pk 11195 has been researched along with HIV Infections in 2 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garvey, LJ | 1 |
| Pavese, N | 1 |
| Ramlackhansingh, A | 1 |
| Thomson, E | 1 |
| Allsop, JM | 1 |
| Politis, M | 1 |
| Kulasegaram, R | 1 |
| Main, J | 1 |
| Brooks, DJ | 1 |
| Taylor-Robinson, SD | 1 |
| Winston, A | 1 |
| Wiley, CA | 1 |
| Lopresti, BJ | 1 |
| Becker, JT | 1 |
| Boada, F | 1 |
| Lopez, OL | 1 |
| Mellors, J | 1 |
| Meltzer, CC | 1 |
| Wisniewski, SR | 1 |
| Mathis, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Case-control Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-infection - a PET Study[NCT00959166] | 81 participants (Actual) | Interventional | 2009-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Association of 11C-labelled PK11195 uptake using PET with acute HCV and HIV infection by PK11195 PET ligand binding. The ligand PK11195 is selective for the peripheral benzodiazepine binding site and exhibits minimal binding in normal brain. In brain lesions, however, there is a massive increase in binding. (NCT00959166)
Timeframe: 30 days
| Intervention | binding potential ratio (Mean) |
|---|---|
| HIV/Acute HCV Coinfection | 0.18 |
| HIV Mono | 0.22 |
"Association between patient characteristics and 11C-labelled PK11195 uptake using PET, CNS metabolite ratios.~By quantifying the surrogate markers of N-acetylaspartate (NAA), creatine (Cr) offers insight into the neuronal integrity, cell membrane synthesis and turnover, macrophage infiltration, inflammation status, and levels of microglial activation and gliosis within the sampled CNS tissue." (NCT00959166)
Timeframe: 30 days
| Intervention | ratio (Mean) |
|---|---|
| HIV/Acute HCV Coinfection | 1.42 |
| HIV Mono | 1.35 |
2 other studies available for pk 11195 and HIV Infections
| Article | Year |
|---|---|
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
Topics: Acute Disease; Adult; Biological Transport; Carbon Radioisotopes; Case-Control Studies; Cerebral Cor | 2012 |
Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.
Topics: Adult; Aged; AIDS Dementia Complex; Brain; Carbon Radioisotopes; HIV; HIV Infections; Humans; Isoqui | 2006 |