Page last updated: 2024-10-21

pk 11195 and HIV

pk 11195 has been researched along with HIV in 3 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garvey, LJ1
Pavese, N1
Ramlackhansingh, A1
Thomson, E1
Allsop, JM1
Politis, M1
Kulasegaram, R1
Main, J1
Brooks, DJ1
Taylor-Robinson, SD1
Winston, A1
Wiley, CA2
Lopresti, BJ1
Becker, JT1
Boada, F1
Lopez, OL1
Mellors, J1
Meltzer, CC1
Wisniewski, SR1
Mathis, CA1
Venneti, S1
Wang, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Case-control Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-infection - a PET Study[NCT00959166]81 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Association of 11C-labelled PK11195 Uptake Using PET With Acute HCV and HIV Infection

Association of 11C-labelled PK11195 uptake using PET with acute HCV and HIV infection by PK11195 PET ligand binding. The ligand PK11195 is selective for the peripheral benzodiazepine binding site and exhibits minimal binding in normal brain. In brain lesions, however, there is a massive increase in binding. (NCT00959166)
Timeframe: 30 days

Interventionbinding potential ratio (Mean)
HIV/Acute HCV Coinfection0.18
HIV Mono0.22

Ratio of NAA/Cr (N-acetyl Aspartate/Creatine) Cerebral Metabolites

"Association between patient characteristics and 11C-labelled PK11195 uptake using PET, CNS metabolite ratios.~By quantifying the surrogate markers of N-acetylaspartate (NAA), creatine (Cr) offers insight into the neuronal integrity, cell membrane synthesis and turnover, macrophage infiltration, inflammation status, and levels of microglial activation and gliosis within the sampled CNS tissue." (NCT00959166)
Timeframe: 30 days

Interventionratio (Mean)
HIV/Acute HCV Coinfection1.42
HIV Mono1.35

Other Studies

3 other studies available for pk 11195 and HIV

ArticleYear
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Acute Disease; Adult; Biological Transport; Carbon Radioisotopes; Case-Control Studies; Cerebral Cor

2012
Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.
    Journal of neurovirology, 2006, Volume: 12, Issue:4

    Topics: Adult; Aged; AIDS Dementia Complex; Brain; Carbon Radioisotopes; HIV; HIV Infections; Humans; Isoqui

2006
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
    Neuroscience letters, 2007, Oct-16, Volume: 426, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie

2007