pk 11195 and HIV
pk 11195 has been researched along with HIV in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Garvey, LJ | 1 |
| Pavese, N | 1 |
| Ramlackhansingh, A | 1 |
| Thomson, E | 1 |
| Allsop, JM | 1 |
| Politis, M | 1 |
| Kulasegaram, R | 1 |
| Main, J | 1 |
| Brooks, DJ | 1 |
| Taylor-Robinson, SD | 1 |
| Winston, A | 1 |
| Wiley, CA | 2 |
| Lopresti, BJ | 1 |
| Becker, JT | 1 |
| Boada, F | 1 |
| Lopez, OL | 1 |
| Mellors, J | 1 |
| Meltzer, CC | 1 |
| Wisniewski, SR | 1 |
| Mathis, CA | 1 |
| Venneti, S | 1 |
| Wang, G | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Case-control Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-infection - a PET Study[NCT00959166] | 81 participants (Actual) | Interventional | 2009-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Association of 11C-labelled PK11195 Uptake Using PET With Acute HCV and HIV Infection
Association of 11C-labelled PK11195 uptake using PET with acute HCV and HIV infection by PK11195 PET ligand binding. The ligand PK11195 is selective for the peripheral benzodiazepine binding site and exhibits minimal binding in normal brain. In brain lesions, however, there is a massive increase in binding. (NCT00959166)
Timeframe: 30 days
| Intervention | binding potential ratio (Mean) |
|---|---|
| HIV/Acute HCV Coinfection | 0.18 |
| HIV Mono | 0.22 |
Ratio of NAA/Cr (N-acetyl Aspartate/Creatine) Cerebral Metabolites
"Association between patient characteristics and 11C-labelled PK11195 uptake using PET, CNS metabolite ratios.~By quantifying the surrogate markers of N-acetylaspartate (NAA), creatine (Cr) offers insight into the neuronal integrity, cell membrane synthesis and turnover, macrophage infiltration, inflammation status, and levels of microglial activation and gliosis within the sampled CNS tissue." (NCT00959166)
Timeframe: 30 days
| Intervention | ratio (Mean) |
|---|---|
| HIV/Acute HCV Coinfection | 1.42 |
| HIV Mono | 1.35 |
Other Studies
3 other studies available for pk 11195 and HIV
| Article | Year |
|---|---|
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
Topics: Acute Disease; Adult; Biological Transport; Carbon Radioisotopes; Case-Control Studies; Cerebral Cor | 2012 |
Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.
Topics: Adult; Aged; AIDS Dementia Complex; Brain; Carbon Radioisotopes; HIV; HIV Infections; Humans; Isoqui | 2006 |
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie | 2007 |