Page last updated: 2024-10-21

pk 11195 and Hepatic Encephalopathy

pk 11195 has been researched along with Hepatic Encephalopathy in 9 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear."2.52PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's2 (22.22)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agusti, A1
Dziedzic, JL1
Hernandez-Rabaza, V1
Guilarte, TR1
Felipo, V1
Su, YY1
Yang, GF1
Lu, GM1
Wu, S1
Zhang, LJ1
Iversen, P1
Hansen, DA1
Bender, D1
Rodell, A1
Munk, OL1
Cumming, P1
Keiding, S1
Ahboucha, S1
Butterworth, RF4
Norenberg, MD1
Bender, AS1
Leong, DK1
Therrien, G1
Swain, MS1
Perney, P1
Mousseau, DD1
Lavoie, J2
Fabbro-Peray, P1
Blanc, F1
Layrargues, GP2
Ferrero, P1
Rocca, P1
Gualerzi, A1
Benna, P1
Enrichens, F1
Olivero, G1
Mao, P1
Ravizza, L1
Bergamasco, B1

Reviews

2 reviews available for pk 11195 and Hepatic Encephalopathy

ArticleYear
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
    Metabolic brain disease, 2015, Volume: 30, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea

2015
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Mangan

2007

Other Studies

7 other studies available for pk 11195 and Hepatic Encephalopathy

ArticleYear
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Animals; Biomarkers; Brain; Carrier Proteins; Disease Models, Animal; Hepatic Encephalopathy; Imidaz

2014
Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathy.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:7

    Topics: Adult; Brain; Carbon Radioisotopes; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis;

2006
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor

1994
Densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand 3H-PK11195 are increased in brain 24 hours following portacaval anastomosis.
    Metabolic brain disease, 1994, Volume: 9, Issue:3

    Topics: Animals; Binding Sites; Brain; Hepatic Encephalopathy; Isoquinolines; Male; Portacaval Shunt, Surgic

1994
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
    Metabolic brain disease, 1998, Volume: 13, Issue:3

    Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo

1998
A study of 3H-PK 11,195 binding to "peripheral-type" benzodiazepine receptors on human lymphocytes. Evidence of decreased binding in hepatic encephalopathy.
    Journal of the neurological sciences, 1991, Volume: 102, Issue:2

    Topics: Adult; Aged; Biomarkers; Female; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Lym

1991
Increased densities of peripheral-type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:5

    Topics: Binding Sites; Binding, Competitive; Brain; Fibrosis; Hepatic Encephalopathy; Humans; Isoquinolines;

1990