | 1 |
| Wu, S | 1 |
| Zhang, LJ | 1 |
| Iversen, P | 1 |
| Hansen, DA | 1 |
| Bender, D | 1 |
| Rodell, A | 1 |
| Munk, OL | 1 |
| Cumming, P | 1 |
| Keiding, S | 1 |
| Ahboucha, S | 1 |
| Butterworth, RF | 4 |
| Norenberg, MD | 1 |
| Bender, AS | 1 |
| Leong, DK | 1 |
| Therrien, G | 1 |
| Swain, MS | 1 |
| Perney, P | 1 |
| Mousseau, DD | 1 |
| Lavoie, J | 2 |
| Fabbro-Peray, P | 1 |
| Blanc, F | 1 |
| Layrargues, GP | 2 |
| Ferrero, P | 1 |
| Rocca, P | 1 |
| Gualerzi, A | 1 |
| Benna, P | 1 |
| Enrichens, F | 1 |
| Olivero, G | 1 |
| Mao, P | 1 |
| Ravizza, L | 1 |
| Bergamasco, B | 1 |
2 reviews available for pk 11195 and Hepatic Encephalopathy
| Article | Year |
|---|---|
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea | 2015 |
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Mangan | 2007 |
7 other studies available for pk 11195 and Hepatic Encephalopathy
| Article | Year |
|---|---|
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.
Topics: Animals; Biomarkers; Brain; Carrier Proteins; Disease Models, Animal; Hepatic Encephalopathy; Imidaz | 2014 |
Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathy.
Topics: Adult; Brain; Carbon Radioisotopes; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; | 2006 |
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor | 1994 |
Densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand 3H-PK11195 are increased in brain 24 hours following portacaval anastomosis.
Topics: Animals; Binding Sites; Brain; Hepatic Encephalopathy; Isoquinolines; Male; Portacaval Shunt, Surgic | 1994 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo | 1998 |
A study of 3H-PK 11,195 binding to "peripheral-type" benzodiazepine receptors on human lymphocytes. Evidence of decreased binding in hepatic encephalopathy.
Topics: Adult; Aged; Biomarkers; Female; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Lym | 1991 |
Increased densities of peripheral-type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy.
Topics: Binding Sites; Binding, Competitive; Brain; Fibrosis; Hepatic Encephalopathy; Humans; Isoquinolines; | 1990 |