pk 11195 has been researched along with Glioma in 27 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present work, we investigated the ability of the specific PBR ligands, PK 11195 or Ro5-4864, to affect mitochondrial potential and to induce apoptotic cell death in rat C6 glioma cells." | 3.72 | Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. ( Abbracchio, MP; Ceruti, S; Chelli, B; Costa, B; Da Pozzo, E; Gremigni, V; Lena, A; Martini, C; Rossi, L; Salvetti, A; Scatena, F; Vanacore, R, 2004) |
| " To elucidate the biological role of the PBD receptor on mitochondria, we examined the effect of PBDs on mitochondrial morphology in C6 and T98G glioma cells using rhodamine 123 and quantitative electron microscopy." | 3.68 | Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells. ( Becker, DP; Black, KL; Ikezaki, K; Shiraishi, T, 1991) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| " In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with intracranial C6 gliomas resulted in high levels of tritiated-drug binding to the tumor as shown by quantitative autoradiography." | 3.67 | Imaging of a glioma using peripheral benzodiazepine receptor ligands. ( Ciliax, BJ; McKeever, P; Penney, JB; Starosta-Rubinstein, S; Young, AB, 1987) |
| "Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues." | 3.67 | Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988) |
| "TSPO in gliomas was expressed predominantly by neoplastic cells, and its expression correlated positively with BPND in the tumors." | 1.42 | The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study. ( Brodbelt, A; Coope, DJ; Du Plessis, D; Durrenberger, PF; Gerhard, A; Herholz, K; Hinz, R; Jackson, A; Janczar, K; Karabatsou, K; Roncaroli, F; Su, Z; Thompson, G; Turkheimer, FE, 2015) |
| "Gliomas are one of the most malignant cancers." | 1.35 | TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells. ( Chelli, B; Costa, B; Da Pozzo, E; Evangelista, M; Gremigni, V; Lena, A; Martini, C; Rainaldi, G; Rechichi, M; Rossi, L; Salvetti, A; Spinetti, F, 2008) |
| " These studies consisted of single-dose and steady-state dosing regimen studies, the latter to assess drug distribution in normal brain and brain tumors." | 1.31 | Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. ( Adams, AL; Gallo, JM; Guo, P; Guo, Z; Li, S; Ma, J, 2001) |
| "C6 glioma has a KD significantly greater than rat cortex." | 1.28 | Autoradiographic study of peripheral benzodiazepine receptors in animal brain tumor models and human gliomas. ( Diksic, M; Mitsuka, S; Takada, A; Yamamoto, YL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.93) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Mohler, ML | 1 |
| Kang, GS | 1 |
| Hong, SS | 1 |
| Patil, R | 1 |
| Kirichenko, OV | 1 |
| Li, W | 1 |
| Rakov, IM | 1 |
| Geisert, EE | 1 |
| Miller, DD | 1 |
| Gao, ZW | 1 |
| Huang, YY | 1 |
| Zhang, JQ | 1 |
| Rong, JY | 1 |
| Qiao, GY | 1 |
| Chen, N | 1 |
| Yu, GD | 1 |
| Luo, M | 1 |
| Liu, XF | 1 |
| Su, Z | 1 |
| Roncaroli, F | 1 |
| Durrenberger, PF | 1 |
| Coope, DJ | 1 |
| Karabatsou, K | 1 |
| Hinz, R | 1 |
| Thompson, G | 1 |
| Turkheimer, FE | 1 |
| Janczar, K | 1 |
| Du Plessis, D | 1 |
| Brodbelt, A | 1 |
| Jackson, A | 1 |
| Gerhard, A | 1 |
| Herholz, K | 1 |
| Costa, B | 4 |
| Da Pozzo, E | 3 |
| Cavallini, C | 1 |
| Taliani, S | 1 |
| Da Settimo, F | 1 |
| Martini, C | 4 |
| Buck, JR | 1 |
| McKinley, ET | 1 |
| Hight, MR | 1 |
| Fu, A | 1 |
| Tang, D | 1 |
| Smith, RA | 1 |
| Tantawy, MN | 1 |
| Peterson, TE | 1 |
| Colvin, D | 1 |
| Ansari, MS | 1 |
| Baldwin, RM | 1 |
| Zhao, P | 1 |
| Guleryuz, S | 1 |
| Manning, HC | 1 |
| Crossley, EL | 1 |
| Issa, F | 1 |
| Scarf, AM | 1 |
| Kassiou, M | 1 |
| Rendina, LM | 1 |
| Chelli, B | 2 |
| Lena, A | 2 |
| Vanacore, R | 1 |
| Rossi, L | 2 |
| Salvetti, A | 2 |
| Scatena, F | 1 |
| Ceruti, S | 1 |
| Abbracchio, MP | 1 |
| Gremigni, V | 2 |
| Rechichi, M | 1 |
| Spinetti, F | 1 |
| Evangelista, M | 1 |
| Rainaldi, G | 1 |
| Ikezaki, K | 5 |
| Nomura, T | 1 |
| Takahashi, M | 1 |
| Fritz-Zieroth, B | 1 |
| Inamura, T | 1 |
| Fukui, M | 1 |
| Miyazawa, N | 1 |
| Hamel, E | 1 |
| Diksic, M | 2 |
| Miccoli, L | 1 |
| Oudard, S | 1 |
| Beurdeley-Thomas, A | 1 |
| Dutrillaux, B | 1 |
| Poupon, MF | 1 |
| Selleri, S | 1 |
| Bruni, F | 1 |
| Costagli, C | 1 |
| Costanzo, A | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Guo, P | 1 |
| Ma, J | 1 |
| Li, S | 1 |
| Guo, Z | 1 |
| Adams, AL | 1 |
| Gallo, JM | 1 |
| Olson, JM | 3 |
| McNeel, W | 1 |
| Young, AB | 5 |
| Mancini, WR | 2 |
| Takada, A | 1 |
| Mitsuka, S | 1 |
| Yamamoto, YL | 1 |
| Cornu, P | 1 |
| Benavides, J | 1 |
| Scatton, B | 1 |
| Hauw, JJ | 1 |
| Philippon, J | 1 |
| Shiraishi, T | 1 |
| Black, KL | 4 |
| Becker, DP | 2 |
| Santori, EM | 1 |
| Smith, ML | 1 |
| Payne, BA | 1 |
| Toga, AW | 2 |
| Broaddus, WC | 1 |
| Bennett, JP | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
| Gildersleeve, DL | 2 |
| Lin, TY | 1 |
| Wieland, DM | 2 |
| Ciliax, BJ | 3 |
| Ferrarese, C | 1 |
| Appollonio, I | 1 |
| Frigo, M | 1 |
| Gaini, SM | 1 |
| Piolti, R | 1 |
| Frattola, L | 1 |
| Van Dort, ME | 1 |
| Sherman, PS | 1 |
| Rosenspire, KC | 1 |
| Junck, L | 2 |
| Starosta-Rubinstein, S | 1 |
| Penney, JB | 2 |
| McKeever, P | 1 |
27 other studies available for pk 11195 and Glioma
| Article | Year |
|---|---|
Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.
Topics: Animals; Antineoplastic Agents; Astrocytes; Biphenyl Compounds; Cell Line, Tumor; Cells, Cultured; D | 2006 |
Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Disease Models, An | 2021 |
The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Biomarkers, Tumor; Blood-Brain Barrier; Brain; Brain Neop | 2015 |
Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.
Topics: Adrenal Glands; Animals; Anti-Anxiety Agents; Antineoplastic Agents; Carrier Proteins; Cell Line, Tu | 2016 |
Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline.
Topics: Acetanilides; Animals; Carrier Proteins; Cell Line, Tumor; Fluorine Radioisotopes; Glioma; Isoquinol | 2011 |
Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells.
Topics: Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, T | 2011 |
Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Caspase 3; Caspases; GABA-A Receptor A | 2004 |
TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Movement; Cell Proliferation; Drug Resistance | 2008 |
Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors.
Topics: Animals; Brain Neoplasms; Clonazepam; Contrast Media; Glioma; Isoquinolines; Kidney; Magnetic Resona | 1994 |
Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain Neoplasms; Cell Differentiation; Glioma; Huma | 1998 |
Effect of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide (PK11195), a specific ligand of the peripheral benzodiazepine receptor, on the lipid fluidity of mitochondria in human glioma cells.
Topics: Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; GABA-A Receptor Agonists; Glioma; Humans; Isoquino | 1999 |
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glio | 2001 |
Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Deoxycytidine; Drug Delivery Systems; Gem | 2001 |
Localization of the peripheral-type benzodiazepine binding site to mitochondria of human glioma cells.
Topics: Alkaline Phosphatase; Animals; Cell Line; DNA, Neoplasm; Glioma; Humans; Isoquinolines; Mitochondria | 1992 |
Autoradiographic study of peripheral benzodiazepine receptors in animal brain tumor models and human gliomas.
Topics: Animals; Autoradiography; Brain; Brain Neoplasms; Glioma; Humans; Isoquinolines; Kinetics; Rats; Rat | 1992 |
Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain; Brain Neoplasms; Cerebellar Neoplasms; Gliom | 1992 |
Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells.
Topics: Animals; Benzodiazepinones; Cell Line; Clonazepam; Culture Media, Serum-Free; Fluorescent Dyes; Glio | 1991 |
Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Line; DNA Replication; DNA, Neoplas | 1990 |
Three-dimensional comparison of peripheral benzodiazepine binding and histological findings in rat brain tumor.
Topics: Animals; Brain Neoplasms; Female; Flunitrazepam; Glioma; Isoquinolines; Rats; Rats, Inbred Strains; | 1990 |
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma; | 1990 |
Imaging of brain tumors using peripheral benzodiazepine receptor ligands.
Topics: Animals; Autoradiography; Brain Neoplasms; Clonazepam; Female; Flunitrazepam; Glioma; Image Processi | 1989 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |
Synthesis of a high specific activity 125I-labeled analog of PK 11195, potential agent for SPECT imaging of the peripheral benzodiazepine binding site.
Topics: Animals; Brain Neoplasms; Chromatography, High Pressure Liquid; Glioma; Humans; In Vitro Techniques; | 1989 |
Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Diazepam Binding Inhibitor; Female; Fl | 1989 |
Radioiodinated benzodiazepines: agents for mapping glial tumors.
Topics: Animals; Autoradiography; Benzodiazepinones; Binding, Competitive; Glioma; Iodine Radioisotopes; Iso | 1988 |
Imaging of a glioma using peripheral benzodiazepine receptor ligands.
Topics: Adrenal Gland Neoplasms; Animals; Flunitrazepam; Glioma; Humans; Isoquinolines; Kidney; Mice; Mice, | 1987 |
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans; | 1988 |